Prevalence of prediabetes in Mexico: a retrospective analysis of nationally representative surveys spanning 2016–2022Research in context
Summary: Background: Characterizing prediabetes phenotypes may be useful in guiding diabetes prevention efforts; however, heterogeneous criteria to define prediabetes have led to inconsistent prevalence estimates, particularly in low- and middle-income countries. Here, we estimated trends in predia...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | The Lancet Regional Health. Americas |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667193X23002144 |
| _version_ | 1797454319018049536 |
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| author | Carlos A. Fermín-Martínez César Daniel Paz-Cabrera Martín Roberto Basile-Alvarez Paulina Sánchez Castro Alejandra Núñez-Luna Jerónimo Perezalonso-Espinosa Daniel Ramírez-García Neftali Eduardo Antonio-Villa Arsenio Vargas-Vázquez Luisa Fernández-Chirino Karime Berenice Carrillo-Herrera Leslie Alitzel Cabrera-Quintana Rosalba Rojas-Martínez Jacqueline A. Seiglie Omar Yaxmehen Bello-Chavolla |
| author_facet | Carlos A. Fermín-Martínez César Daniel Paz-Cabrera Martín Roberto Basile-Alvarez Paulina Sánchez Castro Alejandra Núñez-Luna Jerónimo Perezalonso-Espinosa Daniel Ramírez-García Neftali Eduardo Antonio-Villa Arsenio Vargas-Vázquez Luisa Fernández-Chirino Karime Berenice Carrillo-Herrera Leslie Alitzel Cabrera-Quintana Rosalba Rojas-Martínez Jacqueline A. Seiglie Omar Yaxmehen Bello-Chavolla |
| author_sort | Carlos A. Fermín-Martínez |
| collection | DOAJ |
| description | Summary: Background: Characterizing prediabetes phenotypes may be useful in guiding diabetes prevention efforts; however, heterogeneous criteria to define prediabetes have led to inconsistent prevalence estimates, particularly in low- and middle-income countries. Here, we estimated trends in prediabetes prevalence in Mexico across different prediabetes definitions and their association with prevalent cardiometabolic conditions. Methods: We conducted a serial cross-sectional analysis of National Health and Nutrition Surveys in Mexico (2016–2022), totalling 22 081 Mexican adults. After excluding individuals with diagnosed or undiagnosed diabetes, we defined prediabetes using ADA (impaired fasting glucose [IFG] 100–125 mg/dL and/or HbA1c 5.7–6.4%), WHO (IFG 110–125 mg/dL), and IEC criteria (HbA1c 6.0–6.4%). Prevalence trends of prediabetes over time were evaluated using weighted Poisson regression and its association with prevalent cardiometabolic conditions with weighted logistic regression. Findings: The prevalence of prediabetes (either IFG or high HbA1c [ADA]) in Mexico was 20.9% in 2022. Despite an overall downward trend in prediabetes (RR 0.973, 95% CI 0.957–0.988), this was primarily driven by decreases in prediabetes by ADA-IFG (RR 0.898, 95% CI 0.880–0.917) and WHO-IFG criteria (RR 0.919, 95% CI 0.886–0.953), while prediabetes by ADA-HbA1c (RR 1.055, 95% CI 1.033–1.077) and IEC-HbA1C criteria (RR 1.085, 95% CI 1.045–1.126) increased over time. Prediabetes prevalence increased over time in adults >40 years, with central obesity, self-identified as indigenous or living in urban areas. For all definitions, prediabetes was associated with an increased risk of cardiometabolic conditions. Interpretation: Prediabetes rates in Mexico from 2016 to 2022 varied based on defining criteria but consistently increased for HbA1c-based definitions and high-risk subgroups. Funding: This research was supported by Instituto Nacional de Geriatría in Mexico. JAS was supported by NIH/NIDDK Grant# K23DK135798. |
| first_indexed | 2024-03-09T15:35:34Z |
| format | Article |
| id | doaj.art-eef6f5bfeed742e8921b70feee8ccf64 |
| institution | Directory Open Access Journal |
| issn | 2667-193X |
| language | English |
| last_indexed | 2024-03-09T15:35:34Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Americas |
| spelling | doaj.art-eef6f5bfeed742e8921b70feee8ccf642023-11-26T05:14:25ZengElsevierThe Lancet Regional Health. Americas2667-193X2023-12-0128100640Prevalence of prediabetes in Mexico: a retrospective analysis of nationally representative surveys spanning 2016–2022Research in contextCarlos A. Fermín-Martínez0César Daniel Paz-Cabrera1Martín Roberto Basile-Alvarez2Paulina Sánchez Castro3Alejandra Núñez-Luna4Jerónimo Perezalonso-Espinosa5Daniel Ramírez-García6Neftali Eduardo Antonio-Villa7Arsenio Vargas-Vázquez8Luisa Fernández-Chirino9Karime Berenice Carrillo-Herrera10Leslie Alitzel Cabrera-Quintana11Rosalba Rojas-Martínez12Jacqueline A. Seiglie13Omar Yaxmehen Bello-Chavolla14Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico; MD/PhD (PECEM) Program, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoResearch Division, Instituto Nacional de Geriatría, Mexico City, Mexico; Especialidad en Medicina Preventiva, Instituto Nacional de Salud Pública, Mexico City, MexicoResearch Division, Instituto Nacional de Geriatría, Mexico City, Mexico; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoResearch Division, Instituto Nacional de Geriatría, Mexico