Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility
Spermatogenesis is a very complex process with an intricate transcriptional regulation. The transition from the diploid to the haploid state requires the involvement of specialized genes in meiosis, among other specific functions for the formation of the spermatozoon. The transcription factor cAMP-r...
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| author | Diego Eduardo Sánchez-Jasso Sergio Federico López-Guzmán Rosa Maria Bermúdez-Cruz Norma Oviedo |
| author_facet | Diego Eduardo Sánchez-Jasso Sergio Federico López-Guzmán Rosa Maria Bermúdez-Cruz Norma Oviedo |
| author_sort | Diego Eduardo Sánchez-Jasso |
| collection | DOAJ |
| description | Spermatogenesis is a very complex process with an intricate transcriptional regulation. The transition from the diploid to the haploid state requires the involvement of specialized genes in meiosis, among other specific functions for the formation of the spermatozoon. The transcription factor cAMP-response element modulator (CREM) is a key modulator that triggers the differentiation of the germ cell into the spermatozoon through the modification of gene expression. CREM has multiple repressor and activator isoforms whose expression is tissue-cell-type specific and tightly regulated by various factors at the transcriptional, post-transcriptional and post-translational level. The activator isoform CREMτ controls the expression of several relevant genes in post-meiotic stages of spermatogenesis. In addition, exposure to xenobiotics negatively affects <i>CREMτ</i> expression, which is linked to male infertility. On the other hand, antioxidants could have a positive effect on <i>CREMτ</i> expression and improve sperm parameters in idiopathically infertile men. Therefore, <i>CREM</i> expression could be used as a biomarker to detect and even counteract male infertility. This review examines the importance of CREM as a transcription factor for sperm production and its relevance in male fertility, infertility and the response to environmental xenobiotics that may affect <i>CREMτ</i> expression and the downstream regulation that alters male fertility. Also, some health disorders in which <i>CREM</i> expression is altered are discussed. |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:53:52Z |
| publishDate | 2023-08-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-eef93a75e6ac45bfbeed34106ba48f4a2023-11-19T01:24:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124161255810.3390/ijms241612558Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male FertilityDiego Eduardo Sánchez-Jasso0Sergio Federico López-Guzmán1Rosa Maria Bermúdez-Cruz2Norma Oviedo3Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Mexico City 07360, MexicoDepartamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Mexico City 07360, MexicoDepartamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Mexico City 07360, MexicoUnidad de Investigación Médica en Immunología e Infectología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social (IMSS), Mexico City 02990, MexicoSpermatogenesis is a very complex process with an intricate transcriptional regulation. The transition from the diploid to the haploid state requires the involvement of specialized genes in meiosis, among other specific functions for the formation of the spermatozoon. The transcription factor cAMP-response element modulator (CREM) is a key modulator that triggers the differentiation of the germ cell into the spermatozoon through the modification of gene expression. CREM has multiple repressor and activator isoforms whose expression is tissue-cell-type specific and tightly regulated by various factors at the transcriptional, post-transcriptional and post-translational level. The activator isoform CREMτ controls the expression of several relevant genes in post-meiotic stages of spermatogenesis. In addition, exposure to xenobiotics negatively affects <i>CREMτ</i> expression, which is linked to male infertility. On the other hand, antioxidants could have a positive effect on <i>CREMτ</i> expression and improve sperm parameters in idiopathically infertile men. Therefore, <i>CREM</i> expression could be used as a biomarker to detect and even counteract male infertility. This review examines the importance of CREM as a transcription factor for sperm production and its relevance in male fertility, infertility and the response to environmental xenobiotics that may affect <i>CREMτ</i> expression and the downstream regulation that alters male fertility. Also, some health disorders in which <i>CREM</i> expression is altered are discussed.https://www.mdpi.com/1422-0067/24/16/12558CREMspermatogenesismale fertilitygene regulationCREM isoforms |
| spellingShingle | Diego Eduardo Sánchez-Jasso Sergio Federico López-Guzmán Rosa Maria Bermúdez-Cruz Norma Oviedo Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility International Journal of Molecular Sciences CREM spermatogenesis male fertility gene regulation CREM isoforms |
| title | Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility |
| title_full | Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility |
| title_fullStr | Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility |
| title_full_unstemmed | Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility |
| title_short | Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility |
| title_sort | novel aspects of camp response element modulator crem role in spermatogenesis and male fertility |
| topic | CREM spermatogenesis male fertility gene regulation CREM isoforms |
| url | https://www.mdpi.com/1422-0067/24/16/12558 |
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