Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease
ObjectiveThere have been no studies on the association between changes in smoking and alcohol consumption or combined changes in smoking and alcohol consumption frequencies and PD risk. To assess the influence of changes in smoking and alcohol consumption on the risk of Parkinson’s disease (PD).Meth...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1223310/full |
| _version_ | 1797687224718852096 |
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| author | Se Young Jung Se Young Jung Sohyun Chun Eun Bin Cho Kyungdo Han Juhwan Yoo Yohwan Yeo Jung Eun Yoo Su Min Jeong Ju-Hong Min Ju-Hong Min Ju-Hong Min Dong Wook Shin Dong Wook Shin Dong Wook Shin |
| author_facet | Se Young Jung Se Young Jung Sohyun Chun Eun Bin Cho Kyungdo Han Juhwan Yoo Yohwan Yeo Jung Eun Yoo Su Min Jeong Ju-Hong Min Ju-Hong Min Ju-Hong Min Dong Wook Shin Dong Wook Shin Dong Wook Shin |
| author_sort | Se Young Jung |
| collection | DOAJ |
| description | ObjectiveThere have been no studies on the association between changes in smoking and alcohol consumption or combined changes in smoking and alcohol consumption frequencies and PD risk. To assess the influence of changes in smoking and alcohol consumption on the risk of Parkinson’s disease (PD).MethodsNational Health Insurance Service (NHIS) database between January 2009 to December 2011 was analyzed. A total of 3,931,741 patients were included. Study participants were followed up for the incidence of PD until December 2017.ResultsCompared to the sustained non-smokers, sustained light smokers (adjusted hazard ratio [aHR] 0.80, 95% confidence interval [CI] 0.75–0.85), sustained moderate smokers (aHR 0.54, 95% CI 0.47–0.61), and sustained heavy smokers (aHR 0.49, 95% CI 0.44–0.55) had a lower risk of PD. Compared to those who sustained non-drinking, sustained light drinkers (aHR 0.85 95% CI 0.89–0.91), sustained moderate drinkers (aHR 0.68, 95% CI 0.60–0.78), and sustained heavy drinkers (aHR 0.77, 95% CI 0.68–0.87) showed decreased risk of PD. Among non-drinkers, those who started drinking to a light level were at decreased risk of PD (aHR 0.84, 95% CI 0.77–0.91). Among non-smoking and non-drinking participants, those who initiated smoking only (aHR 0.78, 95% CI 0.70–0.86), drinking only (aHR 0.77, 95% CI 0.68–0.87), and both smoking and drinking (aHR 0.69, 95% CI 0.58–0.82) showed decreased risk of PD.ConclusionSmoking is associated with decreased risk of PD with a dose–response relationship. Alcohol consumption at a light level may also be associated with decreased risk of PD. Further studies are warranted to find the possible mechanisms for the protective effects of smoking and drinking on PD, which may present insights into the etiology of PD. |
| first_indexed | 2024-03-12T01:15:12Z |
| format | Article |
| id | doaj.art-eeff2170d04d4e78860d1facd5440f25 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-12T01:15:12Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-eeff2170d04d4e78860d1facd5440f252023-09-13T16:23:29ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-09-011510.3389/fnagi.2023.12233101223310Changes in smoking, alcohol consumption, and the risk of Parkinson’s diseaseSe Young Jung0Se Young Jung1Sohyun Chun2Eun Bin Cho3Kyungdo Han4Juhwan Yoo5Yohwan Yeo6Jung Eun Yoo7Su Min Jeong8Ju-Hong Min9Ju-Hong Min10Ju-Hong Min11Dong Wook Shin12Dong Wook Shin13Dong Wook Shin14Department of Family Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaDepartment of Digital Healthcare, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaInternational Healthcare Center, Samsung Medical Center, Seoul, Republic of KoreaDepartment of Neurology, College of Medicine, Gyeongsang Institute of Health Science, Gyeongsang National University, Jinju, Republic of KoreaDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of KoreaDepartment of Biostatistics, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Family Medicine/Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDepartment of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of KoreaDepartment of Family Medicine/Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea0Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea1Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of KoreaDepartment of Family Medicine/Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea2Department of Clinical Study Design and Evaluation, Samsung Advanced Institute of Health Science and Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea3Center for Wireless and Population Health Systems, University of California, San Diego, La Jolla, CA, United StatesObjectiveThere have been no studies on the association between changes in smoking and alcohol consumption or combined changes in smoking and alcohol consumption frequencies and PD risk. To assess the influence of changes in smoking and alcohol consumption on the risk of Parkinson’s disease (PD).MethodsNational Health Insurance Service (NHIS) database between January 2009 to December 2011 was analyzed. A total of 3,931,741 patients were included. Study participants were followed up for the incidence of PD until December 2017.ResultsCompared to the sustained non-smokers, sustained light smokers (adjusted hazard ratio [aHR] 0.80, 95% confidence interval [CI] 0.75–0.85), sustained moderate smokers (aHR 0.54, 95% CI 0.47–0.61), and sustained heavy smokers (aHR 0.49, 95% CI 0.44–0.55) had a lower risk of PD. Compared to those who sustained non-drinking, sustained light drinkers (aHR 0.85 95% CI 0.89–0.91), sustained moderate drinkers (aHR 0.68, 95% CI 0.60–0.78), and sustained heavy drinkers (aHR 0.77, 95% CI 0.68–0.87) showed decreased risk of PD. Among non-drinkers, those who started drinking to a light level were at decreased risk of PD (aHR 0.84, 95% CI 0.77–0.91). Among non-smoking and non-drinking participants, those who initiated smoking only (aHR 0.78, 95% CI 0.70–0.86), drinking only (aHR 0.77, 95% CI 0.68–0.87), and both smoking and drinking (aHR 0.69, 95% CI 0.58–0.82) showed decreased risk of PD.ConclusionSmoking is associated with decreased risk of PD with a dose–response relationship. Alcohol consumption at a light level may also be associated with decreased risk of PD. Further studies are warranted to find the possible mechanisms for the protective effects of smoking and drinking on PD, which may present insights into the etiology of PD.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1223310/fullcigarette smokingalcohol consumptionParkinson’s diseaseAsianicotine |
| spellingShingle | Se Young Jung Se Young Jung Sohyun Chun Eun Bin Cho Kyungdo Han Juhwan Yoo Yohwan Yeo Jung Eun Yoo Su Min Jeong Ju-Hong Min Ju-Hong Min Ju-Hong Min Dong Wook Shin Dong Wook Shin Dong Wook Shin Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease Frontiers in Aging Neuroscience cigarette smoking alcohol consumption Parkinson’s disease Asia nicotine |
| title | Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease |
| title_full | Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease |
| title_fullStr | Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease |
| title_full_unstemmed | Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease |
| title_short | Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease |
| title_sort | changes in smoking alcohol consumption and the risk of parkinson s disease |
| topic | cigarette smoking alcohol consumption Parkinson’s disease Asia nicotine |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1223310/full |
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