Testosterone deficiency impairs cardiac interfibrillar mitochondrial function and myocardial contractility while inducing oxidative stress

Testosterone deficiency impairs cardiac interfibrillar mitochondrial function and myocardial contractility while inducing oxidative stress

IntroductionClinical studies have shown that low levels of endogenous testosterone are associated with cardiovascular diseases. Considering the intimate connection between oxidative metabolism and myocardial contractility, we determined the effects of testosterone deficiency on the two spatially dis...

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Main Authors: Patrícia Ribeiro do Val Lima, Karoline Sousa Ronconi, Elis Aguiar Morra, Paula Lopes Rodrigues, Renata Andrade Ávila, Eduardo Merlo, Jones B. Graceli, Maylla Ronacher Simões, Ivanita Stefanon, Rogério Faustino Ribeiro Júnior
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Endocrinology
Subjects:
testosterone
mitochondria
cardiac contractility
subsarcolemmal
interfibrillar
mitochondrial subpopulations
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1206387/full

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