Nifedipine, captopril or sublingual nitroglycerin, which can reduce blood pressure the most?
BACKGROUND: Hypertension (HTN) is one of the most important problems in all parts of the world. Although the disease is usually asymptomatic, its diagnosis and treatment are easy. The aim of this study was to compare the effect of Nifedipine (Adalat®), Captopril and sublingual Nitroglycerin on reduc...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Vesnu Publications
2011-08-01
|
| Series: | ARYA Atherosclerosis |
| Online Access: | http://arya.mui.ac.ir/index.php/arya/article/view/257 |
| _version_ | 1818518010928824320 |
|---|---|
| author | Ali Maleki Masoumeh Sadeghi Mahyar Zaman Mohammad Javad Tarrahi Behjat Nabatchi |
| author_facet | Ali Maleki Masoumeh Sadeghi Mahyar Zaman Mohammad Javad Tarrahi Behjat Nabatchi |
| author_sort | Ali Maleki |
| collection | DOAJ |
| description | BACKGROUND: Hypertension (HTN) is one of the most important problems in all parts of the world. Although the disease is usually asymptomatic, its diagnosis and treatment are easy. The aim of this study was to compare the effect of Nifedipine (Adalat®), Captopril and sublingual Nitroglycerin on reducing blood pressure (BP).
METHODS: This study was a parallel group randomized controlled trial. From the patients referred to our heart clinic, 120 patients with severe HTN were enrolled in the study. The patients were randomly allocated into 3 groups A, B, and C. The patients were advised to use 5 drops of Adalat in group A, Captopril 25 mg sublingually in group B, and 1 sublingual Nitroglycerin pearl in group C. The BP was measured every 20 minutes during one hour.
RESULTS: Systolic BP was reduced significantly by Adalat and Captopril compared with sublingual Nitroglycerin in the 20th, 40th and 60th minutes (P = 0.001), but there was no significant difference between Adalat and captopril in reducing systolic BP. In addition, the result of reducing diastolic BP was not significantly different among the three groups.
CONCLUSION: We saw the same effect on reducing BP by Captopril, Adalat, and sublingual Nitroglycerin. Among these three drugs, the side effects of Captopril were the least frequent. Adalat caused headache and flushing. Thus, it seems Captopril can be used instead of Adalat in medical centers.
Keywords: Adalat, Captopril, Nitroglycerin, Severe Hypertension |
| first_indexed | 2024-12-11T01:04:13Z |
| format | Article |
| id | doaj.art-ef0fb5408b8a4c63a0e243f79dd1b936 |
| institution | Directory Open Access Journal |
| issn | 1735-3955 2251-6638 |
| language | English |
| last_indexed | 2024-12-11T01:04:13Z |
| publishDate | 2011-08-01 |
| publisher | Vesnu Publications |
| record_format | Article |
| series | ARYA Atherosclerosis |
| spelling | doaj.art-ef0fb5408b8a4c63a0e243f79dd1b9362022-12-22T01:26:14ZengVesnu PublicationsARYA Atherosclerosis1735-39552251-66382011-08-0172102105241Nifedipine, captopril or sublingual nitroglycerin, which can reduce blood pressure the most?Ali Maleki0Masoumeh Sadeghi1Mahyar Zaman2Mohammad Javad Tarrahi3Behjat Nabatchi4Assistant Professor, Department of Cardiology, Imam Khomeini Hospital of Lorestan University of Medical Sciences, LorestanAssociate Professor, Department of Cardiology, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Center, School of Medicine, Isfahan University of Medical Sciences, IsfahanGeneral Practitioner, Imam Khomeini Hospital of Lorestan University of Medical Sciences, LorestanLecture, Department of Statistics, School of Health, Lorestan University of Medical Sciences, LorestanBSc in Nursing, Imam Khomeini Hospital of Lorestan University of Medical Sciences, LorestanBACKGROUND: Hypertension (HTN) is one of the most important problems in all parts of the world. Although the disease is usually asymptomatic, its diagnosis and treatment are easy. The aim of this study was to compare the effect of Nifedipine (Adalat®), Captopril and sublingual Nitroglycerin on reducing blood pressure (BP). METHODS: This study was a parallel group randomized controlled trial. From the patients referred to our heart clinic, 120 patients with severe HTN were enrolled in the study. The patients were randomly allocated into 3 groups A, B, and C. The patients were advised to use 5 drops of Adalat in group A, Captopril 25 mg sublingually in group B, and 1 sublingual Nitroglycerin pearl in group C. The BP was measured every 20 minutes during one hour. RESULTS: Systolic BP was reduced significantly by Adalat and Captopril compared with sublingual Nitroglycerin in the 20th, 40th and 60th minutes (P = 0.001), but there was no significant difference between Adalat and captopril in reducing systolic BP. In addition, the result of reducing diastolic BP was not significantly different among the three groups. CONCLUSION: We saw the same effect on reducing BP by Captopril, Adalat, and sublingual Nitroglycerin. Among these three drugs, the side effects of Captopril were the least frequent. Adalat caused headache and flushing. Thus, it seems Captopril can be used instead of Adalat in medical centers. Keywords: Adalat, Captopril, Nitroglycerin, Severe Hypertensionhttp://arya.mui.ac.ir/index.php/arya/article/view/257 |
| spellingShingle | Ali Maleki Masoumeh Sadeghi Mahyar Zaman Mohammad Javad Tarrahi Behjat Nabatchi Nifedipine, captopril or sublingual nitroglycerin, which can reduce blood pressure the most? ARYA Atherosclerosis |
| title | Nifedipine, captopril or sublingual nitroglycerin, which can reduce blood pressure the most? |
| title_full | Nifedipine, captopril or sublingual nitroglycerin, which can reduce blood pressure the most? |
| title_fullStr | Nifedipine, captopril or sublingual nitroglycerin, which can reduce blood pressure the most? |
| title_full_unstemmed | Nifedipine, captopril or sublingual nitroglycerin, which can reduce blood pressure the most? |
| title_short | Nifedipine, captopril or sublingual nitroglycerin, which can reduce blood pressure the most? |
| title_sort | nifedipine captopril or sublingual nitroglycerin which can reduce blood pressure the most |
| url | http://arya.mui.ac.ir/index.php/arya/article/view/257 |
| work_keys_str_mv | AT alimaleki nifedipinecaptoprilorsublingualnitroglycerinwhichcanreducebloodpressurethemost AT masoumehsadeghi nifedipinecaptoprilorsublingualnitroglycerinwhichcanreducebloodpressurethemost AT mahyarzaman nifedipinecaptoprilorsublingualnitroglycerinwhichcanreducebloodpressurethemost AT mohammadjavadtarrahi nifedipinecaptoprilorsublingualnitroglycerinwhichcanreducebloodpressurethemost AT behjatnabatchi nifedipinecaptoprilorsublingualnitroglycerinwhichcanreducebloodpressurethemost |