Neuroprotective effects of crocin and crocin-loaded niosomes against the paraquat-induced oxidative brain damage in rats
Paraquat (PQ) is a nonselective herbicide that induces oxidative reactions and multiple-organ failure on exposure. Crocin, a carotenoid obtained from saffron, has demonstrated many therapeutic effects against neural conditions because of its antioxidant properties. In this study, 30 male Wistar rats...
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-09-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2022-0468 |
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| author | Daneshvar Afsoon Jouzdani Ali Fathi Firozian Farzin Asl Sara Soleimani Mohammadi Mojdeh Ranjbar Akram |
| author_facet | Daneshvar Afsoon Jouzdani Ali Fathi Firozian Farzin Asl Sara Soleimani Mohammadi Mojdeh Ranjbar Akram |
| author_sort | Daneshvar Afsoon |
| collection | DOAJ |
| description | Paraquat (PQ) is a nonselective herbicide that induces oxidative reactions and multiple-organ failure on exposure. Crocin, a carotenoid obtained from saffron, has demonstrated many therapeutic effects against neural conditions because of its antioxidant properties. In this study, 30 male Wistar rats were divided into 6 groups to evaluate the protective effects of crocin and crocin-loaded niosomes (NC) against PQ in the brain. The levels of total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol groups (TTG), superoxide dismutase (SOD), and catalase (CAT) activity were measured as the markers of redox status. Histopathological changes in the CA1 region of the hippocampus were evaluated by cresyl violet staining. Results indicated that both crocin and NC were able to attenuate the adverse effects of PQ at the histopathological level, which was following the changes in LPO (P < 0.0001), TAC (P < 0.01), and TTG (P < 0.05) level. The activity of CAT (P < 0.01) and SOD (P < 0.01) could be restored either by crocin or NC. Also, results indicated that nanoformulation of crocin in niosomes appears to be more promising. In conclusion, both crocin and NC showed favourable effects of PQ in the brain of rats, and were determined to be excellent agents to prevent acute toxicities of PQ. Furthermore, these two compounds can be known to provide neuroprotection. |
| first_indexed | 2024-04-12T12:12:57Z |
| format | Article |
| id | doaj.art-ef07831fc4e94202be8e41ff5d362134 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-04-12T12:12:57Z |
| publishDate | 2022-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-ef07831fc4e94202be8e41ff5d3621342022-12-22T03:33:32ZengDe GruyterOpen Life Sciences2391-54122022-09-011711174118110.1515/biol-2022-0468Neuroprotective effects of crocin and crocin-loaded niosomes against the paraquat-induced oxidative brain damage in ratsDaneshvar Afsoon0Jouzdani Ali Fathi1Firozian Farzin2Asl Sara Soleimani3Mohammadi Mojdeh4Ranjbar Akram5Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, 6517838678, IranDepartment of Neuroscience, Neuroscience and Artificial Intelligence Research Group (NAIRG), Student Research Committee, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Pharmaceutics, Faculty of Pharmacy, Hamadan University of Medical Science, Hamadan, IranDepartment of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, 6517838678, IranDepartment of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, 6517838678, IranParaquat (PQ) is a nonselective herbicide that induces oxidative reactions and multiple-organ failure on exposure. Crocin, a carotenoid obtained from saffron, has demonstrated many therapeutic effects against neural conditions because of its antioxidant properties. In this study, 30 male Wistar rats were divided into 6 groups to evaluate the protective effects of crocin and crocin-loaded niosomes (NC) against PQ in the brain. The levels of total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol groups (TTG), superoxide dismutase (SOD), and catalase (CAT) activity were measured as the markers of redox status. Histopathological changes in the CA1 region of the hippocampus were evaluated by cresyl violet staining. Results indicated that both crocin and NC were able to attenuate the adverse effects of PQ at the histopathological level, which was following the changes in LPO (P < 0.0001), TAC (P < 0.01), and TTG (P < 0.05) level. The activity of CAT (P < 0.01) and SOD (P < 0.01) could be restored either by crocin or NC. Also, results indicated that nanoformulation of crocin in niosomes appears to be more promising. In conclusion, both crocin and NC showed favourable effects of PQ in the brain of rats, and were determined to be excellent agents to prevent acute toxicities of PQ. Furthermore, these two compounds can be known to provide neuroprotection.https://doi.org/10.1515/biol-2022-0468braincrocin-loaded niosomesoxidative stressparaquatrats |
| spellingShingle | Daneshvar Afsoon Jouzdani Ali Fathi Firozian Farzin Asl Sara Soleimani Mohammadi Mojdeh Ranjbar Akram Neuroprotective effects of crocin and crocin-loaded niosomes against the paraquat-induced oxidative brain damage in rats Open Life Sciences brain crocin-loaded niosomes oxidative stress paraquat rats |
| title | Neuroprotective effects of crocin and crocin-loaded niosomes against the paraquat-induced oxidative brain damage in rats |
| title_full | Neuroprotective effects of crocin and crocin-loaded niosomes against the paraquat-induced oxidative brain damage in rats |
| title_fullStr | Neuroprotective effects of crocin and crocin-loaded niosomes against the paraquat-induced oxidative brain damage in rats |
| title_full_unstemmed | Neuroprotective effects of crocin and crocin-loaded niosomes against the paraquat-induced oxidative brain damage in rats |
| title_short | Neuroprotective effects of crocin and crocin-loaded niosomes against the paraquat-induced oxidative brain damage in rats |
| title_sort | neuroprotective effects of crocin and crocin loaded niosomes against the paraquat induced oxidative brain damage in rats |
| topic | brain crocin-loaded niosomes oxidative stress paraquat rats |
| url | https://doi.org/10.1515/biol-2022-0468 |
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