GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer

GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer

Epigenetic control of gene expression is a major determinant of tumor phenotype and has been found to influence sensitivity to individual chemotherapeutic agents. Glutathione peroxidase 3 (GPX3, plasma glutathione peroxidase) is a key component of cellular antioxidant regulation and its gene has bee...

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Bibliographic Details
Main Authors: Lorraine Pelosof, Sashidhar Yerram, Todd Armstrong, Nina Chu, Ludmila Danilova, Breann Yanagisawa, Manuel Hidalgo, Nilofer Azad, James G. Herman
Format: Article
Language:English
Published: Taylor & Francis Group 2017-07-01
Series:Epigenetics
Subjects:
cisplatin
colorectal cancer
gpx3
methylation
oxaliplatin
Online Access:http://dx.doi.org/10.1080/15592294.2016.1265711

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