The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks
The eukaryotic nucleus is continuously being exposed to endogenous and exogenous sources that cause DNA breaks, whose faithful repair requires the activity of dedicated nuclear machineries. DNA is packaged into a variety of chromatin domains, each characterized by specific molecular properties that...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/9/1415 |
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| author | Apfrida Kendek Marieke R. Wensveen Aniek Janssen |
| author_facet | Apfrida Kendek Marieke R. Wensveen Aniek Janssen |
| author_sort | Apfrida Kendek |
| collection | DOAJ |
| description | The eukaryotic nucleus is continuously being exposed to endogenous and exogenous sources that cause DNA breaks, whose faithful repair requires the activity of dedicated nuclear machineries. DNA is packaged into a variety of chromatin domains, each characterized by specific molecular properties that regulate gene expression and help maintain nuclear structure. These different chromatin environments each demand a tailored response to DNA damage. Silenced chromatin domains in particular present a major challenge to the cell’s DNA repair machinery due to their specific biophysical properties and distinct, often repetitive, DNA content. To this end, we here discuss the interplay between silenced chromatin domains and DNA damage repair, specifically double-strand breaks, and how these processes help maintain genome stability. |
| first_indexed | 2024-03-10T07:39:10Z |
| format | Article |
| id | doaj.art-ef0b9c3ec98b4f7c95e0ff79ccc4b19e |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T07:39:10Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-ef0b9c3ec98b4f7c95e0ff79ccc4b19e2023-11-22T13:14:45ZengMDPI AGGenes2073-44252021-09-01129141510.3390/genes12091415The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand BreaksApfrida Kendek0Marieke R. Wensveen1Aniek Janssen2Center for Molecular Medicine, Section Molecular Cancer Research, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The NetherlandsCenter for Molecular Medicine, Section Molecular Cancer Research, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The NetherlandsCenter for Molecular Medicine, Section Molecular Cancer Research, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The NetherlandsThe eukaryotic nucleus is continuously being exposed to endogenous and exogenous sources that cause DNA breaks, whose faithful repair requires the activity of dedicated nuclear machineries. DNA is packaged into a variety of chromatin domains, each characterized by specific molecular properties that regulate gene expression and help maintain nuclear structure. These different chromatin environments each demand a tailored response to DNA damage. Silenced chromatin domains in particular present a major challenge to the cell’s DNA repair machinery due to their specific biophysical properties and distinct, often repetitive, DNA content. To this end, we here discuss the interplay between silenced chromatin domains and DNA damage repair, specifically double-strand breaks, and how these processes help maintain genome stability.https://www.mdpi.com/2073-4425/12/9/1415constitutive heterochromatinfacultative heterochromatinDNA-damage repairdouble-strand breaks |
| spellingShingle | Apfrida Kendek Marieke R. Wensveen Aniek Janssen The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks Genes constitutive heterochromatin facultative heterochromatin DNA-damage repair double-strand breaks |
| title | The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks |
| title_full | The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks |
| title_fullStr | The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks |
| title_full_unstemmed | The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks |
| title_short | The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks |
| title_sort | sound of silence how silenced chromatin orchestrates the repair of double strand breaks |
| topic | constitutive heterochromatin facultative heterochromatin DNA-damage repair double-strand breaks |
| url | https://www.mdpi.com/2073-4425/12/9/1415 |
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