Pregnancy in acromegaly
With advances in surgical and medical treatment and the availability of assisted reproductive techniques, pregnancy in women with acromegaly is more frequently encountered. Diagnosis of acromegaly during pregnancy is difficult because of changes in growth hormone and insulin like growth factor-1 (IG...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-12-01
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| Series: | Therapeutic Advances in Endocrinology and Metabolism |
| Online Access: | https://doi.org/10.1177/2042018815603927 |
| _version_ | 1818323171518971904 |
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| author | Bashir A. Laway |
| author_facet | Bashir A. Laway |
| author_sort | Bashir A. Laway |
| collection | DOAJ |
| description | With advances in surgical and medical treatment and the availability of assisted reproductive techniques, pregnancy in women with acromegaly is more frequently encountered. Diagnosis of acromegaly during pregnancy is difficult because of changes in growth hormone and insulin like growth factor-1 (IGF-1) axis secondary to placental production of growth hormone. The difficulty is compounded by the inability of routine hormone assays to detect placental growth hormone. In the majority of patients with acromegaly, pregnancy does not have an adverse effect on mother or fetus and pituitary mass does not increase in size. The level of IGF-1 usually remains stable because of the effect of estrogen causing a growth hormone resistant state. In patients with pituitary macroadenoma, the possibility of an increase in size of the pituitary mass needs to be kept in mind and more frequent monitoring is required. In case of tumor enlargement, pituitary surgery can be considered in the mid trimester. Experience with the use of medical treatment for acromegaly during pregnancy is increasing. Dopamine agonists, somatostatin analogs or growth hormone receptor antagonists have been used without any adverse consequences on mother or fetus. At present, it is advisable to stop any medical treatment after confirmation of pregnancy till more data are available on the safety of these drugs. |
| first_indexed | 2024-12-13T11:08:27Z |
| format | Article |
| id | doaj.art-eed704b6e2024f0194b1704b55d88e1c |
| institution | Directory Open Access Journal |
| issn | 2042-0188 2042-0196 |
| language | English |
| last_indexed | 2024-12-13T11:08:27Z |
| publishDate | 2015-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Endocrinology and Metabolism |
| spelling | doaj.art-eed704b6e2024f0194b1704b55d88e1c2022-12-21T23:48:53ZengSAGE PublishingTherapeutic Advances in Endocrinology and Metabolism2042-01882042-01962015-12-01610.1177/2042018815603927Pregnancy in acromegalyBashir A. LawayWith advances in surgical and medical treatment and the availability of assisted reproductive techniques, pregnancy in women with acromegaly is more frequently encountered. Diagnosis of acromegaly during pregnancy is difficult because of changes in growth hormone and insulin like growth factor-1 (IGF-1) axis secondary to placental production of growth hormone. The difficulty is compounded by the inability of routine hormone assays to detect placental growth hormone. In the majority of patients with acromegaly, pregnancy does not have an adverse effect on mother or fetus and pituitary mass does not increase in size. The level of IGF-1 usually remains stable because of the effect of estrogen causing a growth hormone resistant state. In patients with pituitary macroadenoma, the possibility of an increase in size of the pituitary mass needs to be kept in mind and more frequent monitoring is required. In case of tumor enlargement, pituitary surgery can be considered in the mid trimester. Experience with the use of medical treatment for acromegaly during pregnancy is increasing. Dopamine agonists, somatostatin analogs or growth hormone receptor antagonists have been used without any adverse consequences on mother or fetus. At present, it is advisable to stop any medical treatment after confirmation of pregnancy till more data are available on the safety of these drugs.https://doi.org/10.1177/2042018815603927 |
| spellingShingle | Bashir A. Laway Pregnancy in acromegaly Therapeutic Advances in Endocrinology and Metabolism |
| title | Pregnancy in acromegaly |
| title_full | Pregnancy in acromegaly |
| title_fullStr | Pregnancy in acromegaly |
| title_full_unstemmed | Pregnancy in acromegaly |
| title_short | Pregnancy in acromegaly |
| title_sort | pregnancy in acromegaly |
| url | https://doi.org/10.1177/2042018815603927 |
| work_keys_str_mv | AT bashiralaway pregnancyinacromegaly |