A tRNA- and Anticodon-Centric View of the Evolution of Aminoacyl-tRNA Synthetases, tRNAomes, and the Genetic Code

A tRNA- and Anticodon-Centric View of the Evolution of Aminoacyl-tRNA Synthetases, tRNAomes, and the Genetic Code

Pathways of standard genetic code evolution remain conserved and apparent, particularly upon analysis of aminoacyl-tRNA synthetase (aaRS) lineages. Despite having incompatible active site folds, class I and class II aaRS are homologs by sequence. Specifically, structural class IA aaRS enzymes derive...

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Bibliographic Details
Main Authors: Yunsoo Kim, Kristopher Opron, Zachary F. Burton
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Life
Subjects:
anticodon
aminoacyl-tRNA synthetase
coevolution theory
“frozen accident”
genetic code
glycine
Phyre2
polyglycine
tRNAome
tRNA evolution
Online Access:https://www.mdpi.com/2075-1729/9/2/37

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