Quantifying sodium [18F]fluoride uptake in abdominal aortic aneurysms
Abstract Background Aortic microcalcification activity is a recently described method of measuring aortic sodium [18F]fluoride uptake in the thoracic aorta on positron emission tomography. In this study, we aimed to compare and to modify this method for use within the infrarenal aorta of patients wi...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-06-01
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| Series: | EJNMMI Research |
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| Online Access: | https://doi.org/10.1186/s13550-022-00904-z |
| _version_ | 1818253244056469504 |
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| author | Samuel Debono Jennifer Nash Alexander J. Fletcher Maaz B. J. Syed Scott I. Semple Edwin J. R. van Beek Alison Fletcher Sebastien Cadet Michelle C. Williams Damini Dey Piotr J. Slomka Rachael O. Forsythe Marc R. Dweck David E. Newby |
| author_facet | Samuel Debono Jennifer Nash Alexander J. Fletcher Maaz B. J. Syed Scott I. Semple Edwin J. R. van Beek Alison Fletcher Sebastien Cadet Michelle C. Williams Damini Dey Piotr J. Slomka Rachael O. Forsythe Marc R. Dweck David E. Newby |
| author_sort | Samuel Debono |
| collection | DOAJ |
| description | Abstract Background Aortic microcalcification activity is a recently described method of measuring aortic sodium [18F]fluoride uptake in the thoracic aorta on positron emission tomography. In this study, we aimed to compare and to modify this method for use within the infrarenal aorta of patients with abdominal aortic aneurysms. Methods Twenty-five patients with abdominal aortic aneurysms underwent an sodium [18F]fluoride positron emission tomography and computed tomography scan. Maximum and mean tissue-to-background ratios (TBR) and abdominal aortic microcalcification activity were determined following application of a thresholding and variable radius method to correct for vertebral sodium [18F]fluoride signal spill-over and the nonlinear changes in aortic diameter, respectively. Agreement between the methods, and repeatability of these approaches were assessed. Results The aortic microcalcification activity method was much quicker to perform than the TBR method (14 versus 40 min, p < 0.001). There was moderate-to-good agreement between TBR and aortic microcalcification activity measurements for maximum (interclass correlation co-efficient, 0.67) and mean (interclass correlation co-efficient, 0.88) values. These correlations sequentially improved with the application of thresholding (intraclass correlation coefficient 0.93, 95% confidence interval 0.89–0.95) and variable diameter (intraclass correlation coefficient 0.97, 95% confidence interval 0.94–0.99) techniques. The optimised method had good intra-observer (mean 1.57 ± 0.42, bias 0.08, co-efficient of repeatability 0.36 and limits of agreement − 0.43 to 0.43) and inter-observer (mean 1.57 ± 0.42, bias 0.08, co-efficient of repeatability 0.47 and limits of agreement − 0.53 to 0.53) repeatability. Conclusions Aortic microcalcification activity is a quick and simple method which demonstrates good intra-observer and inter-observer repeatabilities and provides measures of sodium [18F]fluoride uptake that are comparable to established methods. |
| first_indexed | 2024-12-12T16:36:59Z |
| format | Article |
| id | doaj.art-eef14a70d0534dd98dfdb62485573ed7 |
| institution | Directory Open Access Journal |
| issn | 2191-219X |
| language | English |
| last_indexed | 2024-12-12T16:36:59Z |
| publishDate | 2022-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj.art-eef14a70d0534dd98dfdb62485573ed72022-12-22T00:18:39ZengSpringerOpenEJNMMI Research2191-219X2022-06-0112111010.1186/s13550-022-00904-zQuantifying sodium [18F]fluoride uptake in abdominal aortic aneurysmsSamuel Debono0Jennifer Nash1Alexander J. Fletcher2Maaz B. J. Syed3Scott I. Semple4Edwin J. R. van Beek5Alison Fletcher6Sebastien Cadet7Michelle C. Williams8Damini Dey9Piotr J. Slomka10Rachael O. Forsythe11Marc R. Dweck12David E. Newby13The University of Edinburgh Centre for Cardiovascular Science, Chancellor’s Building, University of EdinburghThe University of Edinburgh Centre for Cardiovascular Science, Chancellor’s Building, University of EdinburghThe University of Edinburgh Centre for Cardiovascular Science, Chancellor’s Building, University of EdinburghThe University of Edinburgh Centre for