Monoclinic Paracetamol vs. Paracetamol-4,4′-Bipyridine Co-Crystal; What Is the Difference? A Charge Density Study

Monoclinic Paracetamol vs. Paracetamol-4,4′-Bipyridine Co-Crystal; What Is the Difference? A Charge Density Study

Paracetamol (PCM) has two well-documented polymorphic forms at room temperature; monoclinic Form I is more stable than the other orthorhombic Form II. Form II exhibits improved tabletting properties compared to Form I due to low shearing forces; however, difficulties in its manufacture have limited...

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Bibliographic Details
Main Authors: Jonathan J. Du, Felcia Lai, Linda Váradi, Peter A. Williams, Paul W. Groundwater, James A. Platts, David E. Hibbs, Jacob Overgaard
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Crystals
Subjects:
paracetamol
charge density study
tableting performance
co-crystals
Online Access:http://www.mdpi.com/2073-4352/8/1/46

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