Clinical Impact of Nutritional Status and Sarcopenia in Pediatric Patients with Bone and Soft Tissue Sarcomas: A Pilot Retrospective Study (SarcoPed)
Background: We evaluated nutritional and sarcopenia status and their clinical impact in pediatric patients affected by bone and soft tissue sarcomas. Methods: Body mass index (BMI), prognostic nutritional index (PNI), and total psoas muscle area (tPMA) at diagnosis and after 12 months were analyzed....
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/2/383 |
| _version_ | 1797491376110174208 |
|---|---|
| author | Alberto Romano Silvia Triarico Emanuele Rinninella Luigi Natale Maria Gabriella Brizi Marco Cintoni Pauline Raoul Palma Maurizi Giorgio Attinà Stefano Mastrangelo Antonio Gasbarrini Maria Cristina Mele Antonio Ruggiero |
| author_facet | Alberto Romano Silvia Triarico Emanuele Rinninella Luigi Natale Maria Gabriella Brizi Marco Cintoni Pauline Raoul Palma Maurizi Giorgio Attinà Stefano Mastrangelo Antonio Gasbarrini Maria Cristina Mele Antonio Ruggiero |
| author_sort | Alberto Romano |
| collection | DOAJ |
| description | Background: We evaluated nutritional and sarcopenia status and their clinical impact in pediatric patients affected by bone and soft tissue sarcomas. Methods: Body mass index (BMI), prognostic nutritional index (PNI), and total psoas muscle area (tPMA) at diagnosis and after 12 months were analyzed. tPMA was measured from single cross-sectional computed tomography (CT) images at L4–L5. Age-specific and sex-specific tPMA Z-scores were retrieved from an online calculator. Results: A total of 21 patients were identified between February 2013 and December 2018. Twelve patients (57.1%) experienced sarcopenia at diagnosis, although not statistically associated with overall survival (OS) (<i>p</i> = 0.09). BMI Z-score, PNI, and tPMA Z-score significantly decreased between diagnosis and after 12 months of treatment (<i>p</i> < 0.05). Univariate analysis showed significant associations between poor OS and the presence of metastasis (<i>p</i> = 0.008), the absence of surgery (<i>p</i> = 0.005), PNI decrease (<i>p</i> = 0.027), and the reduction in tPMA > 25% (<i>p</i> = 0.042) over the 12 months. Conclusions: Sarcopenia affects more than half of the patients at diagnosis. Decreased PNI during 12 months of treatment has significant predictive value for OS. The role of tPMA derived from CT scan among pediatric patients with sarcoma should be investigated in further prospective and larger studies. |
| first_indexed | 2024-03-10T00:47:35Z |
| format | Article |
| id | doaj.art-eed4fe39ec064c558ee64ce343dbcdc4 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T00:47:35Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-eed4fe39ec064c558ee64ce343dbcdc42023-11-23T14:58:35ZengMDPI AGNutrients2072-66432022-01-0114238310.3390/nu14020383Clinical Impact of Nutritional Status and Sarcopenia in Pediatric Patients with Bone and Soft Tissue Sarcomas: A Pilot Retrospective Study (SarcoPed)Alberto Romano0Silvia Triarico1Emanuele Rinninella2Luigi Natale3Maria Gabriella Brizi4Marco Cintoni5Pauline Raoul6Palma Maurizi7Giorgio Attinà8Stefano Mastrangelo9Antonio Gasbarrini10Maria Cristina Mele11Antonio Ruggiero12UOSD di Oncologia Pediatrica, Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyUOSD di Oncologia Pediatrica, Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyUOC di Nutrizione Clinica, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyDipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyDipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyUOC di Nutrizione Clinica, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, ItalyUOSD di Oncologia Pediatrica, Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyUOSD di Oncologia Pediatrica, Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyUOSD di Oncologia Pediatrica, Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, ItalyUOC di Nutrizione Clinica, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyUOSD di Oncologia Pediatrica, Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyBackground: We evaluated nutritional and sarcopenia status and their clinical impact in pediatric patients affected by bone and soft tissue sarcomas. Methods: Body mass index (BMI), prognostic nutritional index (PNI), and total psoas muscle area (tPMA) at diagnosis and after 12 months were analyzed. tPMA was measured from single cross-sectional computed tomography (CT) images at L4–L5. Age-specific and sex-specific tPMA Z-scores were retrieved from an online calculator. Results: A total of 21 patients were identified