Shrinking Weibel‐Palade bodies prevents high platelet recruitment in assays using thrombotic thrombocytopenic purpura plasma

Shrinking Weibel‐Palade bodies prevents high platelet recruitment in assays using thrombotic thrombocytopenic purpura plasma

Abstract Background Thrombotic thrombocytopenic purpura (TTP), caused by a genetic or autoimmune‐driven lack of ADAMTS‐13 activity, leads to high levels of the ultra‐large von Willebrand factor (VWF) multimers produced by endothelial cells, causing excess platelet recruitment into forming thrombi, o...

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Bibliographic Details
Main Authors: Francesca Patella, Chiara Vendramin, Oscar Charles, Marie A. Scully, Daniel F. Cutler
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
blood platelets
fluvastatin
human
thrombotic thrombocytopenic purpura
von Willebrand factor
Weibel‐Palade bodies
Online Access:https://doi.org/10.1002/rth2.12626

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