Three-Phase-Lag Bio-Heat Transfer Model of Cardiac Ablation
Significant research efforts have been devoted in the past decades to accurately modelling the complex heat transfer phenomena within biological tissues. These modeling efforts and analysis have assisted in a better understanding of the intricacies of associated biological phenomena and factors that...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Fluids |
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| Online Access: | https://www.mdpi.com/2311-5521/7/5/180 |
| _version_ | 1797499937965998080 |
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| author | Sundeep Singh Paola Saccomandi Roderick Melnik |
| author_facet | Sundeep Singh Paola Saccomandi Roderick Melnik |
| author_sort | Sundeep Singh |
| collection | DOAJ |
| description | Significant research efforts have been devoted in the past decades to accurately modelling the complex heat transfer phenomena within biological tissues. These modeling efforts and analysis have assisted in a better understanding of the intricacies of associated biological phenomena and factors that affect the treatment outcomes of hyperthermic therapeutic procedures. In this contribution, we report a three-dimensional non-Fourier bio-heat transfer model of cardiac ablation that accounts for the three-phase-lags (TPL) in the heat propagation, viz., lags due to heat flux, temperature gradient, and thermal displacement gradient. Finite element-based COMSOL Multiphysics software has been utilized to predict the temperature distributions and ablation volumes. A comparative analysis has been conducted to report the variation in the treatment outcomes of cardiac ablation considering different bio-heat transfer models. The effect of variations in the magnitude of different phase lags has been systematically investigated. The fidelity and integrity of the developed model have been evaluated by comparing the results of the developed model with the analytical results of the recent studies available in the literature. This study demonstrates the importance of considering non-Fourier lags within biological tissue for predicting more accurately the characteristics important for the efficient application of thermal therapies. |
| first_indexed | 2024-03-10T03:54:39Z |
| format | Article |
| id | doaj.art-ef0fa88bad084c01b40b4fbdc935d268 |
| institution | Directory Open Access Journal |
| issn | 2311-5521 |
| language | English |
| last_indexed | 2024-03-10T03:54:39Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fluids |
| spelling | doaj.art-ef0fa88bad084c01b40b4fbdc935d2682023-11-23T10:58:11ZengMDPI AGFluids2311-55212022-05-017518010.3390/fluids7050180Three-Phase-Lag Bio-Heat Transfer Model of Cardiac AblationSundeep Singh0Paola Saccomandi1Roderick Melnik2Schulich School of Engineering, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, CanadaDepartment of Mechanical Engineering, Politecnico di Milano, 20156 Milan, ItalyMS2Discovery Interdisciplinary Research Institute, Wilfrid Laurier University, 75 University Avenue West, Waterloo, ON N2L 3C5, CanadaSignificant research efforts have been devoted in the past decades to accurately modelling the complex heat transfer phenomena within biological tissues. These modeling efforts and analysis have assisted in a better understanding of the intricacies of associated biological phenomena and factors that affect the treatment outcomes of hyperthermic therapeutic procedures. In this contribution, we report a three-dimensional non-Fourier bio-heat transfer model of cardiac ablation that accounts for the three-phase-lags (TPL) in the heat propagation, viz., lags due to heat flux, temperature gradient, and thermal displacement gradient. Finite element-based COMSOL Multiphysics software has been utilized to predict the temperature distributions and ablation volumes. A comparative analysis has been conducted to report the variation in the treatment outcomes of cardiac ablation considering different bio-heat transfer models. The effect of variations in the magnitude of different phase lags has been systematically investigated. The fidelity and integrity of the developed model have been evaluated by comparing the results of the developed model with the analytical results of the recent studies available in the literature. This study demonstrates the importance of considering non-Fourier lags within biological tissue for predicting more accurately the characteristics important for the efficient application of thermal therapies.https://www.mdpi.com/2311-5521/7/5/180hyperthermiacardiac ablationbio-heat transfernon-Fourier heat transferTPL modelnumerical simulations |
| spellingShingle | Sundeep Singh Paola Saccomandi Roderick Melnik Three-Phase-Lag Bio-Heat Transfer Model of Cardiac Ablation Fluids hyperthermia cardiac ablation bio-heat transfer non-Fourier heat transfer TPL model numerical simulations |
| title | Three-Phase-Lag Bio-Heat Transfer Model of Cardiac Ablation |
| title_full | Three-Phase-Lag Bio-Heat Transfer Model of Cardiac Ablation |
| title_fullStr | Three-Phase-Lag Bio-Heat Transfer Model of Cardiac Ablation |
| title_full_unstemmed | Three-Phase-Lag Bio-Heat Transfer Model of Cardiac Ablation |
| title_short | Three-Phase-Lag Bio-Heat Transfer Model of Cardiac Ablation |
| title_sort | three phase lag bio heat transfer model of cardiac ablation |
| topic | hyperthermia cardiac ablation bio-heat transfer non-Fourier heat transfer TPL model numerical simulations |
| url | https://www.mdpi.com/2311-5521/7/5/180 |
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