Virologic response to efavirenz-based first-line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission.
Efavirenz-based first-line regimens have been widely used for children ≥3 years of age starting antiretroviral therapy, despite possible resistance with prior exposure to non-nucleoside reverse transcriptase inhibitors for prevention of mother-to-child transmission (PMTCT). We used logistic regressi...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0233693 |
| _version_ | 1818919517634428928 |
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| author | Patience Nyakato Mary-Ann Davies Karl-Gunter Technau Geoffrey Fatti Helena Rabie Frank Tanser Andrew Boulle Robin Wood Brian Eley Shobna Sawry Janet Giddy Nosisa Sipambo Louise Kuhn Lee Fairlie International epidemiology Database to Evaluate AIDS-Southern Africa (IeDEA-SA) Collaboration |
| author_facet | Patience Nyakato Mary-Ann Davies Karl-Gunter Technau Geoffrey Fatti Helena Rabie Frank Tanser Andrew Boulle Robin Wood Brian Eley Shobna Sawry Janet Giddy Nosisa Sipambo Louise Kuhn Lee Fairlie International epidemiology Database to Evaluate AIDS-Southern Africa (IeDEA-SA) Collaboration |
| author_sort | Patience Nyakato |
| collection | DOAJ |
| description | Efavirenz-based first-line regimens have been widely used for children ≥3 years of age starting antiretroviral therapy, despite possible resistance with prior exposure to non-nucleoside reverse transcriptase inhibitors for prevention of mother-to-child transmission (PMTCT). We used logistic regression to examine the association between PMTCT exposure and viral failure (VF) defined as two consecutive viral loads (VL)>1000 copies/ml between 6-18 months on ART. Children with previous nevirapine exposure for PMTCT were not at higher risk of VF compared to unexposed children (adjusted Odds Ratio (aOR): 0.79; 95% CI:0.56, 1.11). |
| first_indexed | 2024-12-20T01:07:07Z |
| format | Article |
| id | doaj.art-eed2c839b7e74cf6b02e8a136db950dd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T01:07:07Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-eed2c839b7e74cf6b02e8a136db950dd2022-12-21T19:58:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01155e023369310.1371/journal.pone.0233693Virologic response to efavirenz-based first-line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission.Patience NyakatoMary-Ann DaviesKarl-Gunter TechnauGeoffrey FattiHelena RabieFrank TanserAndrew BoulleRobin WoodBrian EleyShobna SawryJanet GiddyNosisa SipamboLouise KuhnLee FairlieInternational epidemiology Database to Evaluate AIDS-Southern Africa (IeDEA-SA) CollaborationEfavirenz-based first-line regimens have been widely used for children ≥3 years of age starting antiretroviral therapy, despite possible resistance with prior exposure to non-nucleoside reverse transcriptase inhibitors for prevention of mother-to-child transmission (PMTCT). We used logistic regression to examine the association between PMTCT exposure and viral failure (VF) defined as two consecutive viral loads (VL)>1000 copies/ml between 6-18 months on ART. Children with previous nevirapine exposure for PMTCT were not at higher risk of VF compared to unexposed children (adjusted Odds Ratio (aOR): 0.79; 95% CI:0.56, 1.11).https://doi.org/10.1371/journal.pone.0233693 |
| spellingShingle | Patience Nyakato Mary-Ann Davies Karl-Gunter Technau Geoffrey Fatti Helena Rabie Frank Tanser Andrew Boulle Robin Wood Brian Eley Shobna Sawry Janet Giddy Nosisa Sipambo Louise Kuhn Lee Fairlie International epidemiology Database to Evaluate AIDS-Southern Africa (IeDEA-SA) Collaboration Virologic response to efavirenz-based first-line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission. PLoS ONE |
| title | Virologic response to efavirenz-based first-line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission. |
| title_full | Virologic response to efavirenz-based first-line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission. |
| title_fullStr | Virologic response to efavirenz-based first-line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission. |
| title_full_unstemmed | Virologic response to efavirenz-based first-line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission. |
| title_short | Virologic response to efavirenz-based first-line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission. |
| title_sort | virologic response to efavirenz based first line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother to child transmission |
| url | https://doi.org/10.1371/journal.pone.0233693 |
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