Cardiovascular Science, Chancellor’s Building, University of EdinburghThe University of Edinburgh Centre for Cardiovascular Science, Chancellor’s Building, University of EdinburghThe University of Edinburgh Centre for Cardiovascular Science, Chancellor’s Building, University of EdinburghEdinburgh Imaging Facility, Queen’s Medical Research Institute, University of EdinburghDivision of Artificial Intelligence, Department of Medicine, Cedars-Sinai Medical Centre, Biomedical Imaging Research InstituteThe University of Edinburgh Centre for Cardiovascular Science, Chancellor’s Building, University of EdinburghDivision of Artificial Intelligence, Department of Medicine, Cedars-Sinai Medical Centre, Biomedical Imaging Research InstituteDivision of Artificial Intelligence, Department of Medicine, Cedars-Sinai Medical Centre, Biomedical Imaging Research InstituteThe University of Edinburgh Centre for Cardiovascular Science, Chancellor’s Building, University of EdinburghThe University of Edinburgh Centre for Cardiovascular Science, Chancellor’s Building, University of EdinburghThe University of Edinburgh Centre for Cardiovascular Science, Chancellor’s Building, University of EdinburghAbstract Background Aortic microcalcification activity is a recently described method of measuring aortic sodium [18F]fluoride uptake in the thoracic aorta on positron emission tomography. In this study, we aimed to compare and to modify this method for use within the infrarenal aorta of patients with abdominal aortic aneurysms. Methods Twenty-five patients with abdominal aortic aneurysms underwent an sodium [18F]fluoride positron emission tomography and computed tomography scan. Maximum and mean tissue-to-background ratios (TBR) and abdominal aortic microcalcification activity were determined following application of a thresholding and variable radius method to correct for vertebral sodium [18F]fluoride signal spill-over and the nonlinear changes in aortic diameter, respectively. Agreement between the methods, and repeatability of these approaches were assessed. Results The aortic microcalcification activity method was much quicker to perform than the TBR method (14 versus 40 min, p < 0.001). There was moderate-to-good agreement between TBR and aortic microcalcification activity measurements for maximum (interclass correlation co-efficient, 0.67) and mean (interclass correlation co-efficient, 0.88) values. These correlations sequentially improved with the application of thresholding (intraclass correlation coefficient 0.93, 95% confidence interval 0.89–0.95) and variable diameter (intraclass correlation coefficient 0.97, 95% confidence interval 0.94–0.99) techniques. The optimised method had good intra-observer (mean 1.57 ± 0.42, bias 0.08, co-efficient of repeatability 0.36 and limits of agreement − 0.43 to 0.43) and inter-observer (mean 1.57 ± 0.42, bias 0.08, co-efficient of repeatability 0.47 and limits of agreement − 0.53 to 0.53) repeatability. Conclusions Aortic microcalcification activity is a quick and simple method which demonstrates good intra-observer and inter-observer repeatabilities and provides measures of sodium [18F]fluoride uptake that are comparable to established methods.https://doi.org/10.1186/s13550-022-00904-zAneurysmsPositron emission tomographyImage analysisRadiotracer |
| spellingShingle | Samuel Debono Jennifer Nash Alexander J. Fletcher Maaz B. J. Syed Scott I. Semple Edwin J. R. van Beek Alison Fletcher Sebastien Cadet Michelle C. Williams Damini Dey Piotr J. Slomka Rachael O. Forsythe Marc R. Dweck David E. Newby Quantifying sodium [18F]fluoride uptake in abdominal aortic aneurysms EJNMMI Research Aneurysms Positron emission tomography Image analysis Radiotracer |
| title | Quantifying sodium [18F]fluoride uptake in abdominal aortic aneurysms |
| title_full | Quantifying sodium [18F]fluoride uptake in abdominal aortic aneurysms |
| title_fullStr | Quantifying sodium [18F]fluoride uptake in abdominal aortic aneurysms |
| title_full_unstemmed | Quantifying sodium [18F]fluoride uptake in abdominal aortic aneurysms |
| title_short | Quantifying sodium [18F]fluoride uptake in abdominal aortic aneurysms |
| title_sort | quantifying sodium 18f fluoride uptake in abdominal aortic aneurysms |
| topic | Aneurysms Positron emission tomography Image analysis Radiotracer |
| url | https://doi.org/10.1186/s13550-022-00904-z |
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