Analysis of risk factors of multiorgan failure after pericardiectomy for constrictive pericarditis
Abstract Background We aimed to investigate risk factors of multiorgan failure following pericardiectomy. Methods This was a retrospective study of patients undergoing pericardiectomy between January 1994 and May 2021 at three hospitals. Results 826 patients were included in the study and divided in...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13019-022-02007-1 |
| _version_ | 1818026036410974208 |
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| author | Jing-bin Huang Zhao-ke Wen Jian-rong Yang Jun-jun Li Min Li Chang-chao Lu Da-ying Liang Cheng-xin Wei |
| author_facet | Jing-bin Huang Zhao-ke Wen Jian-rong Yang Jun-jun Li Min Li Chang-chao Lu Da-ying Liang Cheng-xin Wei |
| author_sort | Jing-bin Huang |
| collection | DOAJ |
| description | Abstract Background We aimed to investigate risk factors of multiorgan failure following pericardiectomy. Methods This was a retrospective study of patients undergoing pericardiectomy between January 1994 and May 2021 at three hospitals. Results 826 patients were included in the study and divided into two groups: group with multiorgan failure (n = 86) and group without multiorgan failure (n = 740). There were 86 patients with multiorgan failure (86/826, 10.4%). There were 66 operative deaths (66/826, 8.0%). The causes of operative deaths were multiorgan failure, including cardiogenic shock + AKI + ventricular fibrillation (13/66), cardiogenic shock + AKI (35/66), cardiogenic shock + AKI + hepatic failure + septicemia (8/66), cardiogenic shock + AKI + respiratory failure (10/66). Univariate and multivariate analyses showed the factors associated with multiorgan failure, including male (P = 0.006), time between symptoms and surgery (P < 0.001), thickness of pericardium (P < 0.001), intubation time (P < 0.001), ICU retention time (P < 0.001), hospitalized time postoperative (P < 0.001), preoperative central venous pressure (P < 0.001), postoperative central venous pressure (P < 0.001), D0 fluid balance (P < 0.001), D2 fluid balance (P < 0.001), postoperative chest drainage (P < 0.001), preoperative LVEDD(P < 0.001), postoperative LVEDD (P < 0.001), surgical duration (P < 0.001), bleeding during operation (P < 0.001), serum creatinine 24 h after surgery (P = 0.042), serum creatinine 48 h after surgery (P < 0.001), fresh-frozen plasma (P < 0.001), packed red cells (P < 0.001), blood lactate (P < 0.001). Conclusion In our study, incomplete pericardial dissection, fluid overload, delayed diagnosis and treatment are associated with multiorgan failure following pericardiectomy. |
| first_indexed | 2024-12-10T04:25:37Z |
| format | Article |
| id | doaj.art-eeefe03157f74c2389379b59a51cd59a |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-12-10T04:25:37Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-eeefe03157f74c2389379b59a51cd59a2022-12-22T02:02:18ZengBMCJournal of Cardiothoracic Surgery1749-80902022-09-011711910.1186/s13019-022-02007-1Analysis of risk factors of multiorgan failure after pericardiectomy for constrictive pericarditisJing-bin Huang0Zhao-ke Wen1Jian-rong Yang2Jun-jun Li3Min Li4Chang-chao Lu5Da-ying Liang6Cheng-xin Wei7Department of Cardiothoracic Surgery, The People’s Hospital of Guangxi Zhuang Autonomous Region, and Guangxi Academy of Medical SciencesDepartment of Cardiothoracic Surgery, The People’s Hospital of Guangxi Zhuang Autonomous Region, and Guangxi Academy of Medical SciencesDepartment of Cardiothoracic Surgery, The People’s Hospital of Guangxi Zhuang Autonomous Region, and Guangxi Academy of Medical SciencesDepartment of Cardiothoracic Surgery, The People’s Hospital of Guangxi Zhuang Autonomous Region, and Guangxi Academy of Medical SciencesDepartment of Cardiothoracic Surgery, The People’s Hospital of Guangxi Zhuang Autonomous Region, and Guangxi Academy of Medical SciencesDepartment of Cardiothoracic Surgery, The People’s Hospital of Guangxi Zhuang Autonomous Region, and Guangxi Academy of Medical SciencesDepartment of Cardiothoracic Surgery, Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineDepartment of Cardiothoracic Surgery, The People’s Hospital of Liuzhou CityAbstract Background We aimed to investigate risk factors of multiorgan failure following pericardiectomy. Methods This was a retrospective study of patients undergoing pericardiectomy between January 1994 and May 2021 at three hospitals. Results 826 patients were included in the study and divided into two groups: group with multiorgan failure (n = 86) and group without multiorgan failure (n = 740). There were 86 patients with multiorgan failure (86/826, 10.4%). There were 66 operative deaths (66/826, 8.0%). The causes of operative deaths were multiorgan failure, including cardiogenic shock + AKI + ventricular fibrillation (13/66), cardiogenic shock + AKI (35/66), cardiogenic shock + AKI + hepatic failure + septicemia (8/66), cardiogenic shock + AKI + respiratory failure (10/66). Univariate and multivariate analyses showed the factors associated with multiorgan failure, including male (P = 0.006), time between symptoms and surgery (P < 0.001), thickness of pericardium (P < 0.001), intubation time (P < 0.001), ICU retention time (P < 0.001), hospitalized time postoperative (P < 0.001), preoperative central venous pressure (P < 0.001), postoperative central venous pressure (P < 0.001), D0 fluid balance (P < 0.001), D2 fluid balance (P < 0.001), postoperative chest drainage (P < 0.001), preoperative LVEDD(P < 0.001), postoperative LVEDD (P < 0.001), surgical duration (P < 0.001), bleeding during operation (P < 0.001), serum creatinine 24 h after surgery (P = 0.042), serum creatinine 48 h after surgery (P < 0.001), fresh-frozen plasma (P < 0.001), packed red cells (P < 0.001), blood lactate (P < 0.001). Conclusion In our study, incomplete pericardial dissection, fluid overload, delayed diagnosis and treatment are associated with multiorgan failure following pericardiectomy.https://doi.org/10.1186/s13019-022-02007-1Incomplete pericardial dissectionFluid overloadmultiorgan failurePericardiectomy |
| spellingShingle | Jing-bin Huang Zhao-ke Wen Jian-rong Yang Jun-jun Li Min Li Chang-chao Lu Da-ying Liang Cheng-xin Wei Analysis of risk factors of multiorgan failure after pericardiectomy for constrictive pericarditis Journal of Cardiothoracic Surgery Incomplete pericardial dissection Fluid overload multiorgan failure Pericardiectomy |
| title | Analysis of risk factors of multiorgan failure after pericardiectomy for constrictive pericarditis |
| title_full | Analysis of risk factors of multiorgan failure after pericardiectomy for constrictive pericarditis |
| title_fullStr | Analysis of risk factors of multiorgan failure after pericardiectomy for constrictive pericarditis |
| title_full_unstemmed | Analysis of risk factors of multiorgan failure after pericardiectomy for constrictive pericarditis |
| title_short | Analysis of risk factors of multiorgan failure after pericardiectomy for constrictive pericarditis |
| title_sort | analysis of risk factors of multiorgan failure after pericardiectomy for constrictive pericarditis |
| topic | Incomplete pericardial dissection Fluid overload multiorgan failure Pericardiectomy |
| url | https://doi.org/10.1186/s13019-022-02007-1 |
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