Clinicopathologic characteristics of early-onset breast cancer: a comparative analysis of cases from across Ghana
Abstract Background Breast cancer is the commonest cancer diagnosed globally and the second leading cause of cancer-related mortality among women younger than 40 years. This study comparatively reviewed the demographic, pathologic and molecular features of Early-Onset Breast Cancer (EOBC) reported i...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Women's Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12905-022-02142-w |
| _version_ | 1828069455503032320 |
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| author | Patrick Kafui Akakpo Emmanuel Gustav Imbeah Lawrence Edusei Simon Naporo Kofi Ulzen-Appiah Joe Nat Clegg-Lamptey Florence Dedey Josephine Nsaful Nelson Affram Beatrice Wiafe Samuel Mensah Michael Nortey Mohammed Sheriff Forster Amponsah-Manu Kwabena Agbedinu Evelyn Mawunyo Jiagge |
| author_facet | Patrick Kafui Akakpo Emmanuel Gustav Imbeah Lawrence Edusei Simon Naporo Kofi Ulzen-Appiah Joe Nat Clegg-Lamptey Florence Dedey Josephine Nsaful Nelson Affram Beatrice Wiafe Samuel Mensah Michael Nortey Mohammed Sheriff Forster Amponsah-Manu Kwabena Agbedinu Evelyn Mawunyo Jiagge |
| author_sort | Patrick Kafui Akakpo |
| collection | DOAJ |
| description | Abstract Background Breast cancer is the commonest cancer diagnosed globally and the second leading cause of cancer-related mortality among women younger than 40 years. This study comparatively reviewed the demographic, pathologic and molecular features of Early-Onset Breast Cancer (EOBC) reported in Ghana in relation to Late Onset Breast Cancer (LOBC). Methods A descriptive, cross-sectional design was used, with purposive sampling of retrospective histopathology data from 2019 to 2021. Reports of core or incision biopsy, Wide Local Excision or Mastectomy with or without axillary lymph node dissection specimen and matched immunohistochemistry reports were merged into a single file and analysed with SPSS v. 20.0. Descriptive statistics of frequencies and percentages were used to describe categorical variables. Cross-tabulation and chi-square test was done at a 95% confidence interval with significance established at p < 0.05. Results A total of 2418 cases were included in the study with 20.2% (488 cases) being EOBCs and 79.8% (1930 cases) being LOBCs. The median age at diagnosis was 34.66 (IQR: 5.55) in the EOBC group (< 40 years) and 54.29 (IQR: 16.86) in the LOBC group (≥ 40 years). Invasive carcinoma—No Special Type was the commonest tumour type with grade III tumours being the commonest in both categories of patients. Perineural invasion was the only statistically significant pathologic parameter with age. EOBC was associated with higher DCIS component (24.8% vs 21.6%), lower hormone-receptor-positive status (52.30% vs 55.70%), higher proliferation index (Ki-67 > 20: 82.40% vs 80.30%) and a higher number of involved lymph nodes (13.80% vs 9.00%). Triple-Negative Breast cancer (26.40% vs 24.30%) was the most predominant molecular subtype of EOBC. Conclusion EOBCs in our setting are generally more aggressive with poorer prognostic histopathological and molecular features when compared with LOBCs. A larger study is recommended to identify the association between relevant pathological features and early onset breast cancer in Ghana. Again, further molecular and genetic studies to understand the molecular genetic drivers of the general poorer pathological features of EOBCs and its relation to patient outcome in our setting is needed. |
| first_indexed | 2024-04-11T00:21:20Z |
| format | Article |
| id | doaj.art-eeec7c63e72041429b29e0a64997f352 |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-04-11T00:21:20Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-eeec7c63e72041429b29e0a64997f3522023-01-08T12:19:41ZengBMCBMC Women's Health1472-68742023-01-012311710.1186/s12905-022-02142-wClinicopathologic characteristics of early-onset breast cancer: a comparative analysis of cases from across GhanaPatrick Kafui Akakpo0Emmanuel Gustav Imbeah1Lawrence Edusei2Simon Naporo3Kofi Ulzen-Appiah4Joe Nat Clegg-Lamptey5Florence Dedey6Josephine Nsaful7Nelson Affram8Beatrice Wiafe9Samuel Mensah10Michael Nortey11Mohammed Sheriff12Forster Amponsah-Manu13Kwabena Agbedinu14Evelyn Mawunyo Jiagge15Department of Pathology, University of Cape Coast/Cape Coast Teaching HospitalACT Pathology ConsultPathologists Without Borders LtdPathologists Without Borders LtdDepartment of Pathology, University of Cape Coast/Cape Coast Teaching