Cardiovascular and renal burdens among patients with MAFLD and NAFLD in China
Background/PurposeMetabolic associated fatty liver disease (MAFLD) was proposed as a new definition to put emphasis on the metabolic aspects of nonalcoholic fatty liver disease (NAFLD). We aim to compare the cardiovascular and renal burden between MAFLD and NAFLD patients.Methods12183 participants w...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.968766/full |
| _version_ | 1798039753602367488 |
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| author | Yuying Wang Yuetian Yu Haojie Zhang Chi Chen Heng Wan Yi Chen Fangzhen Xia Shiyan Yu Ningjian Wang Lin Ye Yingli Lu |
| author_facet | Yuying Wang Yuetian Yu Haojie Zhang Chi Chen Heng Wan Yi Chen Fangzhen Xia Shiyan Yu Ningjian Wang Lin Ye Yingli Lu |
| author_sort | Yuying Wang |
| collection | DOAJ |
| description | Background/PurposeMetabolic associated fatty liver disease (MAFLD) was proposed as a new definition to put emphasis on the metabolic aspects of nonalcoholic fatty liver disease (NAFLD). We aim to compare the cardiovascular and renal burden between MAFLD and NAFLD patients.Methods12183 participants were enrolled in East China. The cardiovascular burden (Framingham risk score and previous cardiovascular diseases (CVD)) and renal burden (eGFR and chronic kidney disease (CKD)) were measured.ResultsThe risk of hypertension, dyslipidemia, diabetes, overweight/obesity, and central obesity of MAFLD patients were higher than those of NAFLD. Patients with MAFLD have a similar or higher beta coefficients in Framingham risk score [beta (95%CI): male 0.062 (0.055,0.069) vs 0.041 (0.033,0.048); female 0.014 (0.012,0.016) vs 0.012 (0.01,0.014)], and higher odds ratio in previous CVD [odds ratio (95%CI): male 1.50 (1.22,1.85) vs 1.35 (1.1,1.66); female 1.58 (1.33,1.87) vs 1.45 (1.22,1.72)], compared with those with NAFLD. However, compared with males with MAFLD, the odds ratio of CKD was higher in those with NAFLD [eGFR: -2.731 (-3.422, -2.041) vs-3.578 (-4.268, -2.887). CKD: 1.44 (1.05,1.96) vs 1.56 (1.14,2.12)]. In female, CKD was only marginally associated with NAFLD [0.8 (0.62,1.02), P=0.075], but not MAFLD [0.87 (0.68,1.11), P=0.268].ConclusionsPatients with MAFLD have a similar or higher risk of future and previous CVD compared with those with NAFLD, but the risk of CKD was higher in male with NAFLD. |
| first_indexed | 2024-04-11T21:58:06Z |
| format | Article |
| id | doaj.art-ef0f6aba9ea64de2884cfeab510c6a2f |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T21:58:06Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ef0f6aba9ea64de2884cfeab510c6a2f2022-12-22T04:01:03ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-09-011310.3389/fendo.2022.968766968766Cardiovascular and renal burdens among patients with MAFLD and NAFLD in ChinaYuying WangYuetian YuHaojie ZhangChi ChenHeng WanYi ChenFangzhen XiaShiyan YuNingjian WangLin YeYingli LuBackground/PurposeMetabolic associated fatty liver disease (MAFLD) was proposed as a new definition to put emphasis on the metabolic aspects of nonalcoholic fatty liver disease (NAFLD). We aim to compare the cardiovascular and renal burden between MAFLD and NAFLD patients.Methods12183 participants were enrolled in East China. The cardiovascular burden (Framingham risk score and previous cardiovascular diseases (CVD)) and renal burden (eGFR and chronic kidney disease (CKD)) were measured.ResultsThe risk of hypertension, dyslipidemia, diabetes, overweight/obesity, and central obesity of MAFLD patients were higher than those of NAFLD. Patients with MAFLD have a similar or higher beta coefficients in Framingham risk score [beta (95%CI): male 0.062 (0.055,0.069) vs 0.041 (0.033,0.048); female 0.014 (0.012,0.016) vs 0.012 (0.01,0.014)], and higher odds ratio in previous CVD [odds ratio (95%CI): male 1.50 (1.22,1.85) vs 1.35 (1.1,1.66); female 1.58 (1.33,1.87) vs 1.45 (1.22,1.72)], compared with those with NAFLD. However, compared with males with MAFLD, the odds ratio of CKD was higher in those with NAFLD [eGFR: -2.731 (-3.422, -2.041) vs-3.578 (-4.268, -2.887). CKD: 1.44 (1.05,1.96) vs 1.56 (1.14,2.12)]. In female, CKD was only marginally associated with NAFLD [0.8 (0.62,1.02), P=0.075], but not MAFLD [0.87 (0.68,1.11), P=0.268].ConclusionsPatients with MAFLD have a similar or higher risk of future and previous CVD compared with those with NAFLD, but the risk of CKD was higher in male with NAFLD.https://www.frontiersin.org/articles/10.3389/fendo.2022.968766/fullCVDCKDMAFLDNAFLDChina |
| spellingShingle | Yuying Wang Yuetian Yu Haojie Zhang Chi Chen Heng Wan Yi Chen Fangzhen Xia Shiyan Yu Ningjian Wang Lin Ye Yingli Lu Cardiovascular and renal burdens among patients with MAFLD and NAFLD in China Frontiers in Endocrinology CVD CKD MAFLD NAFLD China |
| title | Cardiovascular and renal burdens among patients with MAFLD and NAFLD in China |
| title_full | Cardiovascular and renal burdens among patients with MAFLD and NAFLD in China |
| title_fullStr | Cardiovascular and renal burdens among patients with MAFLD and NAFLD in China |
| title_full_unstemmed | Cardiovascular and renal burdens among patients with MAFLD and NAFLD in China |
| title_short | Cardiovascular and renal burdens among patients with MAFLD and NAFLD in China |
| title_sort | cardiovascular and renal burdens among patients with mafld and nafld in china |
| topic | CVD CKD MAFLD NAFLD China |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.968766/full |
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