Association of tumors having Epstein–Barr virus in surrounding lymphocytes with poor prognosis
Abstract Infection with certain viruses is an important cause of cancer. The Pan‐Cancer Analysis of Whole Genomes (PCAWG) Consortium recently analyzed the whole‐genome sequencing (WGS) data from 2656 cases across 21 cancer types, and indicated that Epstein–Barr virus (EBV) is detected in many differ...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.4967 |
| _version_ | 1811176419147907072 |
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| author | Norikazu Yogi Genki Usui Keisuke Matsusaka Masaki Fukuyo Ryoji Fujiki Motoaki Seki Shigetsugu Takano Hiroyuki Abe Teppei Morikawa Tetsuo Ushiku Masayuki Ohtsuka Atsushi Kaneda |
| author_facet | Norikazu Yogi Genki Usui Keisuke Matsusaka Masaki Fukuyo Ryoji Fujiki Motoaki Seki Shigetsugu Takano Hiroyuki Abe Teppei Morikawa Tetsuo Ushiku Masayuki Ohtsuka Atsushi Kaneda |
| author_sort | Norikazu Yogi |
| collection | DOAJ |
| description | Abstract Infection with certain viruses is an important cause of cancer. The Pan‐Cancer Analysis of Whole Genomes (PCAWG) Consortium recently analyzed the whole‐genome sequencing (WGS) data from 2656 cases across 21 cancer types, and indicated that Epstein–Barr virus (EBV) is detected in many different cancer cases at a higher frequency than previously reported. However, whether EBV‐positive cancer cases detected by WGS‐based screening correspond to those detected by conventional histopathological techniques is still unclear. In this study, to elucidate the involvement of EBV in various cancers, we reanalyzed the WGS data of the PCAWG cohort combined with the analysis of clinical samples of gastric and pancreatic cancer in our cohort. Based on EBV copy number in each case, we classified tumors into three subgroups: EBV‐High, EBV‐Low, and EBV‐Negative. The EBV‐High subgroup was found to be EBV‐positive in the cancer cells themselves, whereas the EBV‐Low subgroup was EBV‐positive in the surrounding lymphocytes. Further, the EBV‐Low subgroup showed a significantly worse prognosis for both gastric cancer and across cancer types. In summary, we classified tumors based on EBV copy number and found a unique cancer subgroup, EBV‐positive in the surrounding lymphocytes, which was associated with a poor prognosis. |
| first_indexed | 2024-04-10T19:52:18Z |
| format | Article |
| id | doaj.art-eef0e6833b7a4b999cf1edde36f2c194 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-10T19:52:18Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-eef0e6833b7a4b999cf1edde36f2c1942023-01-28T05:30:04ZengWileyCancer Medicine2045-76342023-01-011221122113610.1002/cam4.4967Association of tumors having Epstein–Barr virus in surrounding lymphocytes with poor prognosisNorikazu Yogi0Genki Usui1Keisuke Matsusaka2Masaki Fukuyo3Ryoji Fujiki4Motoaki Seki5Shigetsugu Takano6Hiroyuki Abe7Teppei Morikawa8Tetsuo Ushiku9Masayuki Ohtsuka10Atsushi Kaneda11Department of General Surgery, Graduate School of Medicine Chiba University JapanDepartment of Molecular Oncology, Graduate School of Medicine Chiba University JapanDepartment of Molecular Oncology, Graduate School of Medicine Chiba University JapanDepartment of Molecular Oncology, Graduate School of Medicine Chiba University JapanDepartment of Molecular Oncology, Graduate School of Medicine Chiba University JapanDepartment of Molecular Oncology, Graduate School of Medicine Chiba University JapanDepartment of General Surgery, Graduate School of Medicine Chiba University JapanDepartment of Pathology, Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Diagnostic Pathology NTT Medical Center Tokyo Tokyo JapanDepartment of Pathology, Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of General Surgery, Graduate School of Medicine Chiba University JapanDepartment of Molecular Oncology, Graduate School of Medicine Chiba University JapanAbstract Infection with certain viruses is an important cause of cancer. The Pan‐Cancer Analysis of Whole Genomes (PCAWG) Consortium recently analyzed the whole‐genome sequencing (WGS) data from 2656 cases across 21 cancer types, and indicated that Epstein–Barr virus (EBV) is detected in many different cancer cases at a higher frequency than previously reported. However, whether EBV‐positive cancer cases detected by WGS‐based screening correspond to those detected by conventional histopathological techniques is still unclear. In this study, to elucidate the involvement of EBV in various cancers, we reanalyzed the WGS data of the PCAWG cohort combined with the analysis of clinical samples of gastric and pancreatic cancer in our cohort. Based on EBV copy number in each case, we classified tumors into three subgroups: EBV‐High, EBV‐Low, and EBV‐Negative. The EBV‐High subgroup was found to be EBV‐positive in the cancer cells themselves, whereas the EBV‐Low subgroup was EBV‐positive in the surrounding lymphocytes. Further, the EBV‐Low subgroup showed a significantly worse prognosis for both gastric cancer and across cancer types. In summary, we classified tumors based on EBV copy number and found a unique cancer subgroup, EBV‐positive in the surrounding lymphocytes, which was associated with a poor prognosis.https://doi.org/10.1002/cam4.4967Epstein–Barr virus (EBV)gastric cancerlymphocytepancreatic cancer |
| spellingShingle | Norikazu Yogi Genki Usui Keisuke Matsusaka Masaki Fukuyo Ryoji Fujiki Motoaki Seki Shigetsugu Takano Hiroyuki Abe Teppei Morikawa Tetsuo Ushiku Masayuki Ohtsuka Atsushi Kaneda Association of tumors having Epstein–Barr virus in surrounding lymphocytes with poor prognosis Cancer Medicine Epstein–Barr virus (EBV) gastric cancer lymphocyte pancreatic cancer |
| title | Association of tumors having Epstein–Barr virus in surrounding lymphocytes with poor prognosis |
| title_full | Association of tumors having Epstein–Barr virus in surrounding lymphocytes with poor prognosis |
| title_fullStr | Association of tumors having Epstein–Barr virus in surrounding lymphocytes with poor prognosis |
| title_full_unstemmed | Association of tumors having Epstein–Barr virus in surrounding lymphocytes with poor prognosis |
| title_short | Association of tumors having Epstein–Barr virus in surrounding lymphocytes with poor prognosis |
| title_sort | association of tumors having epstein barr virus in surrounding lymphocytes with poor prognosis |
| topic | Epstein–Barr virus (EBV) gastric cancer lymphocyte pancreatic cancer |
| url | https://doi.org/10.1002/cam4.4967 |
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