Target search in the CRISPR/Cas9 system: facilitated diffusion with target cues

Target search in the CRISPR/Cas9 system: facilitated diffusion with target cues

We study how Cas9, a central component of the CRISPR/Cas9 system, searches for a target sequence on the DNA. We propose a model that includes as key ingredients 3D diffusion, 1D sliding along the DNA, and the effect of short binding sequences preceding the target (protospacer adjacent motifs—PAMs)....

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Bibliographic Details
Main Authors: Qiao Lu (路桥), Simone Pigolotti
Format: Article
Language:English
Published: IOP Publishing 2024-01-01
Series:New Journal of Physics
Subjects:
target
search
CRISPR
Cas9
facilitated
diffusion
Online Access:https://doi.org/10.1088/1367-2630/ad3841

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