AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors
Traditionally, xenobiotic receptors are known for their role in chemical sensing and detoxification, as receptor activation regulates the expression of various key enzymes and receptors. However, recent studies have highlighted that xenobiotic receptors also play a key role in the regulation of lipi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/23/2752 |
| _version_ | 1797400354739978240 |
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| author | Leonida Rakateli Rosanna Huchzermeier Emiel P. C. van der Vorst |
| author_facet | Leonida Rakateli Rosanna Huchzermeier Emiel P. C. van der Vorst |
| author_sort | Leonida Rakateli |
| collection | DOAJ |
| description | Traditionally, xenobiotic receptors are known for their role in chemical sensing and detoxification, as receptor activation regulates the expression of various key enzymes and receptors. However, recent studies have highlighted that xenobiotic receptors also play a key role in the regulation of lipid metabolism and therefore function also as metabolic sensors. Since dyslipidemia is a major risk factor for various cardiometabolic diseases, like atherosclerosis and non-alcoholic fatty liver disease, it is of major importance to understand the molecular mechanisms that are regulated by xenobiotic receptors. In this review, three major xenobiotic receptors will be discussed, being the aryl hydrocarbon receptor (AhR), pregnane X receptor (PXR) and the constitutive androstane receptor (CAR). Specifically, this review will focus on recent insights into the metabolic functions of these receptors, especially in the field of lipid metabolism and the associated dyslipidemia. |
| first_indexed | 2024-03-09T01:54:19Z |
| format | Article |
| id | doaj.art-eef165e01ac04eb0997c75f4f4ca8453 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T01:54:19Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-eef165e01ac04eb0997c75f4f4ca84532023-12-08T15:13:15ZengMDPI AGCells2073-44092023-11-011223275210.3390/cells12232752AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic SensorsLeonida Rakateli0Rosanna Huchzermeier1Emiel P. C. van der Vorst2Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, GermanyInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, GermanyInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, GermanyTraditionally, xenobiotic receptors are known for their role in chemical sensing and detoxification, as receptor activation regulates the expression of various key enzymes and receptors. However, recent studies have highlighted that xenobiotic receptors also play a key role in the regulation of lipid metabolism and therefore function also as metabolic sensors. Since dyslipidemia is a major risk factor for various cardiometabolic diseases, like atherosclerosis and non-alcoholic fatty liver disease, it is of major importance to understand the molecular mechanisms that are regulated by xenobiotic receptors. In this review, three major xenobiotic receptors will be discussed, being the aryl hydrocarbon receptor (AhR), pregnane X receptor (PXR) and the constitutive androstane receptor (CAR). Specifically, this review will focus on recent insights into the metabolic functions of these receptors, especially in the field of lipid metabolism and the associated dyslipidemia.https://www.mdpi.com/2073-4409/12/23/2752lipid metabolismcardiometabolic diseasesxenobiotic receptorsaryl hydrocarbon receptorpregnane X receptorconstitutive androstane receptor |
| spellingShingle | Leonida Rakateli Rosanna Huchzermeier Emiel P. C. van der Vorst AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors Cells lipid metabolism cardiometabolic diseases xenobiotic receptors aryl hydrocarbon receptor pregnane X receptor constitutive androstane receptor |
| title | AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors |
| title_full | AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors |
| title_fullStr | AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors |
| title_full_unstemmed | AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors |
| title_short | AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors |
| title_sort | ahr pxr and car from xenobiotic receptors to metabolic sensors |
| topic | lipid metabolism cardiometabolic diseases xenobiotic receptors aryl hydrocarbon receptor pregnane X receptor constitutive androstane receptor |
| url | https://www.mdpi.com/2073-4409/12/23/2752 |
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