Alteration of Cortical Volume and Thickness in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Myalgic Encephalomyelitis/Chronic fatigue syndrome (ME/CFS) patients suffer from neurocognitive impairment. In this study, we investigated cortical volumetric and thickness changes in ME/CFS patients and healthy controls (HC). We estimated mean surface-based cortical volume and thickness from 18 ME/...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.848730/full |
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| author | Kiran Thapaliya Kiran Thapaliya Sonya Marshall-Gradisnik Donald Staines Jiasheng Su Leighton Barnden |
| author_facet | Kiran Thapaliya Kiran Thapaliya Sonya Marshall-Gradisnik Donald Staines Jiasheng Su Leighton Barnden |
| author_sort | Kiran Thapaliya |
| collection | DOAJ |
| description | Myalgic Encephalomyelitis/Chronic fatigue syndrome (ME/CFS) patients suffer from neurocognitive impairment. In this study, we investigated cortical volumetric and thickness changes in ME/CFS patients and healthy controls (HC). We estimated mean surface-based cortical volume and thickness from 18 ME/CFS patients who met International Consensus Criteria (ICC) and 26 HC using FreeSurfer. Vertex-wise analysis showed significant reductions in the caudal middle frontal gyrus (p = 0.0016) and precuneus (p = 0.013) thickness in ME/CFS patients compared with HC. Region based analysis of sub-cortical volumes found that amygdala volume (p = 0.002) was significantly higher in ME/CFS patients compared with HC. We also performed interaction-with-group regressions with clinical measures to test for cortical volume and thickness correlations in ME/CFS with opposite slopes to HC (abnormal). ME/CFS cortical volume and thickness regressions with fatigue, heart-rate variability, heart rate, sleep disturbance score, respiratory rate, and cognitive performance were abnormal. Our study demonstrated different cortical volume and thickness in ME/CFS patients and showed abnormal cortical volume and thickness regressions with key symptoms of ME/CFS patients. |
| first_indexed | 2024-04-13T13:07:59Z |
| format | Article |
| id | doaj.art-eee9f8cd9ad54055bea2f7de54b9a756 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T13:07:59Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-eee9f8cd9ad54055bea2f7de54b9a7562022-12-22T02:45:42ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-04-011610.3389/fnins.2022.848730848730Alteration of Cortical Volume and Thickness in Myalgic Encephalomyelitis/Chronic Fatigue SyndromeKiran Thapaliya0Kiran Thapaliya1Sonya Marshall-Gradisnik2Donald Staines3Jiasheng Su4Leighton Barnden5National Center for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, AustraliaCenter for Advanced Imaging, The University of Queensland, Brisbane, QLD, AustraliaNational Center for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, AustraliaNational Center for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, AustraliaNational Center for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, AustraliaNational Center for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, AustraliaMyalgic Encephalomyelitis/Chronic fatigue syndrome (ME/CFS) patients suffer from neurocognitive impairment. In this study, we investigated cortical volumetric and thickness changes in ME/CFS patients and healthy controls (HC). We estimated mean surface-based cortical volume and thickness from 18 ME/CFS patients who met International Consensus Criteria (ICC) and 26 HC using FreeSurfer. Vertex-wise analysis showed significant reductions in the caudal middle frontal gyrus (p = 0.0016) and precuneus (p = 0.013) thickness in ME/CFS patients compared with HC. Region based analysis of sub-cortical volumes found that amygdala volume (p = 0.002) was significantly higher in ME/CFS patients compared with HC. We also performed interaction-with-group regressions with clinical measures to test for cortical volume and thickness correlations in ME/CFS with opposite slopes to HC (abnormal). ME/CFS cortical volume and thickness regressions with fatigue, heart-rate variability, heart rate, sleep disturbance score, respiratory rate, and cognitive performance were abnormal. Our study demonstrated different cortical volume and thickness in ME/CFS patients and showed abnormal cortical volume and thickness regressions with key symptoms of ME/CFS patients.https://www.frontiersin.org/articles/10.3389/fnins.2022.848730/fullcortexmyalgic encephalomyelitis/chronic fatigue syndromeInternational Consensus Criteriasub-cortical regionsvolume and thicknessclinical measures |
| spellingShingle | Kiran Thapaliya Kiran Thapaliya Sonya Marshall-Gradisnik Donald Staines Jiasheng Su Leighton Barnden Alteration of Cortical Volume and Thickness in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Frontiers in Neuroscience cortex myalgic encephalomyelitis/chronic fatigue syndrome International Consensus Criteria sub-cortical regions volume and thickness clinical measures |
| title | Alteration of Cortical Volume and Thickness in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
| title_full | Alteration of Cortical Volume and Thickness in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
| title_fullStr | Alteration of Cortical Volume and Thickness in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
| title_full_unstemmed | Alteration of Cortical Volume and Thickness in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
| title_short | Alteration of Cortical Volume and Thickness in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
| title_sort | alteration of cortical volume and thickness in myalgic encephalomyelitis chronic fatigue syndrome |
| topic | cortex myalgic encephalomyelitis/chronic fatigue syndrome International Consensus Criteria sub-cortical regions volume and thickness clinical measures |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.848730/full |
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