Pharmacokinetic/pharmacodynamic based dosing of ciprofloxacin in complicated urinary tract infections
Ciprofloxacin is often used in treatment of complicated urinary tract infections in areas with high rates of resistance to first line agents. The aim of this study was to evaluate efficacy of ciprofloxacin in standard dosing regimens in treatment of complicated urinary tract infections. Plasma conce...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2015-07-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/23604 |
| _version_ | 1828837562911817728 |
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| author | Ana Sabo Ana Tomas Nataa Tomi? Momir Mikov Olga Horvat Radmila Popovi? Zdenko Tomi? |
| author_facet | Ana Sabo Ana Tomas Nataa Tomi? Momir Mikov Olga Horvat Radmila Popovi? Zdenko Tomi? |
| author_sort | Ana Sabo |
| collection | DOAJ |
| description | Ciprofloxacin is often used in treatment of complicated urinary tract infections in areas with high rates of resistance to first line agents. The aim of this study was to evaluate efficacy of ciprofloxacin in standard dosing regimens in treatment of complicated urinary tract infections. Plasma concentration curves were simulated and minimum inhibitory concentration (MIC) and post-antibiotic effect were determined. Ciprofloxacin MIC ranged from 0.0156 for Gram-negative and to 0.125-0.5 µg/mL for Gram-positive bacteria. Both dosing regimens were suitable for eradication of Gram-negative bacteria, with slight supremacy of 750 mg/12 hours over 500 mg/12 hours dosing regimen. Even though all strains were fully susceptible to ciprofloxacin, pharmaco-kinetic/pharmacodynamic parameters did not meet target thresholds for pathogens with MIC over 0.1-0.2 µg/mL regardless of the administered dose. Ciprofloxacin remains an excellent choice for treatment of complicated urinary tract infections caused by Gram-negative bacteria, but in infection caused by Gram-positive strains, deeper analysis is necessary in order to achieve optimal results. |
| first_indexed | 2024-12-12T18:44:47Z |
| format | Article |
| id | doaj.art-eed71a149aba4c7d99da35f6b04b2912 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-12T18:44:47Z |
| publishDate | 2015-07-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-eed71a149aba4c7d99da35f6b04b29122022-12-22T00:15:34ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882015-07-0110310.3329/bjp.v10i3.23604Pharmacokinetic/pharmacodynamic based dosing of ciprofloxacin in complicated urinary tract infectionsAna Sabo0Ana Tomas1Nataa Tomi?2Momir Mikov3Olga Horvat4Radmila Popovi?5Zdenko Tomi?6Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi SadDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi SadInstitute of Emergency medicine, Clinical Centre of Vojvodina, Novi SadDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi SadDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi SadClinic for Anesthesia and Intensive Care, Clinical Centre of Vojvodina, Novi SadDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi SadCiprofloxacin is often used in treatment of complicated urinary tract infections in areas with high rates of resistance to first line agents. The aim of this study was to evaluate efficacy of ciprofloxacin in standard dosing regimens in treatment of complicated urinary tract infections. Plasma concentration curves were simulated and minimum inhibitory concentration (MIC) and post-antibiotic effect were determined. Ciprofloxacin MIC ranged from 0.0156 for Gram-negative and to 0.125-0.5 µg/mL for Gram-positive bacteria. Both dosing regimens were suitable for eradication of Gram-negative bacteria, with slight supremacy of 750 mg/12 hours over 500 mg/12 hours dosing regimen. Even though all strains were fully susceptible to ciprofloxacin, pharmaco-kinetic/pharmacodynamic parameters did not meet target thresholds for pathogens with MIC over 0.1-0.2 µg/mL regardless of the administered dose. Ciprofloxacin remains an excellent choice for treatment of complicated urinary tract infections caused by Gram-negative bacteria, but in infection caused by Gram-positive strains, deeper analysis is necessary in order to achieve optimal results.https://www.banglajol.info/index.php/BJP/article/view/23604CiprofloxacinComplicated urinary tract infectionsPharmacokineticsPharmacodynamics |
| spellingShingle | Ana Sabo Ana Tomas Nataa Tomi? Momir Mikov Olga Horvat Radmila Popovi? Zdenko Tomi? Pharmacokinetic/pharmacodynamic based dosing of ciprofloxacin in complicated urinary tract infections Bangladesh Journal of Pharmacology Ciprofloxacin Complicated urinary tract infections Pharmacokinetics Pharmacodynamics |
| title | Pharmacokinetic/pharmacodynamic based dosing of ciprofloxacin in complicated urinary tract infections |
| title_full | Pharmacokinetic/pharmacodynamic based dosing of ciprofloxacin in complicated urinary tract infections |
| title_fullStr | Pharmacokinetic/pharmacodynamic based dosing of ciprofloxacin in complicated urinary tract infections |
| title_full_unstemmed | Pharmacokinetic/pharmacodynamic based dosing of ciprofloxacin in complicated urinary tract infections |
| title_short | Pharmacokinetic/pharmacodynamic based dosing of ciprofloxacin in complicated urinary tract infections |
| title_sort | pharmacokinetic pharmacodynamic based dosing of ciprofloxacin in complicated urinary tract infections |
| topic | Ciprofloxacin Complicated urinary tract infections Pharmacokinetics Pharmacodynamics |
| url | https://www.banglajol.info/index.php/BJP/article/view/23604 |
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