between February 2013 and December 2018. Twelve patients (57.1%) experienced sarcopenia at diagnosis, although not statistically associated with overall survival (OS) (<i>p</i> = 0.09). BMI Z-score, PNI, and tPMA Z-score significantly decreased between diagnosis and after 12 months of treatment (<i>p</i> < 0.05). Univariate analysis showed significant associations between poor OS and the presence of metastasis (<i>p</i> = 0.008), the absence of surgery (<i>p</i> = 0.005), PNI decrease (<i>p</i> = 0.027), and the reduction in tPMA > 25% (<i>p</i> = 0.042) over the 12 months. Conclusions: Sarcopenia affects more than half of the patients at diagnosis. Decreased PNI during 12 months of treatment has significant predictive value for OS. The role of tPMA derived from CT scan among pediatric patients with sarcoma should be investigated in further prospective and larger studies.https://www.mdpi.com/2072-6643/14/2/383soft tissue sarcomabone sarcomapediatric patientschemotherapypsoas muscle area (PMA)sarcopenia |
| spellingShingle | Alberto Romano Silvia Triarico Emanuele Rinninella Luigi Natale Maria Gabriella Brizi Marco Cintoni Pauline Raoul Palma Maurizi Giorgio Attinà Stefano Mastrangelo Antonio Gasbarrini Maria Cristina Mele Antonio Ruggiero Clinical Impact of Nutritional Status and Sarcopenia in Pediatric Patients with Bone and Soft Tissue Sarcomas: A Pilot Retrospective Study (SarcoPed) Nutrients soft tissue sarcoma bone sarcoma pediatric patients chemotherapy psoas muscle area (PMA) sarcopenia |
| title | Clinical Impact of Nutritional Status and Sarcopenia in Pediatric Patients with Bone and Soft Tissue Sarcomas: A Pilot Retrospective Study (SarcoPed) |
| title_full | Clinical Impact of Nutritional Status and Sarcopenia in Pediatric Patients with Bone and Soft Tissue Sarcomas: A Pilot Retrospective Study (SarcoPed) |
| title_fullStr | Clinical Impact of Nutritional Status and Sarcopenia in Pediatric Patients with Bone and Soft Tissue Sarcomas: A Pilot Retrospective Study (SarcoPed) |
| title_full_unstemmed | Clinical Impact of Nutritional Status and Sarcopenia in Pediatric Patients with Bone and Soft Tissue Sarcomas: A Pilot Retrospective Study (SarcoPed) |
| title_short | Clinical Impact of Nutritional Status and Sarcopenia in Pediatric Patients with Bone and Soft Tissue Sarcomas: A Pilot Retrospective Study (SarcoPed) |
| title_sort | clinical impact of nutritional status and sarcopenia in pediatric patients with bone and soft tissue sarcomas a pilot retrospective study sarcoped |
| topic | soft tissue sarcoma bone sarcoma pediatric patients chemotherapy psoas muscle area (PMA) sarcopenia |
| url | https://www.mdpi.com/2072-6643/14/2/383 |
| work_keys_str_mv | AT albertoromano clinicalimpactofnutritionalstatusandsarcopeniainpediatricpatientswithboneandsofttissuesarcomasapilotretrospectivestudysarcoped AT silviatriarico clinicalimpactofnutritionalstatusandsarcopeniainpediatricpatientswithboneandsofttissuesarcomasapilotretrospectivestudysarcoped AT emanuelerinninella clinicalimpactofnutritionalstatusandsarcopeniainpediatricpatientswithboneandsofttissuesarcomasapilotretrospectivestudysarcoped AT luiginatale clinicalimpactofnutritionalstatusandsarcopeniainpediatricpatientswithboneandsofttissuesarcomasapilotretrospectivestudysarcoped AT mariagabriellabrizi clinicalimpactofnutritionalstatusandsarcopeniainpediatricpatientswithboneandsofttissuesarcomasapilotretrospectivestudysarcoped AT marcocintoni clinicalimpactofnutritionalstatusandsarcopeniainpediatricpatientswithboneandsofttissuesarcomasapilotretrospectivestudysarcoped AT paulineraoul clinicalimpactofnutritionalstatusandsarcopeniainpediatricpatientswithboneandsofttissuesarcomasapilotretrospectivestudysarcoped AT palmamaurizi clinicalimpactofnutritionalstatusandsarcopeniainpediatricpatientswithboneandsofttissuesarcomasapilotretrospectivestudysarcoped AT giorgioattina clinicalimpactofnutritionalstatusandsarcopeniainpediatricpatientswithboneandsofttissuesarcomasapilotretrospectivestudysarcoped AT stefanomastrangelo clinicalimpactofnutritionalstatusandsarcopeniainpediatricpatientswithboneandsofttissuesarcomasapilotretrospectivestudysarcoped AT antoniogasbarrini clinicalimpactofnutritionalstatusandsarcopeniainpediatricpatientswithboneandsofttissuesarcomasapilotretrospectivestudysarcoped AT mariacristinamele clinicalimpactofnutritionalstatusandsarcopeniainpediatricpatientswithboneandsofttissuesarcomasapilotretrospectivestudysarcoped AT antonioruggiero clinicalimpactofnutritionalstatusandsarcopeniainpediatricpatientswithboneandsofttissuesarcomasapilotretrospectivestudysarcoped |