Enantioselective Synthesis of (+)-Coerulescine by a Phase-Transfer Catalytic Allylation of Diphenylmethyl tert-Butyl α-(2-Nitrophenyl)Malonate

Enantioselective Synthesis of (+)-Coerulescine by a Phase-Transfer Catalytic Allylation of Diphenylmethyl tert-Butyl α-(2-Nitrophenyl)Malonate

A 7-step enantioselective synthetic method for preparing (S)(+)-coerulescine is reported through the use of diphenylmethyl tert-butyl α-(2-nitrophenyl)malonate (16% overall yield, >99% ee). Allylation is the key step under phase-transfer catalytic conditions (86% ee). This synthetic method ca...

Full description

Bibliographic Details
Main Authors: Sangki Lee, Jewon Yang, Sehun Yang, Geumwoo Lee, Daehyun Oh, Min Woo Ha, Suckchang Hong, Hyeung-geun Park
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Chemistry
Subjects:
coerulescine
enantioselective
synthesis
phase-transfer catalysis
alkylation
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2020.577371/full

Similar Items

Similar Items