Role of Serotonin Transporter in Eye Development of <i>Drosophila</i> <i>melanogaster</i>
Serotonin transporter (SerT) in the brain is an important neurotransmitter transporter involved in mental health. However, its role in peripheral organs is poorly understood. In this study, we investigated the function of SerT in the development of the compound eye in <i>Drosophila melanogaste...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/11/4086 |
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| author | Tuan L. A. Pham Tran Duy Binh Guanchen Liu Thanh Q. C. Nguyen Yen D. H. Nguyen Ritsuko Sahashi Tran Thanh Men Kaeko Kamei |
| author_facet | Tuan L. A. Pham Tran Duy Binh Guanchen Liu Thanh Q. C. Nguyen Yen D. H. Nguyen Ritsuko Sahashi Tran Thanh Men Kaeko Kamei |
| author_sort | Tuan L. A. Pham |
| collection | DOAJ |
| description | Serotonin transporter (SerT) in the brain is an important neurotransmitter transporter involved in mental health. However, its role in peripheral organs is poorly understood. In this study, we investigated the function of SerT in the development of the compound eye in <i>Drosophila melanogaster</i>. We found that SerT knockdown led to excessive cell death and an increased number of cells in S-phase in the posterior eye imaginal disc. Furthermore, the knockdown of <i>SerT</i> in the eye disc suppressed the activation of Akt, and the introduction of <i>PI3K</i> effectively rescued this phenotype. These results suggested that SerT plays a role in the healthy eye development of <i>D.</i> <i>melanogaster</i> by controlling cell death through the regulation of the PI3K/Akt pathway. |
| first_indexed | 2024-03-10T19:19:25Z |
| format | Article |
| id | doaj.art-ef0061aca6804410ba4043905190430e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:19:25Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ef0061aca6804410ba4043905190430e2023-11-20T03:09:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-06-012111408610.3390/ijms21114086Role of Serotonin Transporter in Eye Development of <i>Drosophila</i> <i>melanogaster</i>Tuan L. A. Pham0Tran Duy Binh1Guanchen Liu2Thanh Q. C. Nguyen3Yen D. H. Nguyen4Ritsuko Sahashi5Tran Thanh Men6Kaeko Kamei7Department of Functional Chemistry, Kyoto Institute of Technology, Kyoto 606-8585, JapanDepartment of Functional Chemistry, Kyoto Institute of Technology, Kyoto 606-8585, JapanDepartment of Functional Chemistry, Kyoto Institute of Technology, Kyoto 606-8585, JapanDepartment of Functional Chemistry, Kyoto Institute of Technology, Kyoto 606-8585, JapanDepartment of Functional Chemistry, Kyoto Institute of Technology, Kyoto 606-8585, JapanDepartment of Functional Chemistry, Kyoto Institute of Technology, Kyoto 606-8585, JapanDepartment of Biology, Cantho University, Cantho 900000, VietnamDepartment of Functional Chemistry, Kyoto Institute of Technology, Kyoto 606-8585, JapanSerotonin transporter (SerT) in the brain is an important neurotransmitter transporter involved in mental health. However, its role in peripheral organs is poorly understood. In this study, we investigated the function of SerT in the development of the compound eye in <i>Drosophila melanogaster</i>. We found that SerT knockdown led to excessive cell death and an increased number of cells in S-phase in the posterior eye imaginal disc. Furthermore, the knockdown of <i>SerT</i> in the eye disc suppressed the activation of Akt, and the introduction of <i>PI3K</i> effectively rescued this phenotype. These results suggested that SerT plays a role in the healthy eye development of <i>D.</i> <i>melanogaster</i> by controlling cell death through the regulation of the PI3K/Akt pathway.https://www.mdpi.com/1422-0067/21/11/4086<i>Drosophila</i>serotonin transportereye developmentcell deathPI3K/Akt pathway |
| spellingShingle | Tuan L. A. Pham Tran Duy Binh Guanchen Liu Thanh Q. C. Nguyen Yen D. H. Nguyen Ritsuko Sahashi Tran Thanh Men Kaeko Kamei Role of Serotonin Transporter in Eye Development of <i>Drosophila</i> <i>melanogaster</i> International Journal of Molecular Sciences <i>Drosophila</i> serotonin transporter eye development cell death PI3K/Akt pathway |
| title | Role of Serotonin Transporter in Eye Development of <i>Drosophila</i> <i>melanogaster</i> |
| title_full | Role of Serotonin Transporter in Eye Development of <i>Drosophila</i> <i>melanogaster</i> |
| title_fullStr | Role of Serotonin Transporter in Eye Development of <i>Drosophila</i> <i>melanogaster</i> |
| title_full_unstemmed | Role of Serotonin Transporter in Eye Development of <i>Drosophila</i> <i>melanogaster</i> |
| title_short | Role of Serotonin Transporter in Eye Development of <i>Drosophila</i> <i>melanogaster</i> |
| title_sort | role of serotonin transporter in eye development of i drosophila i i melanogaster i |
| topic | <i>Drosophila</i> serotonin transporter eye development cell death PI3K/Akt pathway |
| url | https://www.mdpi.com/1422-0067/21/11/4086 |
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