Amino acids in hematologic malignancies: Current status and future perspective
In recent years, growing emphasis has been placed on amino acids and their role in hematologic malignancies. Cancer cell metabolism is altered during tumorigenesis and development to meet expanding energetic and biosynthetic demands. Amino acids not only act as energy-supplying substances, but also...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1113228/full |
| _version_ | 1827981713177837568 |
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| author | Mengyao Wang Ailin Zhao Meng Li Ting Niu |
| author_facet | Mengyao Wang Ailin Zhao Meng Li Ting Niu |
| author_sort | Mengyao Wang |
| collection | DOAJ |
| description | In recent years, growing emphasis has been placed on amino acids and their role in hematologic malignancies. Cancer cell metabolism is altered during tumorigenesis and development to meet expanding energetic and biosynthetic demands. Amino acids not only act as energy-supplying substances, but also play a vital role via regulating key signaling pathways, modulating epigenetic factors and remodeling tumor microenvironment. Targeting amino acids may be an effective therapeutic approach to address the current therapeutic challenges. Here, we provide an updated overview of mechanisms by which amino acids facilitate tumor development and therapy resistance. We also summarize novel therapies targeting amino acids, focusing on recent advances in basic research and their potential clinical implications. |
| first_indexed | 2024-04-09T22:13:24Z |
| format | Article |
| id | doaj.art-eee159775a8e4475a22c705b80ca4cfb |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-09T22:13:24Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-eee159775a8e4475a22c705b80ca4cfb2023-03-23T06:44:55ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-03-011010.3389/fnut.2023.11132281113228Amino acids in hematologic malignancies: Current status and future perspectiveMengyao WangAilin ZhaoMeng LiTing NiuIn recent years, growing emphasis has been placed on amino acids and their role in hematologic malignancies. Cancer cell metabolism is altered during tumorigenesis and development to meet expanding energetic and biosynthetic demands. Amino acids not only act as energy-supplying substances, but also play a vital role via regulating key signaling pathways, modulating epigenetic factors and remodeling tumor microenvironment. Targeting amino acids may be an effective therapeutic approach to address the current therapeutic challenges. Here, we provide an updated overview of mechanisms by which amino acids facilitate tumor development and therapy resistance. We also summarize novel therapies targeting amino acids, focusing on recent advances in basic research and their potential clinical implications.https://www.frontiersin.org/articles/10.3389/fnut.2023.1113228/fullamino acidhematologic malignancymetabolismtherapyglutaminolysisglutathione |
| spellingShingle | Mengyao Wang Ailin Zhao Meng Li Ting Niu Amino acids in hematologic malignancies: Current status and future perspective Frontiers in Nutrition amino acid hematologic malignancy metabolism therapy glutaminolysis glutathione |
| title | Amino acids in hematologic malignancies: Current status and future perspective |
| title_full | Amino acids in hematologic malignancies: Current status and future perspective |
| title_fullStr | Amino acids in hematologic malignancies: Current status and future perspective |
| title_full_unstemmed | Amino acids in hematologic malignancies: Current status and future perspective |
| title_short | Amino acids in hematologic malignancies: Current status and future perspective |
| title_sort | amino acids in hematologic malignancies current status and future perspective |
| topic | amino acid hematologic malignancy metabolism therapy glutaminolysis glutathione |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1113228/full |
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