Krüppel‐Like Factors Orchestrate Endothelial Gene Expression Through Redundant and Non‐Redundant Enhancer Networks

Krüppel‐Like Factors Orchestrate Endothelial Gene Expression Through Redundant and Non‐Redundant Enhancer Networks

Background Proper function of endothelial cells is critical for vascular integrity and organismal survival. Studies over the past 2 decades have identified 2 members of the KLF (Krüppel‐like factor) family of proteins, KLF2 and KLF4, as nodal regulators of endothelial function. Strikingly, inducible...

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Bibliographic Details
Main Authors: David R. Sweet, Roshan Padmanabhan, Xudong Liao, Himanshu R. Dashora, Xinmiao Tang, Lalitha Nayak, Rajan Jain, Sarah De Val, Vinesh Vinayachandran, Mukesh K. Jain
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
27 chromatin
endothelial cell
enhancer
Kruppel‐like factor
promoter
transcription
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.024303

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