Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications
Microneedle array systems loaded with responsive nanoparticles have received increasing attention due to the advantages of good drug stability, targeting ability, controlled release of drugs, high bioavailability, painlessness, and good patient compliance. Compared with oral drug delivery, microneed...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2024-04-01
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| Series: | Advanced NanoBiomed Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/anbr.202300142 |
| _version_ | 1797215125737832448 |
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| author | Rixin Xie Wenjing Li Kexin Shi Li Yang Hongzhong Chen Shaoyun Jiang Xiaowei Zeng |
| author_facet | Rixin Xie Wenjing Li Kexin Shi Li Yang Hongzhong Chen Shaoyun Jiang Xiaowei Zeng |
| author_sort | Rixin Xie |
| collection | DOAJ |
| description | Microneedle array systems loaded with responsive nanoparticles have received increasing attention due to the advantages of good drug stability, targeting ability, controlled release of drugs, high bioavailability, painlessness, and good patient compliance. Compared with oral drug delivery, microneedle transdermal drug delivery eliminates the need to pass through the gastrointestinal tract and liver, reducing the metabolic consumption of drugs by first‐pass effect. While compared with intravenous drug delivery, microneedle transdermal drug delivery reduces patient discomfort and does not require professional administration. However, there are few review articles on microneedles loaded with responsive nanoparticles. Herein, the current researches on microneedles loaded with specific responsive nanoparticles such as glucose‐responsive, pH‐responsive, enzyme‐responsive, light‐responsive, magnetic‐responsive, ultrasound‐responsive, and multiresponsive, and the biomedical application of these microneedle array systems are summarized. In addition, the challenges and prospects of microneedle strategies loaded with responsive nanoparticles are briefly discussed, which will facilitate the development of such versatile drug‐delivery strategy. |
| first_indexed | 2024-04-24T11:25:06Z |
| format | Article |
| id | doaj.art-eedc4acb6c854a6eb8625a4e39921e0d |
| institution | Directory Open Access Journal |
| issn | 2699-9307 |
| language | English |
| last_indexed | 2024-04-24T11:25:06Z |
| publishDate | 2024-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj.art-eedc4acb6c854a6eb8625a4e39921e0d2024-04-11T02:58:25ZengWiley-VCHAdvanced NanoBiomed Research2699-93072024-04-0144n/an/a10.1002/anbr.202300142Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical ApplicationsRixin Xie0Wenjing Li1Kexin Shi2Li Yang3Hongzhong Chen4Shaoyun Jiang5Xiaowei Zeng6School of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat‐sen University Shenzhen 518107 ChinaSchool of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat‐sen University Shenzhen 518107 ChinaSchool of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat‐sen University Shenzhen 518107 ChinaSchool of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat‐sen University Shenzhen 518107 ChinaSchool of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat‐sen University Shenzhen 518107 ChinaStomatological Center Peking University Shenzhen Hospital Guangdong Province Engineering Research Center of Oral Disease Diagnosis and Treatment Shenzhen 518036 ChinaSchool of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat‐sen University Shenzhen 518107 ChinaMicroneedle array systems loaded with responsive nanoparticles have received increasing attention due to the advantages of good drug stability, targeting ability, controlled release of drugs, high bioavailability, painlessness, and good patient compliance. Compared with oral drug delivery, microneedle transdermal drug delivery eliminates the need to pass through the gastrointestinal tract and liver, reducing the metabolic consumption of drugs by first‐pass effect. While compared with intravenous drug delivery, microneedle transdermal drug delivery reduces patient discomfort and does not require professional administration. However, there are few review articles on microneedles loaded with responsive nanoparticles. Herein, the current researches on microneedles loaded with specific responsive nanoparticles such as glucose‐responsive, pH‐responsive, enzyme‐responsive, light‐responsive, magnetic‐responsive, ultrasound‐responsive, and multiresponsive, and the biomedical application of these microneedle array systems are summarized. In addition, the challenges and prospects of microneedle strategies loaded with responsive nanoparticles are briefly discussed, which will facilitate the development of such versatile drug‐delivery strategy.https://doi.org/10.1002/anbr.202300142biomedical applicationsdisease treatmentsmicroneedlesresponsive nanoparticles |
| spellingShingle | Rixin Xie Wenjing Li Kexin Shi Li Yang Hongzhong Chen Shaoyun Jiang Xiaowei Zeng Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications Advanced NanoBiomed Research biomedical applications disease treatments microneedles responsive nanoparticles |
| title | Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications |
| title_full | Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications |
| title_fullStr | Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications |
| title_full_unstemmed | Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications |
| title_short | Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications |
| title_sort | versatile platforms of microneedle patches loaded with responsive nanoparticles synthesis and promising biomedical applications |
| topic | biomedical applications disease treatments microneedles responsive nanoparticles |
| url | https://doi.org/10.1002/anbr.202300142 |
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