Correlation analysis of vaginal microecology and different types of human papillomavirus infection: a study conducted at a hospital in northwest China
BackgroundVaginal microecology has a definite influence on human papillomavirus (HPV) infection and clearance, but the specific correlation is still controversial. This research aimed to investigate the differences in the vaginal microenvironment of different types of HPV infection and also provide...
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1138507/full |
| _version_ | 1797814377734209536 |
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| author | Fang Feng Yue-min Hou Yan Zhang Lu-yuan Wang Pei-pei Li Ying Guo Rui-fang An |
| author_facet | Fang Feng Yue-min Hou Yan Zhang Lu-yuan Wang Pei-pei Li Ying Guo Rui-fang An |
| author_sort | Fang Feng |
| collection | DOAJ |
| description | BackgroundVaginal microecology has a definite influence on human papillomavirus (HPV) infection and clearance, but the specific correlation is still controversial. This research aimed to investigate the differences in the vaginal microenvironment of different types of HPV infection and also provide data supporting clinical diagnosis and treatment.MethodsAccording to strict inclusion and exclusion criteria, the case data of 2,358 female patients who underwent vaginal microecology and HPV-DNA tests at the same time in the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Xi'an Jiaotong University from May 2021 to March 2022 were retrospectively analyzed. The population was divided into two groups: an HPV-positive group and an HPV-negative group. HPV-positive patients were further classified into HPV16/18-positive group and HPV other subtypes positive group. The vaginal microecology of HPV-infected patients was analyzed using the chi-square test, Fisher's exact test, and logistic regression.ResultsAmong the 2,358 female patients, the HPV infection rate was 20.27% (478/2,358), of which the HPV16/18 infection rate was 25.73% (123/478), and the HPV other subtypes infection rate was 74.27% (355/478). The difference in HPV infection rates between the age groups was statistically significant (P < 0.01). The prevalence of mixed vaginitis was 14.37% (339/2,358), with bacterial vaginosis (BV) paired with aerobic vaginitis (AV) accounting for the majority (66.37%). The difference in HPV infection rates among mixed vaginitis was not statistically significant (P > 0.05). The prevalence of single vaginitis was 24.22% (571/2,358), with the most frequent being vulvovaginal Candidiasis (VVC; 47.29%, 270/571), and there was a significant difference in HPV infection rates among single vaginitis (P < 0.001). Patients with BV had a higher risk of being positive for HPV16/18 (OR: 1.815, 95% CI: 1.050–3.139) and other subtypes (OR: 1.830, 95% CI: 1.254–2.669). Patients with Trichomoniasis were at higher odds of other HPV subtype infections (OR: 1.857, 95% CI: 1.004–3.437). On the contrary, patients with VVC had lower odds of becoming infected with other HPV subtypes (OR: 0.562, 95% CI: 0.380–0.831).ConclusionThere were disparities in HPV infection among different age groups; therefore, we should pay attention to the prevention and treatment of susceptible individuals. BV and Trichomoniasis are linked to HPV infection; hence, restoring the balance of vaginal microecology could assist in the prevention of HPV infection. As a protective factor for other HPV subtype infections, VVC may provide new insights into the development of immunotherapeutic therapies. |
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| spelling | doaj.art-eeef2961a7334273a1a1a1ddfd11ae892023-06-01T04:36:22ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-06-011010.3389/fmed.2023.11385071138507Correlation analysis of vaginal microecology and different types of human papillomavirus infection: a study conducted at a hospital in northwest ChinaFang Feng0Yue-min Hou1Yan Zhang2Lu-yuan Wang3Pei-pei Li4Ying Guo5Rui-fang An6Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinaBackgroundVaginal microecology has a definite influence on human papillomavirus (HPV) infection and clearance, but the specific correlation is still controversial. This research aimed to investigate the differences in the vaginal microenvironment of different types of HPV infection and also provide data supporting clinical diagnosis and treatment.MethodsAccording to strict inclusion and exclusion criteria, the case data of 2,358 female patients who underwent vaginal microecology and HPV-DNA tests at the same time in the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Xi'an Jiaotong University from May 2021 to March 2022 were retrospectively analyzed. The population was divided into two groups: an HPV-positive group and an HPV-negative group. HPV-positive patients were further classified into HPV16/18-positive group and HPV other subtypes positive group. The vaginal microecology of HPV-infected patients was analyzed using the chi-square test, Fisher's exact test, and logistic regression.ResultsAmong the 2,358 female patients, the HPV infection rate was 20.27% (478/2,358), of which the HPV16/18 infection rate was 25.73% (123/478), and the HPV other subtypes infection rate was 74.27% (355/478). The difference in HPV infection rates between the age groups was statistically significant (P < 0.01). The prevalence of mixed vaginitis was 14.37% (339/2,358), with bacterial vaginosis (BV) paired with aerobic vaginitis (AV) accounting for the majority (66.37%). The difference in HPV infection rates among mixed vaginitis was not statistically significant (P > 0.05). The prevalence of single vaginitis was 24.22% (571/2,358), with the most frequent being vulvovaginal Candidiasis (VVC; 47.29%, 270/571), and there was a significant difference in HPV infection rates among single vaginitis (P < 0.001). Patients with BV had a higher risk of being positive for HPV16/18 (OR: 1.815, 95% CI: 1.050–3.139) and other subtypes (OR: 1.830, 95% CI: 1.254–2.669). Patients with Trichomoniasis were at higher odds of other HPV subtype infections (OR: 1.857, 95% CI: 1.004–3.437). On the contrary, patients with VVC had lower odds of becoming infected with other HPV subtypes (OR: 0.562, 95% CI: 0.380–0.831).ConclusionThere were disparities in HPV infection among different age groups; therefore, we should pay attention to the prevention and treatment of susceptible individuals. BV and Trichomoniasis are linked to HPV infection; hence, restoring the balance of vaginal microecology could assist in the prevention of HPV infection. As a protective factor for other HPV subtype infections, VVC may provide new insights into the development of immunotherapeutic therapies.https://www.frontiersin.org/articles/10.3389/fmed.2023.1138507/fullvaginal microecologyhuman papillomavirus (HPV)mixed vaginitisbacterial vaginosisvulvovaginal candidiasis |
| spellingShingle | Fang Feng Yue-min Hou Yan Zhang Lu-yuan Wang Pei-pei Li Ying Guo Rui-fang An Correlation analysis of vaginal microecology and different types of human papillomavirus infection: a study conducted at a hospital in northwest China Frontiers in Medicine vaginal microecology human papillomavirus (HPV) mixed vaginitis bacterial vaginosis vulvovaginal candidiasis |
| title | Correlation analysis of vaginal microecology and different types of human papillomavirus infection: a study conducted at a hospital in northwest China |
| title_full | Correlation analysis of vaginal microecology and different types of human papillomavirus infection: a study conducted at a hospital in northwest China |
| title_fullStr | Correlation analysis of vaginal microecology and different types of human papillomavirus infection: a study conducted at a hospital in northwest China |
| title_full_unstemmed | Correlation analysis of vaginal microecology and different types of human papillomavirus infection: a study conducted at a hospital in northwest China |
| title_short | Correlation analysis of vaginal microecology and different types of human papillomavirus infection: a study conducted at a hospital in northwest China |
| title_sort | correlation analysis of vaginal microecology and different types of human papillomavirus infection a study conducted at a hospital in northwest china |
| topic | vaginal microecology human papillomavirus (HPV) mixed vaginitis bacterial vaginosis vulvovaginal candidiasis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1138507/full |
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