City, Mexico; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoResearch Division, Instituto Nacional de Geriatría, Mexico City, Mexico; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoEspecialidad en Medicina Preventiva, Instituto Nacional de Salud Pública, Mexico City, MexicoResearch Division, Instituto Nacional de Geriatría, Mexico City, Mexico; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoDepartmento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoEspecialidad en Medicina Preventiva, Instituto Nacional de Salud Pública, Mexico City, MexicoResearch Division, Instituto Nacional de Geriatría, Mexico City, MexicoFacultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoFacultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoInstituto Nacional de Salud Pública, Cuernavaca, Morelos, MexicoDiabetes Unit, Massachusetts General Hospital, Harvard Medical School, MA, USA; Department of Medicine, Harvard Medical School, MA, USAResearch Division, Instituto Nacional de Geriatría, Mexico City, Mexico; Corresponding author. Division of Research, Instituto Nacional de Geriatría, Anillo Perif. 2767, San Jerónimo Lídice, La Magdalena Contreras, 10200, Mexico City, Mexico.Summary: Background: Characterizing prediabetes phenotypes may be useful in guiding diabetes prevention efforts; however, heterogeneous criteria to define prediabetes have led to inconsistent prevalence estimates, particularly in low- and middle-income countries. Here, we estimated trends in prediabetes prevalence in Mexico across different prediabetes definitions and their association with prevalent cardiometabolic conditions. Methods: We conducted a serial cross-sectional analysis of National Health and Nutrition Surveys in Mexico (2016–2022), totalling 22 081 Mexican adults. After excluding individuals with diagnosed or undiagnosed diabetes, we defined prediabetes using ADA (impaired fasting glucose [IFG] 100–125 mg/dL and/or HbA1c 5.7–6.4%), WHO (IFG 110–125 mg/dL), and IEC criteria (HbA1c 6.0–6.4%). Prevalence trends of prediabetes over time were evaluated using weighted Poisson regression and its association with prevalent cardiometabolic conditions with weighted logistic regression. Findings: The prevalence of prediabetes (either IFG or high HbA1c [ADA]) in Mexico was 20.9% in 2022. Despite an overall downward trend in prediabetes (RR 0.973, 95% CI 0.957–0.988), this was primarily driven by decreases in prediabetes by ADA-IFG (RR 0.898, 95% CI 0.880–0.917) and WHO-IFG criteria (RR 0.919, 95% CI 0.886–0.953), while prediabetes by ADA-HbA1c (RR 1.055, 95% CI 1.033–1.077) and IEC-HbA1C criteria (RR 1.085, 95% CI 1.045–1.126) increased over time. Prediabetes prevalence increased over time in adults >40 years, with central obesity, self-identified as indigenous or living in urban areas. For all definitions, prediabetes was associated with an increased risk of cardiometabolic conditions. Interpretation: Prediabetes rates in Mexico from 2016 to 2022 varied based on defining criteria but consistently increased for HbA1c-based definitions and high-risk subgroups. Funding: This research was supported by Instituto Nacional de Geriatría in Mexico. JAS was supported by NIH/NIDDK Grant# K23DK135798.http://www.sciencedirect.com/science/article/pii/S2667193X23002144PrediabetesGlucose metabolismInsulin resistanceCardiometabolic risk |
| spellingShingle | Carlos A. Fermín-Martínez César Daniel Paz-Cabrera Martín Roberto Basile-Alvarez Paulina Sánchez Castro Alejandra Núñez-Luna Jerónimo Perezalonso-Espinosa Daniel Ramírez-García Neftali Eduardo Antonio-Villa Arsenio Vargas-Vázquez Luisa Fernández-Chirino Karime Berenice Carrillo-Herrera Leslie Alitzel Cabrera-Quintana Rosalba Rojas-Martínez Jacqueline A. Seiglie Omar Yaxmehen Bello-Chavolla Prevalence of prediabetes in Mexico: a retrospective analysis of nationally representative surveys spanning 2016–2022Research in context The Lancet Regional Health. Americas Prediabetes Glucose metabolism Insulin resistance Cardiometabolic risk |
| title | Prevalence of prediabetes in Mexico: a retrospective analysis of nationally representative surveys spanning 2016–2022Research in context |
| title_full | Prevalence of prediabetes in Mexico: a retrospective analysis of nationally representative surveys spanning 2016–2022Research in context |
| title_fullStr | Prevalence of prediabetes in Mexico: a retrospective analysis of nationally representative surveys spanning 2016–2022Research in context |
| title_full_unstemmed | Prevalence of prediabetes in Mexico: a retrospective analysis of nationally representative surveys spanning 2016–2022Research in context |
| title_short | Prevalence of prediabetes in Mexico: a retrospective analysis of nationally representative surveys spanning 2016–2022Research in context |
| title_sort | prevalence of prediabetes in mexico a retrospective analysis of nationally representative surveys spanning 2016 2022research in context |
| topic | Prediabetes Glucose metabolism Insulin resistance Cardiometabolic risk |
| url | http://www.sciencedirect.com/science/article/pii/S2667193X23002144 |
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