Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities
Chemotherapeutic drugs are primarily administered to cancer patients via oral or parenteral routes. The use of transdermal drug delivery could potentially be a better alternative to decrease the dose frequency and severity of adverse or toxic effects associated with oral or parenteral administration...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/7/960 |
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| author | Rabin Neupane Sai H. S. Boddu Mariam Sami Abou-Dahech Rinda Devi Bachu David Terrero R. Jayachandra Babu Amit K. Tiwari |
| author_facet | Rabin Neupane Sai H. S. Boddu Mariam Sami Abou-Dahech Rinda Devi Bachu David Terrero R. Jayachandra Babu Amit K. Tiwari |
| author_sort | Rabin Neupane |
| collection | DOAJ |
| description | Chemotherapeutic drugs are primarily administered to cancer patients via oral or parenteral routes. The use of transdermal drug delivery could potentially be a better alternative to decrease the dose frequency and severity of adverse or toxic effects associated with oral or parenteral administration of chemotherapeutic drugs. The transdermal delivery of drugs has shown to be advantageous for the treatment of highly localized tumors in certain types of breast and skin cancers. In addition, the transdermal route can be used to deliver low-dose chemotherapeutics in a sustained manner. The transdermal route can also be utilized for vaccine design in cancer management, for example, vaccines against cervical cancer. However, the design of transdermal formulations may be challenging in terms of the conjugation chemistry of the molecules and the sustained and reproducible delivery of therapeutically efficacious doses. In this review, we discuss the nano-carrier systems, such as nanoparticles, liposomes, etc., used in recent literature to deliver chemotherapeutic agents. The advantages of transdermal route over oral and parenteral routes for popular chemotherapeutic drugs are summarized. Furthermore, we also discuss a possible in silico approach, Formulating for Efficacy™, to design transdermal formulations that would probably be economical, robust, and more efficacious. |
| first_indexed | 2024-03-10T10:02:08Z |
| format | Article |
| id | doaj.art-eedbc183f6714321add265de617b63cb |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T10:02:08Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-eedbc183f6714321add265de617b63cb2023-11-22T01:51:01ZengMDPI AGPharmaceutics1999-49232021-06-0113796010.3390/pharmaceutics13070960Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and OpportunitiesRabin Neupane0Sai H. S. Boddu1Mariam Sami Abou-Dahech2Rinda Devi Bachu3David Terrero4R. Jayachandra Babu5Amit K. Tiwari6Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH 43614, USACollege of Pharmacy and Health Sciences, Ajman University, Ajman 346, United Arab EmiratesDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH 43614, USADepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH 43614, USADepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH 43614, USADepartment of Drug Discovery & Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USADepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH 43614, USAChemotherapeutic drugs are primarily administered to cancer patients via oral or parenteral routes. The use of transdermal drug delivery could potentially be a better alternative to decrease the dose frequency and severity of adverse or toxic effects associated with oral or parenteral administration of chemotherapeutic drugs. The transdermal delivery of drugs has shown to be advantageous for the treatment of highly localized tumors in certain types of breast and skin cancers. In addition, the transdermal route can be used to deliver low-dose chemotherapeutics in a sustained manner. The transdermal route can also be utilized for vaccine design in cancer management, for example, vaccines against cervical cancer. However, the design of transdermal formulations may be challenging in terms of the conjugation chemistry of the molecules and the sustained and reproducible delivery of therapeutically efficacious doses. In this review, we discuss the nano-carrier systems, such as nanoparticles, liposomes, etc., used in recent literature to deliver chemotherapeutic agents. The advantages of transdermal route over oral and parenteral routes for popular chemotherapeutic drugs are summarized. Furthermore, we also discuss a possible in silico approach, Formulating for Efficacy™, to design transdermal formulations that would probably be economical, robust, and more efficacious.https://www.mdpi.com/1999-4923/13/7/960chemotherapeuticsmelanomabreast cancernanoparticlesliposomestransdermal vaccine |
| spellingShingle | Rabin Neupane Sai H. S. Boddu Mariam Sami Abou-Dahech Rinda Devi Bachu David Terrero R. Jayachandra Babu Amit K. Tiwari Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities Pharmaceutics chemotherapeutics melanoma breast cancer nanoparticles liposomes transdermal vaccine |
| title | Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities |
| title_full | Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities |
| title_fullStr | Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities |
| title_full_unstemmed | Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities |
| title_short | Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities |
| title_sort | transdermal delivery of chemotherapeutics strategies requirements and opportunities |
| topic | chemotherapeutics melanoma breast cancer nanoparticles liposomes transdermal vaccine |
| url | https://www.mdpi.com/1999-4923/13/7/960 |
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