Tailored Treatment of Colorectal Cancer: Surgical, Molecular, and Genetic Considerations
Colorectal cancer (CRC) is a complex cancer disease, and approximately 40% of the surgically cured patients will experience cancer recurrence within 5 years. During recent years, research has shown that CRC treatment should be tailored to the individual patient due to the wide variety of risk factor...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-02-01
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| Series: | Clinical Medicine Insights: Oncology |
| Online Access: | https://doi.org/10.1177/1179554917690766 |
| _version_ | 1828834649571328000 |
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| author | Knut Magne Augestad Marianne A Merok Dejan Ignatovic |
| author_facet | Knut Magne Augestad Marianne A Merok Dejan Ignatovic |
| author_sort | Knut Magne Augestad |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a complex cancer disease, and approximately 40% of the surgically cured patients will experience cancer recurrence within 5 years. During recent years, research has shown that CRC treatment should be tailored to the individual patient due to the wide variety of risk factors, genetic factors, and surgical complexity. In this review, we provide an overview of the considerations that are needed to provide an individualized, patient-tailored treatment. We emphasize the need to assess the predictors of CRC, and we summarize the latest research on CRC genetics and immunotherapy. Finally, we provide a summary of the significant variations in the colon and rectal anatomy that is important to consider in an individualized surgical approach. For the individual patient with CRC, a tailored treatment approach is needed in the preoperative, operative, and postoperative phase. |
| first_indexed | 2024-12-12T17:43:38Z |
| format | Article |
| id | doaj.art-eee88b1ac57e4828b819c4f24a509bc4 |
| institution | Directory Open Access Journal |
| issn | 1179-5549 |
| language | English |
| last_indexed | 2024-12-12T17:43:38Z |
| publishDate | 2017-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Oncology |
| spelling | doaj.art-eee88b1ac57e4828b819c4f24a509bc42022-12-22T00:16:59ZengSAGE PublishingClinical Medicine Insights: Oncology1179-55492017-02-011110.1177/117955491769076610.1177_1179554917690766Tailored Treatment of Colorectal Cancer: Surgical, Molecular, and Genetic ConsiderationsKnut Magne Augestad0Marianne A Merok1Dejan Ignatovic2Department of Gastrointestinal Surgery, Akershus University Hospital, Oslo, NorwayDepartment of Gastrointestinal Surgery, Akershus University Hospital, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, NorwayColorectal cancer (CRC) is a complex cancer disease, and approximately 40% of the surgically cured patients will experience cancer recurrence within 5 years. During recent years, research has shown that CRC treatment should be tailored to the individual patient due to the wide variety of risk factors, genetic factors, and surgical complexity. In this review, we provide an overview of the considerations that are needed to provide an individualized, patient-tailored treatment. We emphasize the need to assess the predictors of CRC, and we summarize the latest research on CRC genetics and immunotherapy. Finally, we provide a summary of the significant variations in the colon and rectal anatomy that is important to consider in an individualized surgical approach. For the individual patient with CRC, a tailored treatment approach is needed in the preoperative, operative, and postoperative phase.https://doi.org/10.1177/1179554917690766 |
| spellingShingle | Knut Magne Augestad Marianne A Merok Dejan Ignatovic Tailored Treatment of Colorectal Cancer: Surgical, Molecular, and Genetic Considerations Clinical Medicine Insights: Oncology |
| title | Tailored Treatment of Colorectal Cancer: Surgical, Molecular, and Genetic Considerations |
| title_full | Tailored Treatment of Colorectal Cancer: Surgical, Molecular, and Genetic Considerations |
| title_fullStr | Tailored Treatment of Colorectal Cancer: Surgical, Molecular, and Genetic Considerations |
| title_full_unstemmed | Tailored Treatment of Colorectal Cancer: Surgical, Molecular, and Genetic Considerations |
| title_short | Tailored Treatment of Colorectal Cancer: Surgical, Molecular, and Genetic Considerations |
| title_sort | tailored treatment of colorectal cancer surgical molecular and genetic considerations |
| url | https://doi.org/10.1177/1179554917690766 |
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