A preliminary observation on rod cell photobiomodulation in treating diabetic macular edema
Purpose: To evaluate the safety and effectiveness of photobiomodulation (PBM) in the treatment of diabetic macular edema (DME). Methods: It was a single-center, self-controlled prospective study. The clinical records of 12 diabetic retinopathy patients (5 males and 7 females, 20 eyes in total) who w...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Advances in Ophthalmology Practice and Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667376222000282 |
| _version_ | 1818190592293732352 |
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| author | Zhiqing Chen Binbin Chen Peike Hu Haipeng Liu Dingchang Zheng |
| author_facet | Zhiqing Chen Binbin Chen Peike Hu Haipeng Liu Dingchang Zheng |
| author_sort | Zhiqing Chen |
| collection | DOAJ |
| description | Purpose: To evaluate the safety and effectiveness of photobiomodulation (PBM) in the treatment of diabetic macular edema (DME). Methods: It was a single-center, self-controlled prospective study. The clinical records of 12 diabetic retinopathy patients (5 males and 7 females, 20 eyes in total) who were treated with PBM for DME at the Second Affiliated Hospital, Zhejiang University School of Medicine, were analyzed. The mean age was 56 (26–68) years. All the participants received PBM treatment during darkness at night in no less than 5 days per week and no less than 8 h per day. In the baseline check and follow-up checks (1, 2, 6, 10, and 12 months after the start of treatment), the best-corrected visual acuity, the thickness of the retina in the macula, and the changes of the fundus lesions were observed. Wilcoxon signed rank test was used to compare the results before and after treatment. P < 0.05 was considered statistically significant. Results: No fundus complication was observed during follow-up checks. In baseline and 12-month follow-up checks, the best-corrected visual acuity was 71.75 ± 12.47 and 79.50 ± 10.85, maximal retinal thickness in macular area was 390.95 ± 77.12 μm and 354.13 ± 55.03 μm, average retinal thickness in macular area was 334.25 ± 36.45 μm and 314.31 ± 33.28 μm, foveal thickness was 287.00 ± 46.79 μm and 265.63 ± 67.14 μm. The best-corrected visual acuity, average retinal thickness in macular area in consecutive follow-up results except that in the 1st month showed significant difference compared with baseline results. There were significant difference between every follow-up result and baseline result of maximal retinal thickness in macular area (P < 0.05). All follow-up results of foveal thickness were not significantly different (P > 0.05) from the baseline result, except that in the 6th month (P = 0.049). Obvious improvement could be observed in retinal fundus fluorescein angiography images. Conclusions: PBM is a safe and effective treatment of DME, which deserves further investigation. |
| first_indexed | 2024-12-12T00:01:10Z |
| format | Article |
| id | doaj.art-eef05c29a3ed49f3b5035697b8a9d48b |
| institution | Directory Open Access Journal |
| issn | 2667-3762 |
| language | English |
| last_indexed | 2024-12-12T00:01:10Z |
| publishDate | 2022-08-01 |
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| series | Advances in Ophthalmology Practice and Research |
| spelling | doaj.art-eef05c29a3ed49f3b5035697b8a9d48b2022-12-22T00:45:14ZengElsevierAdvances in Ophthalmology Practice and Research2667-37622022-08-0122100051A preliminary observation on rod cell photobiomodulation in treating diabetic macular edemaZhiqing Chen0Binbin Chen1Peike Hu2Haipeng Liu3Dingchang Zheng4Eye Centre, The Second Affiliated Hospital of the School of Medicine, Zhejiang University, Hangzhou, China; Corresponding author. Eye Centre, The Second Affiliated Hospital of the School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, ChinaEye Centre, The Second Affiliated Hospital of the School of Medicine, Zhejiang University, Hangzhou, ChinaEye Centre, The Second Affiliated Hospital of the School of Medicine, Zhejiang University, Hangzhou, ChinaResearch Centre for Intelligent Healthcare, University of Coventry, Coventry, UKResearch Centre for Intelligent Healthcare, University of Coventry, Coventry, UKPurpose: To evaluate the safety and effectiveness of photobiomodulation (PBM) in the treatment of diabetic macular edema (DME). Methods: It was a single-center, self-controlled prospective study. The clinical records of 12 diabetic retinopathy patients (5 males and 7 females, 20 eyes in total) who were treated with PBM for DME at the Second Affiliated Hospital, Zhejiang University School of Medicine, were analyzed. The mean age was 56 (26–68) years. All the participants received PBM treatment during darkness at night in no less than 5 days per week and no less than 8 h per day. In the baseline check and follow-up checks (1, 2, 6, 10, and 12 months after the start of treatment), the best-corrected visual acuity, the thickness of the retina in the macula, and the changes of the fundus lesions were observed. Wilcoxon signed rank test was used to compare the results before and after treatment. P < 0.05 was considered statistically significant. Results: No fundus complication was observed during follow-up checks. In baseline and 12-month follow-up checks, the best-corrected visual acuity was 71.75 ± 12.47 and 79.50 ± 10.85, maximal retinal thickness in macular area was 390.95 ± 77.12 μm and 354.13 ± 55.03 μm, average retinal thickness in macular area was 334.25 ± 36.45 μm and 314.31 ± 33.28 μm, foveal thickness was 287.00 ± 46.79 μm and 265.63 ± 67.14 μm. The best-corrected visual acuity, average retinal thickness in macular area in consecutive follow-up results except that in the 1st month showed significant difference compared with baseline results. There were significant difference between every follow-up result and baseline result of maximal retinal thickness in macular area (P < 0.05). All follow-up results of foveal thickness were not significantly different (P > 0.05) from the baseline result, except that in the 6th month (P = 0.049). Obvious improvement could be observed in retinal fundus fluorescein angiography images. Conclusions: PBM is a safe and effective treatment of DME, which deserves further investigation.http://www.sciencedirect.com/science/article/pii/S2667376222000282Dark adaptationDiabetic macular edemaDiabetic retinopathyPhotobiomodulationRod cells |
| spellingShingle | Zhiqing Chen Binbin Chen Peike Hu Haipeng Liu Dingchang Zheng A preliminary observation on rod cell photobiomodulation in treating diabetic macular edema Advances in Ophthalmology Practice and Research Dark adaptation Diabetic macular edema Diabetic retinopathy Photobiomodulation Rod cells |
| title | A preliminary observation on rod cell photobiomodulation in treating diabetic macular edema |
| title_full | A preliminary observation on rod cell photobiomodulation in treating diabetic macular edema |
| title_fullStr | A preliminary observation on rod cell photobiomodulation in treating diabetic macular edema |
| title_full_unstemmed | A preliminary observation on rod cell photobiomodulation in treating diabetic macular edema |
| title_short | A preliminary observation on rod cell photobiomodulation in treating diabetic macular edema |
| title_sort | preliminary observation on rod cell photobiomodulation in treating diabetic macular edema |
| topic | Dark adaptation Diabetic macular edema Diabetic retinopathy Photobiomodulation Rod cells |
| url | http://www.sciencedirect.com/science/article/pii/S2667376222000282 |
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