Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes
Systemic toxicity and severe side effects are commonly associated with anticancer chemotherapies. New strategies based on enhanced drug selectivity and targeted delivery to cancer cells while leaving healthy tissue undamaged can reduce the global patient burden. Herein, we report the design, synthes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/5/480 |
| _version_ | 1797567119521480704 |
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| author | Joachim Delasoie Philippe Schiel Sandra Vojnovic Jasmina Nikodinovic-Runic Fabio Zobi |
| author_facet | Joachim Delasoie Philippe Schiel Sandra Vojnovic Jasmina Nikodinovic-Runic Fabio Zobi |
| author_sort | Joachim Delasoie |
| collection | DOAJ |
| description | Systemic toxicity and severe side effects are commonly associated with anticancer chemotherapies. New strategies based on enhanced drug selectivity and targeted delivery to cancer cells while leaving healthy tissue undamaged can reduce the global patient burden. Herein, we report the design, synthesis and characterization of a bio-inspired hybrid multifunctional drug delivery system based on diatom microalgae. The microalgae’s surface was chemically functionalized with hybrid vitamin B<sub>12</sub>-photoactivatable molecules and the materials further loaded with highly active rhenium(I) tricarbonyl anticancer complexes. The constructs showed enhanced adherence to colorectal cancer (CRC) cells and slow release of the chemotherapeutic drugs. The overall toxicity of the hybrid multifunctional drug delivery system was further enhanced by photoactivation of the microalgae surface. Depending on the construct and anticancer drug, a 2-fold increase in the cytotoxic efficacy of the drug was observed upon light irradiation. The use of this targeted drug delivery strategy, together with selective spatial–temporal light activation, may lead to lower effective concentration of anticancer drugs, thereby reducing medication doses, possible side effects and overall burden for the patient. |
| first_indexed | 2024-03-10T19:37:08Z |
| format | Article |
| id | doaj.art-ef0ae45fdee14b488617613820c6551f |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T19:37:08Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-ef0ae45fdee14b488617613820c6551f2023-11-20T01:37:03ZengMDPI AGPharmaceutics1999-49232020-05-0112548010.3390/pharmaceutics12050480Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer ComplexesJoachim Delasoie0Philippe Schiel1Sandra Vojnovic2Jasmina Nikodinovic-Runic3Fabio Zobi4Department of Chemistry, Fribourg University, Chemin du Musée 9, 1700 Fribourg, SwitzerlandDepartment of Chemistry, Fribourg University, Chemin du Musée 9, 1700 Fribourg, SwitzerlandInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, SerbiaInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, SerbiaDepartment of Chemistry, Fribourg University, Chemin du Musée 9, 1700 Fribourg, SwitzerlandSystemic toxicity and severe side effects are commonly associated with anticancer chemotherapies. New strategies based on enhanced drug selectivity and targeted delivery to cancer cells while leaving healthy tissue undamaged can reduce the global patient burden. Herein, we report the design, synthesis and characterization of a bio-inspired hybrid multifunctional drug delivery system based on diatom microalgae. The microalgae’s surface was chemically functionalized with hybrid vitamin B<sub>12</sub>-photoactivatable molecules and the materials further loaded with highly active rhenium(I) tricarbonyl anticancer complexes. The constructs showed enhanced adherence to colorectal cancer (CRC) cells and slow release of the chemotherapeutic drugs. The overall toxicity of the hybrid multifunctional drug delivery system was further enhanced by photoactivation of the microalgae surface. Depending on the construct and anticancer drug, a 2-fold increase in the cytotoxic efficacy of the drug was observed upon light irradiation. The use of this targeted drug delivery strategy, together with selective spatial–temporal light activation, may lead to lower effective concentration of anticancer drugs, thereby reducing medication doses, possible side effects and overall burden for the patient.https://www.mdpi.com/1999-4923/12/5/480diatomsdrug delivery systemHCT-116porphyrinvitamin B<sub>12</sub>carbon monoxide releasing molecule |
| spellingShingle | Joachim Delasoie Philippe Schiel Sandra Vojnovic Jasmina Nikodinovic-Runic Fabio Zobi Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes Pharmaceutics diatoms drug delivery system HCT-116 porphyrin vitamin B<sub>12</sub> carbon monoxide releasing molecule |
| title | Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes |
| title_full | Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes |
| title_fullStr | Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes |
| title_full_unstemmed | Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes |
| title_short | Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes |
| title_sort | photoactivatable surface functionalized diatom microalgae for colorectal cancer targeted delivery and enhanced cytotoxicity of anticancer complexes |
| topic | diatoms drug delivery system HCT-116 porphyrin vitamin B<sub>12</sub> carbon monoxide releasing molecule |
| url | https://www.mdpi.com/1999-4923/12/5/480 |
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