Comparison of external system and implanted system in intrathecal therapy for refractory cancer pain in China: A retrospective study
Abstract Introduction Intrathecal therapy (ITT) via an implanted system was demonstrated for the treatment of refractory cancer pain for decades. Recently, the dissemination of ITT is enhanced in an external system way in Asia for a lower implantation cost. This study compares the efficacy, safety,...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2851 |
| _version_ | 1797893739900829696 |
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| author | Wangjun Qin Li Zhao Botao Liu Yang Yang Peng Mao Liyuan Xu Pengmei Li Yongguang Shang Lei Zhang Bifa Fan |
| author_facet | Wangjun Qin Li Zhao Botao Liu Yang Yang Peng Mao Liyuan Xu Pengmei Li Yongguang Shang Lei Zhang Bifa Fan |
| author_sort | Wangjun Qin |
| collection | DOAJ |
| description | Abstract Introduction Intrathecal therapy (ITT) via an implanted system was demonstrated for the treatment of refractory cancer pain for decades. Recently, the dissemination of ITT is enhanced in an external system way in Asia for a lower implantation cost. This study compares the efficacy, safety, and cost of the two ITT systems in refractory cancer pain patients in China. Methods One hundred and thirty‐nine cancer pain patients who underwent implantation of the ITT system were included. One hundred and three patients received ITT via the external system (external group), while 36 patients received ITT via the implanted system (implanted group). A 1:2 propensity score matching procedure was used to yield a total of 89 patients for the final analysis. Medical records of included patients were retrospectively reviewed and pain scores, incidences of complications, and costs were compared. Results ITT via the external system provided pain relief as potent as ITT via the implanted system but was less time‐consuming in the implantation phase (13 vs. 19 days, p < .01). Nausea/vomiting and urinary retention were the most frequent adverse events in both external and implanted groups (32.14%, 16.07% vs. 36.36%, 21.21%). No significant difference was found in the incidences of all kinds of complications. Compared to the implanted group, the external group cost less for the initial implantation (7268 vs. 26,275 US dollar [USD], p < .001) but had a significant higher maintenance cost (606.62 vs. 20.23 USD calculated monthly, p < .001). Conclusions ITT via the external system is as effective and safe as that via the implanted system and has the advantage of being cheap in the upfront implantation but costs more during the maintenance process in China. |
| first_indexed | 2024-04-10T06:57:44Z |
| format | Article |
| id | doaj.art-eefe479e529b4d3bbcdea98a9141532f |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-04-10T06:57:44Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-eefe479e529b4d3bbcdea98a9141532f2023-02-28T07:01:06ZengWileyBrain and Behavior2162-32792023-01-01131n/an/a10.1002/brb3.2851Comparison of external system and implanted system in intrathecal therapy for refractory cancer pain in China: A retrospective studyWangjun Qin0Li Zhao1Botao Liu2Yang Yang3Peng Mao4Liyuan Xu5Pengmei Li6Yongguang Shang7Lei Zhang8Bifa Fan9Department of Pharmacy China‐Japan Friendship Hospital Beijing ChinaDepartment of Pharmacy China‐Japan Friendship Hospital Beijing ChinaDepartment of Pain Management China‐Japan Friendship Hospital Beijing ChinaDepartment of Pain Management China‐Japan Friendship Hospital Beijing ChinaDepartment of Pain Management China‐Japan Friendship Hospital Beijing ChinaDepartment of Pain Management China‐Japan Friendship Hospital Beijing ChinaDepartment of Pharmacy China‐Japan Friendship Hospital Beijing ChinaDepartment of Pharmacy China‐Japan Friendship Hospital Beijing ChinaDepartment of Pharmacy China‐Japan Friendship Hospital Beijing ChinaDepartment of Pain Management China‐Japan Friendship Hospital Beijing ChinaAbstract Introduction Intrathecal therapy (ITT) via an implanted system was demonstrated for the treatment of refractory cancer pain for decades. Recently, the dissemination of ITT is enhanced in an external system way in Asia for a lower implantation cost. This study compares the efficacy, safety, and cost of the two ITT systems in refractory cancer pain patients in China. Methods One hundred and thirty‐nine cancer pain patients who underwent implantation of the ITT system were included. One hundred and three patients received ITT via the external system (external group), while 36 patients received ITT via the implanted system (implanted group). A 1:2 propensity score matching procedure was used to yield a total of 89 patients for the final analysis. Medical records of included patients were retrospectively reviewed and pain scores, incidences of complications, and costs were compared. Results ITT via the external system provided pain relief as potent as ITT via the implanted system but was less time‐consuming in the implantation phase (13 vs. 19 days, p < .01). Nausea/vomiting and urinary retention were the most frequent adverse events in both external and implanted groups (32.14%, 16.07% vs. 36.36%, 21.21%). No significant difference was found in the incidences of all kinds of complications. Compared to the implanted group, the external group cost less for the initial implantation (7268 vs. 26,275 US dollar [USD], p < .001) but had a significant higher maintenance cost (606.62 vs. 20.23 USD calculated monthly, p < .001). Conclusions ITT via the external system is as effective and safe as that via the implanted system and has the advantage of being cheap in the upfront implantation but costs more during the maintenance process in China.https://doi.org/10.1002/brb3.2851comparative analysisintrathecal therapyrefractory cancer painrisk management |
| spellingShingle | Wangjun Qin Li Zhao Botao Liu Yang Yang Peng Mao Liyuan Xu Pengmei Li Yongguang Shang Lei Zhang Bifa Fan Comparison of external system and implanted system in intrathecal therapy for refractory cancer pain in China: A retrospective study Brain and Behavior comparative analysis intrathecal therapy refractory cancer pain risk management |
| title | Comparison of external system and implanted system in intrathecal therapy for refractory cancer pain in China: A retrospective study |
| title_full | Comparison of external system and implanted system in intrathecal therapy for refractory cancer pain in China: A retrospective study |
| title_fullStr | Comparison of external system and implanted system in intrathecal therapy for refractory cancer pain in China: A retrospective study |
| title_full_unstemmed | Comparison of external system and implanted system in intrathecal therapy for refractory cancer pain in China: A retrospective study |
| title_short | Comparison of external system and implanted system in intrathecal therapy for refractory cancer pain in China: A retrospective study |
| title_sort | comparison of external system and implanted system in intrathecal therapy for refractory cancer pain in china a retrospective study |
| topic | comparative analysis intrathecal therapy refractory cancer pain risk management |
| url | https://doi.org/10.1002/brb3.2851 |
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