Effect of topical 0.05% cyclosporine A on corneal endothelium in patients with dry eye disease
<b>AIM:</b>To determine the effect of topical 0.05% cyclosporine A (CsA) on corneal endothelium in patients with dry eye disease.<b>METHODS:</b> Observational, prospective, case series study. Fifty-five eyes of 29 consecutive patients (9 males and 20 females; median age:66.8...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2013-08-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2013/4/20130412.pdf |
| Summary: | <b>AIM:</b>To determine the effect of topical 0.05% cyclosporine A (CsA) on corneal endothelium in patients with dry eye disease.<b>METHODS:</b> Observational, prospective, case series study. Fifty-five eyes of 29 consecutive patients (9 males and 20 females; median age:66.8 years, interquartile range:61-73.2 years) with moderate-severe dry eye disease were evaluated. All patients were treated with topical 0.05% CsA ophthalmic emulsion twice a day in addition to lubricant eyedrops 5 times a day. The follow-up period was 12 months. Before treatment and at 3 and 12 months post-treatment central corneal specular microscopy was performed. The endothelial cell density (ECD), coefficient of variation of cell size (CoV), and percentage of hexagonal cells (Hex %) were analyzed.<b>RESULTS:</b> The median ECDs pre-treatment and at 3 and 12 months post-treatment were 2 352.5/mm<sup>2</sup> (interquartile range, 2 178-2 548.5), 2364/mm<sup>2</sup> (interquartile range, 2 174.25-2 657.5), and 2366 cells/mm<sup>2</sup> (interquartile range, 2 174.75-2 539.75), respectively (<i>P</i>=0.927, one way ANOVA). The median CoVs pre-treatment and at 3 and 12 months post-treatment were 34.5 (interquartile range, 30-37), 35 (interquartile range, 30-38), and 34 (interquartile range, 30.75-38.25), respectively (<i>P</i>=0.7193, one way ANOVA). The median Hex % values pre-treatment and at 3 and 12 months post-treatment were 53 (interquartile range, 47-58), 54 (interquartile range, 45.75-59), and 50.5 (interquartile range, 45.75-58), respectively (<i>P</i>=0.824, one way ANOVA).<b>CONCLUSION:</b> Treatment of patients with dry eye disease for 12 months with topical 0.05% CsA does not seem to cause substantial changes on corneal endothelium. |
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| ISSN: | 2222-3959 2227-4898 |