Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infants
Abstract Objective To evaluate the association between hematological parameters at birth and the risk of moderate-severe bronchopulmonary dysplasia (BPD) in a cohort of extremely preterm infants. Methods This is a retrospective study of all extremely premature infants admitted to the neonatal intens...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-04-01
|
| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12887-019-1515-6 |
| _version_ | 1819017341887840256 |
|---|---|
| author | Xueyu Chen Huitao Li Xiaomei Qiu Chuanzhong Yang Frans J. Walther |
| author_facet | Xueyu Chen Huitao Li Xiaomei Qiu Chuanzhong Yang Frans J. Walther |
| author_sort | Xueyu Chen |
| collection | DOAJ |
| description | Abstract Objective To evaluate the association between hematological parameters at birth and the risk of moderate-severe bronchopulmonary dysplasia (BPD) in a cohort of extremely preterm infants. Methods This is a retrospective study of all extremely premature infants admitted to the neonatal intensive care unit, Shenzhen Maternity and Child Healthcare Hospital from January 2016 to May 2018. Extremely prematurity was defined as a delivery at a gestational age ≤ 28 weeks or a birth weight ≤ 1000 g. BPD was diagnosed if oxygen exposure exceeded 28 days and the severity was decided at 36 weeks PMA or discharge. Multivariable analysis was performed to assess the independence of the association between hematological parameters at birth and risk of moderate or severe BPD. Results A total of 115 extremely premature infants were analyzed in this study. The median platelet count, neutrophil and monocyte count at birth were significantly higher in infants with moderate-severe BPD compared to infants without BPD (228 vs 194*109/l, P = 0.004; 5.0 vs 2.95*109/l, P = 0.023; 0.88 vs 0.63*109/l, P = 0.026, respectively) whereas the mean platelet volume was significantly lower in infants with moderate-severe BPD than those without BPD (9.1 vs 9.4 fl, P = 0.002). After adjusting for covariates, the risk of moderate-severe BPD was independently associated with platelet count≥207*109/l (odds ratio 3.794, 95% confidence interval: 1.742–8.266, P = 0.001). Conclusion Our findings suggest that hematologic parameters at birth are different in extremely preterm infants who will develop moderate-severe BPD. A higher platelet count at birth may increase the risk of moderate-severe BPD after extremely premature birth. |
| first_indexed | 2024-12-21T03:02:00Z |
| format | Article |
| id | doaj.art-eee98a7a3ce147f18ae6519c93232cb3 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-21T03:02:00Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-eee98a7a3ce147f18ae6519c93232cb32022-12-21T19:18:10ZengBMCBMC Pediatrics1471-24312019-04-011911710.1186/s12887-019-1515-6Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infantsXueyu Chen0Huitao Li1Xiaomei Qiu2Chuanzhong Yang3Frans J. Walther4Department of Neonatology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical UniversityDepartment of Neonatology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical UniversityDepartment of Neonatology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical UniversityDepartment of Neonatology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical UniversityDepartment of Pediatrics, David Geffen School of Medicine, University of California Los AngelesAbstract Objective To evaluate the association between hematological parameters at birth and the risk of moderate-severe bronchopulmonary dysplasia (BPD) in a cohort of extremely preterm infants. Methods This is a retrospective study of all extremely premature infants admitted to the neonatal intensive care unit, Shenzhen Maternity and Child Healthcare Hospital from January 2016 to May 2018. Extremely prematurity was defined as a delivery at a gestational age ≤ 28 weeks or a birth weight ≤ 1000 g. BPD was diagnosed if oxygen exposure exceeded 28 days and the severity was decided at 36 weeks PMA or discharge. Multivariable analysis was performed to assess the independence of the association between hematological parameters at birth and risk of moderate or severe BPD. Results A total of 115 extremely premature infants were analyzed in this study. The median platelet count, neutrophil and monocyte count at birth were significantly higher in infants with moderate-severe BPD compared to infants without BPD (228 vs 194*109/l, P = 0.004; 5.0 vs 2.95*109/l, P = 0.023; 0.88 vs 0.63*109/l, P = 0.026, respectively) whereas the mean platelet volume was significantly lower in infants with moderate-severe BPD than those without BPD (9.1 vs 9.4 fl, P = 0.002). After adjusting for covariates, the risk of moderate-severe BPD was independently associated with platelet count≥207*109/l (odds ratio 3.794, 95% confidence interval: 1.742–8.266, P = 0.001). Conclusion Our findings suggest that hematologic parameters at birth are different in extremely preterm infants who will develop moderate-severe BPD. A higher platelet count at birth may increase the risk of moderate-severe BPD after extremely premature birth.http://link.springer.com/article/10.1186/s12887-019-1515-6Extremely prematurityBronchopulmonary dysplasiaHematologyPlatelets |
| spellingShingle | Xueyu Chen Huitao Li Xiaomei Qiu Chuanzhong Yang Frans J. Walther Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infants BMC Pediatrics Extremely prematurity Bronchopulmonary dysplasia Hematology Platelets |
| title | Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infants |
| title_full | Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infants |
| title_fullStr | Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infants |
| title_full_unstemmed | Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infants |
| title_short | Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infants |
| title_sort | neonatal hematological parameters and the risk of moderate severe bronchopulmonary dysplasia in extremely premature infants |
| topic | Extremely prematurity Bronchopulmonary dysplasia Hematology Platelets |
| url | http://link.springer.com/article/10.1186/s12887-019-1515-6 |
| work_keys_str_mv | AT xueyuchen neonatalhematologicalparametersandtheriskofmoderateseverebronchopulmonarydysplasiainextremelyprematureinfants AT huitaoli neonatalhematologicalparametersandtheriskofmoderateseverebronchopulmonarydysplasiainextremelyprematureinfants AT xiaomeiqiu neonatalhematologicalparametersandtheriskofmoderateseverebronchopulmonarydysplasiainextremelyprematureinfants AT chuanzhongyang neonatalhematologicalparametersandtheriskofmoderateseverebronchopulmonarydysplasiainextremelyprematureinfants AT fransjwalther neonatalhematologicalparametersandtheriskofmoderateseverebronchopulmonarydysplasiainextremelyprematureinfants |