Biochemical aspects of KB-28 compound on physically loaded study subjects
In previous studies of actoprotective activity of 5-R-thio-tetrazolo[1,5]quinazoline derivatives in normal and complicated experimental conditions, sodium 2-(tetrazolo [1,5-c]quinazoline-5-ylthio)acetate (KB-28) was found to be the leader of the experiment. The objective of the current study was to...
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| Format: | Article |
| Language: | English |
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Sciendo
2019-09-01
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| Series: | Current Issues in Pharmacy and Medical Sciences |
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| Online Access: | https://doi.org/10.2478/cipms-2019-0030 |
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| author | Toziuk Olena Krasna Olga Kryvoviaz Olena Rodinkova Victoria Melnyk Andrii Ivko Tanya Voronkina Alona Hutsol Viktoriia |
| author_facet | Toziuk Olena Krasna Olga Kryvoviaz Olena Rodinkova Victoria Melnyk Andrii Ivko Tanya Voronkina Alona Hutsol Viktoriia |
| author_sort | Toziuk Olena |
| collection | DOAJ |
| description | In previous studies of actoprotective activity of 5-R-thio-tetrazolo[1,5]quinazoline derivatives in normal and complicated experimental conditions, sodium 2-(tetrazolo [1,5-c]quinazoline-5-ylthio)acetate (KB-28) was found to be the leader of the experiment. The objective of the current study was to characterize the effects of KB-28 compounds on carbohydrate and lipid exchange indices under the conditions of physical load as a possible mechanism of actoprotective effect. In the course of the experiment, the indices of carbohydrate and lipid exchange in the muscle, blood and liver of animal models were determined following a 15-day physical load course. In doing so, glucose, glycogen and total lipid concentrations were assessed. The KB-28 compound was administered daily at levels determined during the course of regular physical load normalized metabolic processes in rats. The results were then compared to a control which received intraperitoneally the equivolume 0.9% sodium chloride solution. The phenomenon of actoprotection consisted in enhancing concentrations of glycogen in skeletal muscles and liver. Compared to the control figures, this increase was 28.8% and 25.0%, accordingly. Moreover, the course of KB-28 caused a statistically significant reduction (by 32.1%) of the total serum lipid concentration in the animals under physical load. The effect may be a sign of the ability of this substance to utilize active lipolysis for improvement of the skeletal muscle performance. Having analyzed the results obtained, we can draw a conclusion that influencing the biochemical processes in the study models is one of the mechanisms of the KB-28 actoprotective effect. |
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| issn | 2084-980X 2300-6676 |
| language | English |
| last_indexed | 2024-12-17T12:37:56Z |
| publishDate | 2019-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Current Issues in Pharmacy and Medical Sciences |
| spelling | doaj.art-eedd969b6d474033a01f29b402d04b0b2022-12-21T21:48:11ZengSciendoCurrent Issues in Pharmacy and Medical Sciences2084-980X2300-66762019-09-0132316817210.2478/cipms-2019-0030cipms-2019-0030Biochemical aspects of KB-28 compound on physically loaded study subjectsToziuk Olena0Krasna Olga1Kryvoviaz Olena2Rodinkova Victoria3Melnyk Andrii4Ivko Tanya5Voronkina Alona6Hutsol Viktoriia7Pharmacy Department, National Pirogov Memorial Medical University, Vinnytsya, Pirogov 56, Vinnytsia, UkraineGeneral Pharmacy Department, Odessa National Medical University, Valikhovsky Lane 2, Odessa, UkrainePharmacy Department, National Pirogov Memorial Medical University, Vinnytsya, Pirogov 56, Vinnytsia, UkrainePharmacy Department, National Pirogov Memorial Medical University, Vinnytsya, Pirogov 56, Vinnytsia, UkraineDepartment of Biological and General Chemistry, National Pirogov Memorial Medical University, Vinnytsya, Pirogov 56, Vinnytsia, UkrainePharmacy Department, National Pirogov Memorial Medical University, Vinnytsya, Pirogov 56, Vinnytsia, UkrainePharmacy Department, National Pirogov Memorial Medical University, Vinnytsya, Pirogov 56, Vinnytsia, UkrainePharmacy Department, National Pirogov Memorial Medical University, Vinnytsya, Pirogov 56, Vinnytsia, UkraineIn previous studies of actoprotective activity of 5-R-thio-tetrazolo[1,5]quinazoline derivatives in normal and complicated experimental conditions, sodium 2-(tetrazolo [1,5-c]quinazoline-5-ylthio)acetate (KB-28) was found to be the leader of the experiment. The objective of the current study was to characterize the effects of KB-28 compounds on carbohydrate and lipid exchange indices under the conditions of physical load as a possible mechanism of actoprotective effect. In the course of the experiment, the indices of carbohydrate and lipid exchange in the muscle, blood and liver of animal models were determined following a 15-day physical load course. In doing so, glucose, glycogen and total lipid concentrations were assessed. The KB-28 compound was administered daily at levels determined during the course of regular physical load normalized metabolic processes in rats. The results were then compared to a control which received intraperitoneally the equivolume 0.9% sodium chloride solution. The phenomenon of actoprotection consisted in enhancing concentrations of glycogen in skeletal muscles and liver. Compared to the control figures, this increase was 28.8% and 25.0%, accordingly. Moreover, the course of KB-28 caused a statistically significant reduction (by 32.1%) of the total serum lipid concentration in the animals under physical load. The effect may be a sign of the ability of this substance to utilize active lipolysis for improvement of the skeletal muscle performance. Having analyzed the results obtained, we can draw a conclusion that influencing the biochemical processes in the study models is one of the mechanisms of the KB-28 actoprotective effect.https://doi.org/10.2478/cipms-2019-0030acute lymphoblastic leukemiaphysical endurancecarbohydrate metabolismlipid metabolism2-ethylthiobenzimidazole hydrobromidesodium 2-(tetrazolo[1,5-c] quinazoline-5-ylthio)acetate |
| spellingShingle | Toziuk Olena Krasna Olga Kryvoviaz Olena Rodinkova Victoria Melnyk Andrii Ivko Tanya Voronkina Alona Hutsol Viktoriia Biochemical aspects of KB-28 compound on physically loaded study subjects Current Issues in Pharmacy and Medical Sciences acute lymphoblastic leukemia physical endurance carbohydrate metabolism lipid metabolism 2-ethylthiobenzimidazole hydrobromide sodium 2-(tetrazolo[1,5-c] quinazoline-5-ylthio)acetate |
| title | Biochemical aspects of KB-28 compound on physically loaded study subjects |
| title_full | Biochemical aspects of KB-28 compound on physically loaded study subjects |
| title_fullStr | Biochemical aspects of KB-28 compound on physically loaded study subjects |
| title_full_unstemmed | Biochemical aspects of KB-28 compound on physically loaded study subjects |
| title_short | Biochemical aspects of KB-28 compound on physically loaded study subjects |
| title_sort | biochemical aspects of kb 28 compound on physically loaded study subjects |
| topic | acute lymphoblastic leukemia physical endurance carbohydrate metabolism lipid metabolism 2-ethylthiobenzimidazole hydrobromide sodium 2-(tetrazolo[1,5-c] quinazoline-5-ylthio)acetate |
| url | https://doi.org/10.2478/cipms-2019-0030 |
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