Anti-inflammation performance of curcumin-loaded mesoporous calcium silicate cement
Calcium silicate (CS) cements have excellent bioactivity and can induce the bone-like apatite formation. They are good biomaterials for bone tissue engineering and bone regenerative medicine. However, they have degradability and the dissolved CS can cause the inflammatory response at the early post-...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-09-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664617302395 |
| _version_ | 1828426156923158528 |
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| author | Yuan-Chien Chen Ming-You Shie Yuan-Haw Andrew Wu Kai-Xing Alvin Lee Li-Ju Wei Yu-Fang Shen |
| author_facet | Yuan-Chien Chen Ming-You Shie Yuan-Haw Andrew Wu Kai-Xing Alvin Lee Li-Ju Wei Yu-Fang Shen |
| author_sort | Yuan-Chien Chen |
| collection | DOAJ |
| description | Calcium silicate (CS) cements have excellent bioactivity and can induce the bone-like apatite formation. They are good biomaterials for bone tissue engineering and bone regenerative medicine. However, they have degradability and the dissolved CS can cause the inflammatory response at the early post-implantation stage. The purpose of this study was to design and prepare the curcumin-loaded mesoporous CS (MesoCS/curcumin) cements as a strategy to reduce the inflammatory reaction after implantation.
Methods: The MesoCS/curcumin cements were designed and prepared. The characteristics of MesoCS/curcumin specimens were examined by transmission electron microscopy (TEM), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Their physical properties, biocompatibility, and anti-inflammatory ability were also evaluated.
Results: The MesoCS/curcumin cements displayed excellent biocompatibility and physical properties. Their crystalline characterizations were very similar with MesoCS cements. After soaking in simulated body fluid, the bone-like apatite layer of the MesoCS/curcumin cements could be formed. In addition, it could inhibit the expression of tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) after inflammation reaction induced by lipopolysaccharides and had good anti-inflammatory ability.
Conclusion: Adding curcumin in MesoCS cements can reduce the inflammatory reaction, but does not affect the original biological activity and properties of MesoCS cements. It can provide a good strategy to inhibit the inflammatory reaction after implantation for bone tissue engineering and bone regenerative medicine. |
| first_indexed | 2024-12-10T16:40:45Z |
| format | Article |
| id | doaj.art-eeccec3f0fac4bcbb907e19e76879f3b |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-10T16:40:45Z |
| publishDate | 2017-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-eeccec3f0fac4bcbb907e19e76879f3b2022-12-22T01:41:14ZengElsevierJournal of the Formosan Medical Association0929-66462017-09-01116967968810.1016/j.jfma.2017.06.005Anti-inflammation performance of curcumin-loaded mesoporous calcium silicate cementYuan-Chien Chen0Ming-You Shie1Yuan-Haw Andrew Wu2Kai-Xing Alvin Lee3Li-Ju Wei4Yu-Fang Shen5School of Dentistry, China Medical University, Taichung, TaiwanSchool of Dentistry, China Medical University, Taichung, Taiwan3D Printing Medical Research Center, China Medical University Hospital, Taichung, Taiwan3D Printing Medical Research Center, China Medical University Hospital, Taichung, Taiwan3D Printing Medical Research Center, China Medical University Hospital, Taichung, TaiwanDepartment of Bioinformatics and Medical Engineering, Asia University, Taichung, TaiwanCalcium silicate (CS) cements have excellent bioactivity and can induce the bone-like apatite formation. They are good biomaterials for bone tissue engineering and bone regenerative medicine. However, they have degradability and the dissolved CS can cause the inflammatory response at the early post-implantation stage. The purpose of this study was to design and prepare the curcumin-loaded mesoporous CS (MesoCS/curcumin) cements as a strategy to reduce the inflammatory reaction after implantation. Methods: The MesoCS/curcumin cements were designed and prepared. The characteristics of MesoCS/curcumin specimens were examined by transmission electron microscopy (TEM), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Their physical properties, biocompatibility, and anti-inflammatory ability were also evaluated. Results: The MesoCS/curcumin cements displayed excellent biocompatibility and physical properties. Their crystalline characterizations were very similar with MesoCS cements. After soaking in simulated body fluid, the bone-like apatite layer of the MesoCS/curcumin cements could be formed. In addition, it could inhibit the expression of tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) after inflammation reaction induced by lipopolysaccharides and had good anti-inflammatory ability. Conclusion: Adding curcumin in MesoCS cements can reduce the inflammatory reaction, but does not affect the original biological activity and properties of MesoCS cements. It can provide a good strategy to inhibit the inflammatory reaction after implantation for bone tissue engineering and bone regenerative medicine.http://www.sciencedirect.com/science/article/pii/S0929664617302395Anti-inflammationCurcuminMesoporousCalcium silicateBone cement |
| spellingShingle | Yuan-Chien Chen Ming-You Shie Yuan-Haw Andrew Wu Kai-Xing Alvin Lee Li-Ju Wei Yu-Fang Shen Anti-inflammation performance of curcumin-loaded mesoporous calcium silicate cement Journal of the Formosan Medical Association Anti-inflammation Curcumin Mesoporous Calcium silicate Bone cement |
| title | Anti-inflammation performance of curcumin-loaded mesoporous calcium silicate cement |
| title_full | Anti-inflammation performance of curcumin-loaded mesoporous calcium silicate cement |
| title_fullStr | Anti-inflammation performance of curcumin-loaded mesoporous calcium silicate cement |
| title_full_unstemmed | Anti-inflammation performance of curcumin-loaded mesoporous calcium silicate cement |
| title_short | Anti-inflammation performance of curcumin-loaded mesoporous calcium silicate cement |
| title_sort | anti inflammation performance of curcumin loaded mesoporous calcium silicate cement |
| topic | Anti-inflammation Curcumin Mesoporous Calcium silicate Bone cement |
| url | http://www.sciencedirect.com/science/article/pii/S0929664617302395 |
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