Assessment of serum vitamin D level in children with type 1 diabetes mellitus: A cross-sectional study
Objectives: To estimate vitamin D levels in children with type 1 diabetes, and to evaluate its role in the pathogenesis and progress of the disease. Method: The cross-sectional study was conducted at the Paediatric Department of Kafrelsheikh University Hospital, Egypt, from November 2019 to August...
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Pakistan Medical Association
2023-05-01
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| Series: | Journal of the Pakistan Medical Association |
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| Online Access: | https://ojs.jpma.org.pk/index.php/public_html/article/view/9888 |
| _version_ | 1797812137465217024 |
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| author | Asmaa Saeed Bayan Nahla Abd El-Aziz Nosair Abeer Mohamed Salamah |
| author_facet | Asmaa Saeed Bayan Nahla Abd El-Aziz Nosair Abeer Mohamed Salamah |
| author_sort | Asmaa Saeed Bayan |
| collection | DOAJ |
| description |
Objectives: To estimate vitamin D levels in children with type 1 diabetes, and to evaluate its role in the pathogenesis and progress of the disease.
Method: The cross-sectional study was conducted at the Paediatric Department of Kafrelsheikh University Hospital, Egypt, from November 2019 to August 2021, and comprised children of either gender aged 3-18 years who were either inpatients or visiting the paediatric outpatient clinic. The subjects were enrolled into 3 groups. Those with newly diagnosed type 1 diabetes were in group A, those with established type 1 diabetes were in group B, and healthy children matched for age and gender and randomly selected were in the control group C. Glycated haemoglobin, serum fasting C-peptide, and serum vitamin D levels were evaluated using quantitative colorimetric determination,
an automated analyser, and enzyme-linked immunosorbent assay, respectively. Data was analysed using SPSS 25.
Results: Of the 80 subjects, 30(37.5%) were in group A; 17(56.7%) boys and 13(43.3%) girls with mean age 7.77±2.95 years. In group B, there were 30(37.5%) subjects; 14(46.7%) boys and 16(53.3%) girls with mean age 9.6±3.62 years. There were 20(25%) subjects in group C; 10(50%) boys and as many girls with mean age 8.38±2.68 years (p>0.05). Glycated haemoglobin, serum fasting C-peptide and serum vitamin D was significantly different between the control group and the treatment groups (p<0.05). Between the treatment groups, group B had better markers than group A (p<0.05).
Conclusion: Serum vitamin D deficiency may play a role in the pathogenesis and insulin sensitivity in cases of type 1 diabetes.
Keywords: Diabetes mellitus, C-Peptide, Glycated haemoglobin, Colorimetry
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| first_indexed | 2024-03-13T07:33:42Z |
| format | Article |
| id | doaj.art-eee9990807e849158a92c19122e9ee2c |
| institution | Directory Open Access Journal |
| issn | 0030-9982 |
| language | English |
| last_indexed | 2024-03-13T07:33:42Z |
| publishDate | 2023-05-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj.art-eee9990807e849158a92c19122e9ee2c2023-06-04T04:23:12ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822023-05-0173410.47391/JPMA.EGY-S4-61Assessment of serum vitamin D level in children with type 1 diabetes mellitus: A cross-sectional studyAsmaa Saeed Bayan0Nahla Abd El-Aziz Nosair1Abeer Mohamed Salamah2Department of Clinical Pathology, Kafrelsheikh University, Egypt.Department of Clinical Pathology, Kafrelsheikh University, Egypt.Department of Paediatric, Kafrelsheikh University, Egypt. Objectives: To estimate vitamin D levels in children with type 1 diabetes, and to evaluate its role in the pathogenesis and progress of the disease. Method: The cross-sectional study was conducted at the Paediatric Department of Kafrelsheikh University Hospital, Egypt, from November 2019 to August 2021, and comprised children of either gender aged 3-18 years who were either inpatients or visiting the paediatric outpatient clinic. The subjects were enrolled into 3 groups. Those with newly diagnosed type 1 diabetes were in group A, those with established type 1 diabetes were in group B, and healthy children matched for age and gender and randomly selected were in the control group C. Glycated haemoglobin, serum fasting C-peptide, and serum vitamin D levels were evaluated using quantitative colorimetric determination, an automated analyser, and enzyme-linked immunosorbent assay, respectively. Data was analysed using SPSS 25. Results: Of the 80 subjects, 30(37.5%) were in group A; 17(56.7%) boys and 13(43.3%) girls with mean age 7.77±2.95 years. In group B, there were 30(37.5%) subjects; 14(46.7%) boys and 16(53.3%) girls with mean age 9.6±3.62 years. There were 20(25%) subjects in group C; 10(50%) boys and as many girls with mean age 8.38±2.68 years (p>0.05). Glycated haemoglobin, serum fasting C-peptide and serum vitamin D was significantly different between the control group and the treatment groups (p<0.05). Between the treatment groups, group B had better markers than group A (p<0.05). Conclusion: Serum vitamin D deficiency may play a role in the pathogenesis and insulin sensitivity in cases of type 1 diabetes. Keywords: Diabetes mellitus, C-Peptide, Glycated haemoglobin, Colorimetry https://ojs.jpma.org.pk/index.php/public_html/article/view/9888Diabetes mellitusC-PeptideGlycated haemoglobinColorimetry |
| spellingShingle | Asmaa Saeed Bayan Nahla Abd El-Aziz Nosair Abeer Mohamed Salamah Assessment of serum vitamin D level in children with type 1 diabetes mellitus: A cross-sectional study Journal of the Pakistan Medical Association Diabetes mellitus C-Peptide Glycated haemoglobin Colorimetry |
| title | Assessment of serum vitamin D level in children with type 1 diabetes mellitus: A cross-sectional study |
| title_full | Assessment of serum vitamin D level in children with type 1 diabetes mellitus: A cross-sectional study |
| title_fullStr | Assessment of serum vitamin D level in children with type 1 diabetes mellitus: A cross-sectional study |
| title_full_unstemmed | Assessment of serum vitamin D level in children with type 1 diabetes mellitus: A cross-sectional study |
| title_short | Assessment of serum vitamin D level in children with type 1 diabetes mellitus: A cross-sectional study |
| title_sort | assessment of serum vitamin d level in children with type 1 diabetes mellitus a cross sectional study |
| topic | Diabetes mellitus C-Peptide Glycated haemoglobin Colorimetry |
| url | https://ojs.jpma.org.pk/index.php/public_html/article/view/9888 |
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