HospitalDepartment of Surgery, University of Ghana Medical School/Korle Bu Teaching Hospital AccraDepartment of Surgery, University of Ghana Medical School/Korle Bu Teaching Hospital AccraDepartment of Surgery, University of Ghana Medical School/Korle Bu Teaching Hospital AccraDepartment of Surgery, Ho Teaching HospitalPeace and Love HospitalDepartment of Surgery, School of Medicine and Dentistry, Kwame Nkrumah University of Science and TechnologyDepartment of Surgery, University of Cape Coast / Cape Coast Teaching HospitalDepartment of Surgery, Tamale Teaching HospitalDepartment of Surgery, Eastern Regional HospitalDepartment of Surgery, Komfo-Anokye Teaching HospitalHenry Ford Cancer Institute/Henry Ford Health SystemAbstract Background Breast cancer is the commonest cancer diagnosed globally and the second leading cause of cancer-related mortality among women younger than 40 years. This study comparatively reviewed the demographic, pathologic and molecular features of Early-Onset Breast Cancer (EOBC) reported in Ghana in relation to Late Onset Breast Cancer (LOBC). Methods A descriptive, cross-sectional design was used, with purposive sampling of retrospective histopathology data from 2019 to 2021. Reports of core or incision biopsy, Wide Local Excision or Mastectomy with or without axillary lymph node dissection specimen and matched immunohistochemistry reports were merged into a single file and analysed with SPSS v. 20.0. Descriptive statistics of frequencies and percentages were used to describe categorical variables. Cross-tabulation and chi-square test was done at a 95% confidence interval with significance established at p < 0.05. Results A total of 2418 cases were included in the study with 20.2% (488 cases) being EOBCs and 79.8% (1930 cases) being LOBCs. The median age at diagnosis was 34.66 (IQR: 5.55) in the EOBC group (< 40 years) and 54.29 (IQR: 16.86) in the LOBC group (≥ 40 years). Invasive carcinoma—No Special Type was the commonest tumour type with grade III tumours being the commonest in both categories of patients. Perineural invasion was the only statistically significant pathologic parameter with age. EOBC was associated with higher DCIS component (24.8% vs 21.6%), lower hormone-receptor-positive status (52.30% vs 55.70%), higher proliferation index (Ki-67 > 20: 82.40% vs 80.30%) and a higher number of involved lymph nodes (13.80% vs 9.00%). Triple-Negative Breast cancer (26.40% vs 24.30%) was the most predominant molecular subtype of EOBC. Conclusion EOBCs in our setting are generally more aggressive with poorer prognostic histopathological and molecular features when compared with LOBCs. A larger study is recommended to identify the association between relevant pathological features and early onset breast cancer in Ghana. Again, further molecular and genetic studies to understand the molecular genetic drivers of the general poorer pathological features of EOBCs and its relation to patient outcome in our setting is needed.https://doi.org/10.1186/s12905-022-02142-wBreast cancerEarly-onsetPathologyCharacteristicsPrognosisGhana |
| spellingShingle | Patrick Kafui Akakpo Emmanuel Gustav Imbeah Lawrence Edusei Simon Naporo Kofi Ulzen-Appiah Joe Nat Clegg-Lamptey Florence Dedey Josephine Nsaful Nelson Affram Beatrice Wiafe Samuel Mensah Michael Nortey Mohammed Sheriff Forster Amponsah-Manu Kwabena Agbedinu Evelyn Mawunyo Jiagge Clinicopathologic characteristics of early-onset breast cancer: a comparative analysis of cases from across Ghana BMC Women's Health Breast cancer Early-onset Pathology Characteristics Prognosis Ghana |
| title | Clinicopathologic characteristics of early-onset breast cancer: a comparative analysis of cases from across Ghana |
| title_full | Clinicopathologic characteristics of early-onset breast cancer: a comparative analysis of cases from across Ghana |
| title_fullStr | Clinicopathologic characteristics of early-onset breast cancer: a comparative analysis of cases from across Ghana |
| title_full_unstemmed | Clinicopathologic characteristics of early-onset breast cancer: a comparative analysis of cases from across Ghana |
| title_short | Clinicopathologic characteristics of early-onset breast cancer: a comparative analysis of cases from across Ghana |
| title_sort | clinicopathologic characteristics of early onset breast cancer a comparative analysis of cases from across ghana |
| topic | Breast cancer Early-onset Pathology Characteristics Prognosis Ghana |
| url | https://doi.org/10.1186/s12905-022-02142-w |
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