Alternative Splicing: A Key Mediator of Diabetic Vasculopathy
Cardiovascular disease is the leading cause of death amongst diabetic individuals. Atherosclerosis is the prominent driver of diabetic vascular complications, which is triggered by the detrimental effects of hyperglycemia and oxidative stress on the vasculature. Research has extensively shown diabet...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/9/1332 |
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| author | Victoria A. Cornelius Jenna R. Fulton Andriana Margariti |
| author_facet | Victoria A. Cornelius Jenna R. Fulton Andriana Margariti |
| author_sort | Victoria A. Cornelius |
| collection | DOAJ |
| description | Cardiovascular disease is the leading cause of death amongst diabetic individuals. Atherosclerosis is the prominent driver of diabetic vascular complications, which is triggered by the detrimental effects of hyperglycemia and oxidative stress on the vasculature. Research has extensively shown diabetes to result in the malfunction of the endothelium, the main component of blood vessels, causing severe vascular complications. The pathogenic mechanism in which diabetes induces vascular dysfunction, however, remains largely unclear. Alternative splicing of protein coding pre-mRNAs is an essential regulatory mechanism of gene expression and is accepted to be intertwined with cellular physiology. Recently, a role for alternative splicing has arisen within vascular health, with aberrant mis-splicing having a critical role in disease development, including in atherosclerosis. This review focuses on the current knowledge of alternative splicing and the roles of alternatively spliced isoforms within the vasculature, with a particular focus on disease states. Furthermore, we explore the recent elucidation of the alternatively spliced QKI gene within vascular cell physiology and the onset of diabetic vasculopathy. Potential therapeutic strategies to restore aberrant splicing are also discussed. |
| first_indexed | 2024-03-10T07:39:10Z |
| format | Article |
| id | doaj.art-eedbb4b7418547c29ad7ec7897befcdb |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T07:39:10Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-eedbb4b7418547c29ad7ec7897befcdb2023-11-22T13:13:25ZengMDPI AGGenes2073-44252021-08-01129133210.3390/genes12091332Alternative Splicing: A Key Mediator of Diabetic VasculopathyVictoria A. Cornelius0Jenna R. Fulton1Andriana Margariti2The Wellcome-Wolfson Institute of Experimental Medicine, Belfast BT9 7BL, UKThe Wellcome-Wolfson Institute of Experimental Medicine, Belfast BT9 7BL, UKThe Wellcome-Wolfson Institute of Experimental Medicine, Belfast BT9 7BL, UKCardiovascular disease is the leading cause of death amongst diabetic individuals. Atherosclerosis is the prominent driver of diabetic vascular complications, which is triggered by the detrimental effects of hyperglycemia and oxidative stress on the vasculature. Research has extensively shown diabetes to result in the malfunction of the endothelium, the main component of blood vessels, causing severe vascular complications. The pathogenic mechanism in which diabetes induces vascular dysfunction, however, remains largely unclear. Alternative splicing of protein coding pre-mRNAs is an essential regulatory mechanism of gene expression and is accepted to be intertwined with cellular physiology. Recently, a role for alternative splicing has arisen within vascular health, with aberrant mis-splicing having a critical role in disease development, including in atherosclerosis. This review focuses on the current knowledge of alternative splicing and the roles of alternatively spliced isoforms within the vasculature, with a particular focus on disease states. Furthermore, we explore the recent elucidation of the alternatively spliced QKI gene within vascular cell physiology and the onset of diabetic vasculopathy. Potential therapeutic strategies to restore aberrant splicing are also discussed.https://www.mdpi.com/2073-4425/12/9/1332alternative splicingcardiovascular diseasediabetic vasculopathyatherosclerosisisoformsquaking |
| spellingShingle | Victoria A. Cornelius Jenna R. Fulton Andriana Margariti Alternative Splicing: A Key Mediator of Diabetic Vasculopathy Genes alternative splicing cardiovascular disease diabetic vasculopathy atherosclerosis isoforms quaking |
| title | Alternative Splicing: A Key Mediator of Diabetic Vasculopathy |
| title_full | Alternative Splicing: A Key Mediator of Diabetic Vasculopathy |
| title_fullStr | Alternative Splicing: A Key Mediator of Diabetic Vasculopathy |
| title_full_unstemmed | Alternative Splicing: A Key Mediator of Diabetic Vasculopathy |
| title_short | Alternative Splicing: A Key Mediator of Diabetic Vasculopathy |
| title_sort | alternative splicing a key mediator of diabetic vasculopathy |
| topic | alternative splicing cardiovascular disease diabetic vasculopathy atherosclerosis isoforms quaking |
| url | https://www.mdpi.com/2073-4425/12/9/1332 |
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