Levels of interleukins 2, 6, 8, and 10 in patients with irritable bowel syndrome
Irritable bowel syndrome (IBS) was previously considered as a psychosomatic disorder. But recent studies indicate that inflammation plays a significant role. The present study was undertaken to evaluate role of pro-inflammatory (IL 2, IL 6 and IL 8) and anti-inflammatory (IL 10) cytokines in clinica...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2017;volume=60;issue=3;spage=385;epage=389;aulast=Patel |
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| author | Shaileshkumar R Patel Anshul Singh Vatsala Misra Sri Prakash Misra Manisha Dwivedi Pawan Trivedi |
| author_facet | Shaileshkumar R Patel Anshul Singh Vatsala Misra Sri Prakash Misra Manisha Dwivedi Pawan Trivedi |
| author_sort | Shaileshkumar R Patel |
| collection | DOAJ |
| description | Irritable bowel syndrome (IBS) was previously considered as a psychosomatic disorder. But recent studies indicate that inflammation plays a significant role. The present study was undertaken to evaluate role of pro-inflammatory (IL 2, IL 6 and IL 8) and anti-inflammatory (IL 10) cytokines in clinically diagnosed patients of IBS. 51 patients and 29 controls were included in this study. On the basis of history of gastrointestinal infection, patients were divided into Post Infectious (PIIBS) and Non Post Infectious (NPIIBS) groups. All subsequently underwent colonoscopy and a rectosigmoid biopsy as well as measurement of levels of IL 2, 6, 8 and 10. The levels of IL 2 and IL 8 were significantly raised in IBS patients compared to controls with the mean level of IL 2,6 and 8 higher in PIIBS group than NPIIBS group but statistically significant for IL 8 only. The mean level IL-10 was reduced in patients compared to controls but statistically insignificant. Present study shows that Interleukin levels are altered in patients suffering from IBS and may have a key role in its pathogenesis. |
| first_indexed | 2024-12-10T14:21:46Z |
| format | Article |
| id | doaj.art-eed932335d624a4da0c5d20bee5e0aeb |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-10T14:21:46Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-eed932335d624a4da0c5d20bee5e0aeb2022-12-22T01:45:10ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292017-01-0160338538910.4103/IJPM.IJPM_544_16Levels of interleukins 2, 6, 8, and 10 in patients with irritable bowel syndromeShaileshkumar R PatelAnshul SinghVatsala MisraSri Prakash MisraManisha DwivediPawan TrivediIrritable bowel syndrome (IBS) was previously considered as a psychosomatic disorder. But recent studies indicate that inflammation plays a significant role. The present study was undertaken to evaluate role of pro-inflammatory (IL 2, IL 6 and IL 8) and anti-inflammatory (IL 10) cytokines in clinically diagnosed patients of IBS. 51 patients and 29 controls were included in this study. On the basis of history of gastrointestinal infection, patients were divided into Post Infectious (PIIBS) and Non Post Infectious (NPIIBS) groups. All subsequently underwent colonoscopy and a rectosigmoid biopsy as well as measurement of levels of IL 2, 6, 8 and 10. The levels of IL 2 and IL 8 were significantly raised in IBS patients compared to controls with the mean level of IL 2,6 and 8 higher in PIIBS group than NPIIBS group but statistically significant for IL 8 only. The mean level IL-10 was reduced in patients compared to controls but statistically insignificant. Present study shows that Interleukin levels are altered in patients suffering from IBS and may have a key role in its pathogenesis.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2017;volume=60;issue=3;spage=385;epage=389;aulast=PatelCytokinesinflammationinterleukinsirritable bowel syndromepathogenesis |
| spellingShingle | Shaileshkumar R Patel Anshul Singh Vatsala Misra Sri Prakash Misra Manisha Dwivedi Pawan Trivedi Levels of interleukins 2, 6, 8, and 10 in patients with irritable bowel syndrome Indian Journal of Pathology and Microbiology Cytokines inflammation interleukins irritable bowel syndrome pathogenesis |
| title | Levels of interleukins 2, 6, 8, and 10 in patients with irritable bowel syndrome |
| title_full | Levels of interleukins 2, 6, 8, and 10 in patients with irritable bowel syndrome |
| title_fullStr | Levels of interleukins 2, 6, 8, and 10 in patients with irritable bowel syndrome |
| title_full_unstemmed | Levels of interleukins 2, 6, 8, and 10 in patients with irritable bowel syndrome |
| title_short | Levels of interleukins 2, 6, 8, and 10 in patients with irritable bowel syndrome |
| title_sort | levels of interleukins 2 6 8 and 10 in patients with irritable bowel syndrome |
| topic | Cytokines inflammation interleukins irritable bowel syndrome pathogenesis |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2017;volume=60;issue=3;spage=385;epage=389;aulast=Patel |
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