Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles

Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles

The short QT syndrome (SQTS) is a rare cardiac disorder associated with arrhythmias and sudden death. Gain-of-function mutations to potassium channels mediating the rapid delayed rectifier current, IKr, underlie SQTS variant 1 (SQT1), in which treatment with Na+ and K+ channel blocking class Ia anti...

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Bibliographic Details
Main Authors: Dominic G. Whittaker, Haibo Ni, Alan P. Benson, Jules C. Hancox, Henggui Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Physiology
Subjects:
arrhythmia
short QT syndrome
drug modeling
potassium channels
human ventricles
class 1a anti-arrhythmics
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00759/full

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