Genetic variant rs7758229 in 6q26-q27 is not associated with colorectal cancer risk in a Chinese population.
BACKGROUND: A recent genome-wide association study has identified a new genetic variant rs7758229 in SLC22A3 for colorectal cancer susceptibility in a Japanese population, but it is unknown whether this newly identified variant is associated with colorectal cancer in other populations, including the...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3595231?pdf=render |
| _version_ | 1818935498358390784 |
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| author | Lingjun Zhu Mulong Du Dongying Gu Lan Ma Haiyan Chu Na Tong Jinfei Chen Zhengdong Zhang Meilin Wang |
| author_facet | Lingjun Zhu Mulong Du Dongying Gu Lan Ma Haiyan Chu Na Tong Jinfei Chen Zhengdong Zhang Meilin Wang |
| author_sort | Lingjun Zhu |
| collection | DOAJ |
| description | BACKGROUND: A recent genome-wide association study has identified a new genetic variant rs7758229 in SLC22A3 for colorectal cancer susceptibility in a Japanese population, but it is unknown whether this newly identified variant is associated with colorectal cancer in other populations, including the Chinese population. METHODS: We examined the associations between rs7758229 and colorectal cancer risk among 1,147 cases and 1,203 controls matched by age and sex. Logistic regression model was used to assess the associations. RESULTS: No significant association was found between rs7758229 and colorectal cancer risk (OR = 0.95, 95%CI = 0.84-1.09, P = 0.463). Similar results were observed in the stratification of tumor location (OR = 0.94, 95%CI = 0.80-1.11, P = 0.481 for colon cancer, and OR = 0.96, 95%CI = 0.82-1.13, P = 0.621 for rectum cancer). CONCLUSIONS: Our findings did not support an association between rs7758229 in 6q26-q27 and the risk of colorectal cancer in a Chinese population. |
| first_indexed | 2024-12-20T05:21:07Z |
| format | Article |
| id | doaj.art-eef6948de5854204931ca9d9646c49ab |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T05:21:07Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-eef6948de5854204931ca9d9646c49ab2022-12-21T19:52:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5925610.1371/journal.pone.0059256Genetic variant rs7758229 in 6q26-q27 is not associated with colorectal cancer risk in a Chinese population.Lingjun ZhuMulong DuDongying GuLan MaHaiyan ChuNa TongJinfei ChenZhengdong ZhangMeilin WangBACKGROUND: A recent genome-wide association study has identified a new genetic variant rs7758229 in SLC22A3 for colorectal cancer susceptibility in a Japanese population, but it is unknown whether this newly identified variant is associated with colorectal cancer in other populations, including the Chinese population. METHODS: We examined the associations between rs7758229 and colorectal cancer risk among 1,147 cases and 1,203 controls matched by age and sex. Logistic regression model was used to assess the associations. RESULTS: No significant association was found between rs7758229 and colorectal cancer risk (OR = 0.95, 95%CI = 0.84-1.09, P = 0.463). Similar results were observed in the stratification of tumor location (OR = 0.94, 95%CI = 0.80-1.11, P = 0.481 for colon cancer, and OR = 0.96, 95%CI = 0.82-1.13, P = 0.621 for rectum cancer). CONCLUSIONS: Our findings did not support an association between rs7758229 in 6q26-q27 and the risk of colorectal cancer in a Chinese population.http://europepmc.org/articles/PMC3595231?pdf=render |
| spellingShingle | Lingjun Zhu Mulong Du Dongying Gu Lan Ma Haiyan Chu Na Tong Jinfei Chen Zhengdong Zhang Meilin Wang Genetic variant rs7758229 in 6q26-q27 is not associated with colorectal cancer risk in a Chinese population. PLoS ONE |
| title | Genetic variant rs7758229 in 6q26-q27 is not associated with colorectal cancer risk in a Chinese population. |
| title_full | Genetic variant rs7758229 in 6q26-q27 is not associated with colorectal cancer risk in a Chinese population. |
| title_fullStr | Genetic variant rs7758229 in 6q26-q27 is not associated with colorectal cancer risk in a Chinese population. |
| title_full_unstemmed | Genetic variant rs7758229 in 6q26-q27 is not associated with colorectal cancer risk in a Chinese population. |
| title_short | Genetic variant rs7758229 in 6q26-q27 is not associated with colorectal cancer risk in a Chinese population. |
| title_sort | genetic variant rs7758229 in 6q26 q27 is not associated with colorectal cancer risk in a chinese population |
| url | http://europepmc.org/articles/PMC3595231?pdf=render |
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