UTILIZATION OF BROMINATION REACTION FOR THE SPECTROPHOTOMETRIC ASSAY OF DOMPERIDONE IN PHARMACEUTICALS
Three simple and sensitive spectrophotometric methods are described for the determination of domperidone (DOM) in bulk drug and in dosage forms using bromate-bromide mixture as brominating agent in acid medium and three dyes, meta-cresol purple (MCP), amaranth (AMR) and erioglaucine (EGC). The metho...
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| Format: | Article |
| Language: | English |
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Association of the Chemical Engineers of Serbia
2011-03-01
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| Series: | Chemical Industry and Chemical Engineering Quarterly |
| Subjects: | |
| Online Access: | http://www.ache.org.rs/CICEQ/2011/No1/CICEQ_Vol17_%20No1_pp81-89_Jan-Mar_2011.pdf |
| _version_ | 1818362310764265472 |
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| author | O. ZENITA DEVI K. BASAVAIAH K.B. VINAY |
| author_facet | O. ZENITA DEVI K. BASAVAIAH K.B. VINAY |
| author_sort | O. ZENITA DEVI |
| collection | DOAJ |
| description | Three simple and sensitive spectrophotometric methods are described for the determination of domperidone (DOM) in bulk drug and in dosage forms using bromate-bromide mixture as brominating agent in acid medium and three dyes, meta-cresol purple (MCP), amaranth (AMR) and erioglaucine (EGC). The methods involve the addition of a known excess of bromate-bromide mixture to an acidified solution of DOM followed by the determination of the residual bromine by reacting with a fixed amount of either MCP dye and measuring the absorbance at 530 nm (method A) or AMR dye and measuring the absorbance at 520 nm (method B) or EGC dye and measuring the absorbance at 630 nm (method C). Beer’s law is obeyed over the concentration ranges, 0.63–10.0, 0.25-4.0 and 0.13-2.0 µg mL-1 for method A, B and C, respectively. The ap¬parent molar absorptivities are calculated to be 3.751x104, 6.604x104 and 1.987x105 L mol-1cm-1 for method A, B and C, respectively, and the corresponding sandell sensitivity values are 0.011, 0.006 and 0.002 μg cm-2. The limit of detection and the limit of quantification are also reported for all the three methods. No interference was observed from common additives found in pharmaceutical preparations. Statistical comparisons of the results with those of the reference method showed excellent agreement, and indicated no significant difference in accuracy and precision. The accuracy and reliability of the methods were further ascertained by performing recovery tests via standardaddition technique. |
| first_indexed | 2024-12-13T21:30:33Z |
| format | Article |
| id | doaj.art-ef053ddc1dc24468976c2fc61d43f58d |
| institution | Directory Open Access Journal |
| issn | 1451-9372 |
| language | English |
| last_indexed | 2024-12-13T21:30:33Z |
| publishDate | 2011-03-01 |
| publisher | Association of the Chemical Engineers of Serbia |
| record_format | Article |
| series | Chemical Industry and Chemical Engineering Quarterly |
| spelling | doaj.art-ef053ddc1dc24468976c2fc61d43f58d2022-12-21T23:30:50ZengAssociation of the Chemical Engineers of SerbiaChemical Industry and Chemical Engineering Quarterly1451-93722011-03-011718189UTILIZATION OF BROMINATION REACTION FOR THE SPECTROPHOTOMETRIC ASSAY OF DOMPERIDONE IN PHARMACEUTICALSO. ZENITA DEVIK. BASAVAIAHK.B. VINAYThree simple and sensitive spectrophotometric methods are described for the determination of domperidone (DOM) in bulk drug and in dosage forms using bromate-bromide mixture as brominating agent in acid medium and three dyes, meta-cresol purple (MCP), amaranth (AMR) and erioglaucine (EGC). The methods involve the addition of a known excess of bromate-bromide mixture to an acidified solution of DOM followed by the determination of the residual bromine by reacting with a fixed amount of either MCP dye and measuring the absorbance at 530 nm (method A) or AMR dye and measuring the absorbance at 520 nm (method B) or EGC dye and measuring the absorbance at 630 nm (method C). Beer’s law is obeyed over the concentration ranges, 0.63–10.0, 0.25-4.0 and 0.13-2.0 µg mL-1 for method A, B and C, respectively. The ap¬parent molar absorptivities are calculated to be 3.751x104, 6.604x104 and 1.987x105 L mol-1cm-1 for method A, B and C, respectively, and the corresponding sandell sensitivity values are 0.011, 0.006 and 0.002 μg cm-2. The limit of detection and the limit of quantification are also reported for all the three methods. No interference was observed from common additives found in pharmaceutical preparations. Statistical comparisons of the results with those of the reference method showed excellent agreement, and indicated no significant difference in accuracy and precision. The accuracy and reliability of the methods were further ascertained by performing recovery tests via standardaddition technique.http://www.ache.org.rs/CICEQ/2011/No1/CICEQ_Vol17_%20No1_pp81-89_Jan-Mar_2011.pdfdomperidonassayspectrophotometrybromate-bromidedyestablets. |
| spellingShingle | O. ZENITA DEVI K. BASAVAIAH K.B. VINAY UTILIZATION OF BROMINATION REACTION FOR THE SPECTROPHOTOMETRIC ASSAY OF DOMPERIDONE IN PHARMACEUTICALS Chemical Industry and Chemical Engineering Quarterly domperidon assay spectrophotometry bromate-bromide dyes tablets. |
| title | UTILIZATION OF BROMINATION REACTION FOR THE SPECTROPHOTOMETRIC ASSAY OF DOMPERIDONE IN PHARMACEUTICALS |
| title_full | UTILIZATION OF BROMINATION REACTION FOR THE SPECTROPHOTOMETRIC ASSAY OF DOMPERIDONE IN PHARMACEUTICALS |
| title_fullStr | UTILIZATION OF BROMINATION REACTION FOR THE SPECTROPHOTOMETRIC ASSAY OF DOMPERIDONE IN PHARMACEUTICALS |
| title_full_unstemmed | UTILIZATION OF BROMINATION REACTION FOR THE SPECTROPHOTOMETRIC ASSAY OF DOMPERIDONE IN PHARMACEUTICALS |
| title_short | UTILIZATION OF BROMINATION REACTION FOR THE SPECTROPHOTOMETRIC ASSAY OF DOMPERIDONE IN PHARMACEUTICALS |
| title_sort | utilization of bromination reaction for the spectrophotometric assay of domperidone in pharmaceuticals |
| topic | domperidon assay spectrophotometry bromate-bromide dyes tablets. |
| url | http://www.ache.org.rs/CICEQ/2011/No1/CICEQ_Vol17_%20No1_pp81-89_Jan-Mar_2011.pdf |
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