The Chimeric Chaoyang-Zika Vaccine Candidate Is Safe and Protective in Mice
Zika virus (ZIKV) is an emerging flavivirus that causes congenital syndromes including microcephaly and fetal demise in pregnant women. No commercial vaccines against ZIKV are currently available. We previously generated a chimeric ZIKV (ChinZIKV) based on the Chaoyang virus (CYV) by replacing the p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/12/2/215 |
| _version_ | 1797296906690363392 |
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| author | Hao-Long Dong Zhi-Li Chen Mei-Juan He Jia-Zhen Cui Hao Cheng Qing-Yang Wang Xiang-Hua Xiong Gang Liu Hui-Peng Chen |
| author_facet | Hao-Long Dong Zhi-Li Chen Mei-Juan He Jia-Zhen Cui Hao Cheng Qing-Yang Wang Xiang-Hua Xiong Gang Liu Hui-Peng Chen |
| author_sort | Hao-Long Dong |
| collection | DOAJ |
| description | Zika virus (ZIKV) is an emerging flavivirus that causes congenital syndromes including microcephaly and fetal demise in pregnant women. No commercial vaccines against ZIKV are currently available. We previously generated a chimeric ZIKV (ChinZIKV) based on the Chaoyang virus (CYV) by replacing the prME protein of CYV with that of a contemporary ZIKV strain GZ01. Herein, we evaluated this vaccine candidate in a mouse model and showed that ChinZIKV was totally safe in both adult and suckling immunodeficient mice. No viral RNA was detected in the serum of mice inoculated with ChinZIKV. All of the mice inoculated with ChinZIKV survived, while mice inoculated with ZIKV succumbed to infection in 8 days. A single dose of ChinZIKV partially protected mice against lethal ZIKV challenge. In contrast, all the control PBS-immunized mice succumbed to infection after ZIKV challenge. Our results warrant further development of ChinZIKV as a vaccine candidate in clinical trials. |
| first_indexed | 2024-03-07T22:11:35Z |
| format | Article |
| id | doaj.art-ef0cc7d10ba545c6910e3a88fb562376 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-07T22:11:35Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-ef0cc7d10ba545c6910e3a88fb5623762024-02-23T15:37:13ZengMDPI AGVaccines2076-393X2024-02-0112221510.3390/vaccines12020215The Chimeric Chaoyang-Zika Vaccine Candidate Is Safe and Protective in MiceHao-Long Dong0Zhi-Li Chen1Mei-Juan He2Jia-Zhen Cui3Hao Cheng4Qing-Yang Wang5Xiang-Hua Xiong6Gang Liu7Hui-Peng Chen8Academy of Military Medical Sciences, Beijing 100071, ChinaAcademy of Military Medical Sciences, Beijing 100071, ChinaAcademy of Military Medical Sciences, Beijing 100071, ChinaAcademy of Military Medical Sciences, Beijing 100071, ChinaAcademy of Military Medical Sciences, Beijing 100071, ChinaAcademy of Military Medical Sciences, Beijing 100071, ChinaAcademy of Military Medical Sciences, Beijing 100071, ChinaAcademy of Military Medical Sciences, Beijing 100071, ChinaAcademy of Military Medical Sciences, Beijing 100071, ChinaZika virus (ZIKV) is an emerging flavivirus that causes congenital syndromes including microcephaly and fetal demise in pregnant women. No commercial vaccines against ZIKV are currently available. We previously generated a chimeric ZIKV (ChinZIKV) based on the Chaoyang virus (CYV) by replacing the prME protein of CYV with that of a contemporary ZIKV strain GZ01. Herein, we evaluated this vaccine candidate in a mouse model and showed that ChinZIKV was totally safe in both adult and suckling immunodeficient mice. No viral RNA was detected in the serum of mice inoculated with ChinZIKV. All of the mice inoculated with ChinZIKV survived, while mice inoculated with ZIKV succumbed to infection in 8 days. A single dose of ChinZIKV partially protected mice against lethal ZIKV challenge. In contrast, all the control PBS-immunized mice succumbed to infection after ZIKV challenge. Our results warrant further development of ChinZIKV as a vaccine candidate in clinical trials.https://www.mdpi.com/2076-393X/12/2/215flavivirusZika virusvaccine candidatemouseChaoyang virus |
| spellingShingle | Hao-Long Dong Zhi-Li Chen Mei-Juan He Jia-Zhen Cui Hao Cheng Qing-Yang Wang Xiang-Hua Xiong Gang Liu Hui-Peng Chen The Chimeric Chaoyang-Zika Vaccine Candidate Is Safe and Protective in Mice Vaccines flavivirus Zika virus vaccine candidate mouse Chaoyang virus |
| title | The Chimeric Chaoyang-Zika Vaccine Candidate Is Safe and Protective in Mice |
| title_full | The Chimeric Chaoyang-Zika Vaccine Candidate Is Safe and Protective in Mice |
| title_fullStr | The Chimeric Chaoyang-Zika Vaccine Candidate Is Safe and Protective in Mice |
| title_full_unstemmed | The Chimeric Chaoyang-Zika Vaccine Candidate Is Safe and Protective in Mice |
| title_short | The Chimeric Chaoyang-Zika Vaccine Candidate Is Safe and Protective in Mice |
| title_sort | chimeric chaoyang zika vaccine candidate is safe and protective in mice |
| topic | flavivirus Zika virus vaccine candidate mouse Chaoyang virus |
| url | https://www.mdpi.com/2076-393X/12/2/215 |
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