Commentary on oncolytic viruses: past, present, and future

Whither oncolytic viruses? From the peak of their popularity in the early 2000s, when the ONYX-015 adenovirus had just entered the clinic, and then again in 2015 when the Food and Drug Administration-approved talimogene laherparepvec (also known as OncoVEXGM-CSF), which briefly revived interest, onc...

Full description

Bibliographic Details
Main Authors: Christopher Larson, Bryan Oronsky, Tony R Reid
Format: Article
Language:English
Published: BMJ Publishing Group 2023-12-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/12/e007905.full
Description
Summary:Whither oncolytic viruses? From the peak of their popularity in the early 2000s, when the ONYX-015 adenovirus had just entered the clinic, and then again in 2015 when the Food and Drug Administration-approved talimogene laherparepvec (also known as OncoVEXGM-CSF), which briefly revived interest, oncolytic viruses (OVs) have mostly fallen out of favor despite the many pharmaceutical companies with OVs in development.This commentary enumerates and addresses the core conceptions, perceptions, and misconceptions that characterize the current ‘trough of disillusionment’ in which the field of anticancer virotherapy finds itself and suggests reasons for optimism.
ISSN:2051-1426