Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore
Phytochemical investigation of the n-BuOH extract of the rhizomes of Anemone rivularis var. flore-minore led to the isolation of five new oleanane-type triterpenoid saponins 1–5, together with five known saponins 6–10. Their structures were determined by the extensive use of 1D and 2D NMR experiment...
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MDPI AG
2014-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/2/2121 |
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| author | Xiaoyang Wang Minchang Wang Min Xu Yi Wang Haifeng Tang Xiaoli Sun |
| author_facet | Xiaoyang Wang Minchang Wang Min Xu Yi Wang Haifeng Tang Xiaoli Sun |
| author_sort | Xiaoyang Wang |
| collection | DOAJ |
| description | Phytochemical investigation of the n-BuOH extract of the rhizomes of Anemone rivularis var. flore-minore led to the isolation of five new oleanane-type triterpenoid saponins 1–5, together with five known saponins 6–10. Their structures were determined by the extensive use of 1D and 2D NMR experiments, along with ESIMS analyses and acid hydrolysis. The aglycone of 4 and 5 was determined as 21α-hydroxyoleanolic acid, which was reported in this genus for the first time. The cytotoxicity of these compounds was evaluated against four human cancer cell line, including HL-60 (promyelocytic leukemia), HepG2 (hepatocellular carcinoma), A549 (lung carcinoma) and HeLa (cervical carcinoma). The monodesmosidic saponins 6–8 exhibited cytotoxic activity toward all tested cancer cell lines, with IC50 values in the 7.25–22.38 μM range. |
| first_indexed | 2024-12-23T05:28:39Z |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-23T05:28:39Z |
| publishDate | 2014-02-01 |
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| record_format | Article |
| series | Molecules |
| spelling | doaj.art-eef0ea898ddf4eed8683f32daaad57642022-12-21T17:58:33ZengMDPI AGMolecules1420-30492014-02-011922121213410.3390/molecules19022121molecules19022121Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minoreXiaoyang Wang0Minchang Wang1Min Xu2Yi Wang3Haifeng Tang4Xiaoli Sun5Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, ChinaNuclear Magnetic Resonance Center, Xi'an Modern Chemistry Research Institute, Xi'an 710065, ChinaNuclear Magnetic Resonance Center, Xi'an Modern Chemistry Research Institute, Xi'an 710065, ChinaInstitute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, ChinaDepartment of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, ChinaDepartment of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, ChinaPhytochemical investigation of the n-BuOH extract of the rhizomes of Anemone rivularis var. flore-minore led to the isolation of five new oleanane-type triterpenoid saponins 1–5, together with five known saponins 6–10. Their structures were determined by the extensive use of 1D and 2D NMR experiments, along with ESIMS analyses and acid hydrolysis. The aglycone of 4 and 5 was determined as 21α-hydroxyoleanolic acid, which was reported in this genus for the first time. The cytotoxicity of these compounds was evaluated against four human cancer cell line, including HL-60 (promyelocytic leukemia), HepG2 (hepatocellular carcinoma), A549 (lung carcinoma) and HeLa (cervical carcinoma). The monodesmosidic saponins 6–8 exhibited cytotoxic activity toward all tested cancer cell lines, with IC50 values in the 7.25–22.38 μM range.http://www.mdpi.com/1420-3049/19/2/2121Anemone rivularis var. flore-minoretriterpenoid saponincytotoxicity |
| spellingShingle | Xiaoyang Wang Minchang Wang Min Xu Yi Wang Haifeng Tang Xiaoli Sun Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore Molecules Anemone rivularis var. flore-minore triterpenoid saponin cytotoxicity |
| title | Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore |
| title_full | Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore |
| title_fullStr | Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore |
| title_full_unstemmed | Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore |
| title_short | Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore |
| title_sort | cytotoxic oleanane type triterpenoid saponins from the rhizomes of anemone rivularis var flore minore |
| topic | Anemone rivularis var. flore-minore triterpenoid saponin cytotoxicity |
| url | http://www.mdpi.com/1420-3049/19/2/2121 |
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