In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs
We assessed concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables using a cross-over design in intact beagle dogs (n = 4). Elevation of inhaled halothane from 1.0% to 2.0% or isoflurane from 1.5% to 2.5% decreased the mean blood p...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-03-01
|
| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861320301298 |
| _version_ | 1818415153250566144 |
|---|---|
| author | Hiroyuki Saito Ryuichi Kambayashi Ai Goto Mihoko Hagiwara-Nagasawa Kiyotaka Hoshiai Yoshio Nunoi Hiroko Izumi-Nakaseko Yasuki Akie Yoshinori Takei Akio Matsumoto Atsushi Sugiyama |
| author_facet | Hiroyuki Saito Ryuichi Kambayashi Ai Goto Mihoko Hagiwara-Nagasawa Kiyotaka Hoshiai Yoshio Nunoi Hiroko Izumi-Nakaseko Yasuki Akie Yoshinori Takei Akio Matsumoto Atsushi Sugiyama |
| author_sort | Hiroyuki Saito |
| collection | DOAJ |
| description | We assessed concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables using a cross-over design in intact beagle dogs (n = 4). Elevation of inhaled halothane from 1.0% to 2.0% or isoflurane from 1.5% to 2.5% decreased the mean blood pressure and prolonged the QRS width without significantly altering the heart rate, PR interval or QT interval. However, the observed changes disappeared after regressions of both anesthetic conditions to their initial settings. These results indicate that hypotension-induced, reflex-mediated increase of sympathetic tone may have counterbalanced the direct negative chronotropic, dromotropic and repolarization slowing effects of the anesthetics. |
| first_indexed | 2024-12-14T11:30:28Z |
| format | Article |
| id | doaj.art-ef116513f3774b34b0e2f2b49449f29f |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-14T11:30:28Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-ef116513f3774b34b0e2f2b49449f29f2022-12-21T23:03:18ZengElsevierJournal of Pharmacological Sciences1347-86132021-03-011453268272In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogsHiroyuki Saito0Ryuichi Kambayashi1Ai Goto2Mihoko Hagiwara-Nagasawa3Kiyotaka Hoshiai4Yoshio Nunoi5Hiroko Izumi-Nakaseko6Yasuki Akie7Yoshinori Takei8Akio Matsumoto9Atsushi Sugiyama10Bioresearch Center, CMIC Pharma Science Co., Ltd 10221, Kobuchisawa, Hokuto, Yamanashi 408-0044, Japan; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, JapanDepartment of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, JapanDepartment of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, JapanDepartment of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, JapanBioresearch Center, CMIC Pharma Science Co., Ltd 10221, Kobuchisawa, Hokuto, Yamanashi 408-0044, Japan; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, JapanDepartment of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, JapanDepartment of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, JapanBioresearch Center, CMIC Pharma Science Co., Ltd 10221, Kobuchisawa, Hokuto, Yamanashi 408-0044, Japan; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, JapanDepartment of Translational Research & Cellular Therapeutics, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, JapanDepartment of Aging Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, JapanDepartment of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan; Department of Translational Research & Cellular Therapeutics, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan; Department of Aging Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan; Corresponding author. Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan. Fax: +81 3 5493 5413.We assessed concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables using a cross-over design in intact beagle dogs (n = 4). Elevation of inhaled halothane from 1.0% to 2.0% or isoflurane from 1.5% to 2.5% decreased the mean blood pressure and prolonged the QRS width without significantly altering the heart rate, PR interval or QT interval. However, the observed changes disappeared after regressions of both anesthetic conditions to their initial settings. These results indicate that hypotension-induced, reflex-mediated increase of sympathetic tone may have counterbalanced the direct negative chronotropic, dromotropic and repolarization slowing effects of the anesthetics.http://www.sciencedirect.com/science/article/pii/S1347861320301298ElectrocardiogramHalothaneIsoflurane |
| spellingShingle | Hiroyuki Saito Ryuichi Kambayashi Ai Goto Mihoko Hagiwara-Nagasawa Kiyotaka Hoshiai Yoshio Nunoi Hiroko Izumi-Nakaseko Yasuki Akie Yoshinori Takei Akio Matsumoto Atsushi Sugiyama In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs Journal of Pharmacological Sciences Electrocardiogram Halothane Isoflurane |
| title | In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs |
| title_full | In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs |
| title_fullStr | In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs |
| title_full_unstemmed | In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs |
| title_short | In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs |
| title_sort | in vivo analysis of concentration dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs |
| topic | Electrocardiogram Halothane Isoflurane |
| url | http://www.sciencedirect.com/science/article/pii/S1347861320301298 |
| work_keys_str_mv | AT hiroyukisaito invivoanalysisofconcentrationdependenteffectsofhalothaneorisofluraneinhalationontheelectrocardiographicandhemodynamicvariablesindogs AT ryuichikambayashi invivoanalysisofconcentrationdependenteffectsofhalothaneorisofluraneinhalationontheelectrocardiographicandhemodynamicvariablesindogs AT aigoto invivoanalysisofconcentrationdependenteffectsofhalothaneorisofluraneinhalationontheelectrocardiographicandhemodynamicvariablesindogs AT mihokohagiwaranagasawa invivoanalysisofconcentrationdependenteffectsofhalothaneorisofluraneinhalationontheelectrocardiographicandhemodynamicvariablesindogs AT kiyotakahoshiai invivoanalysisofconcentrationdependenteffectsofhalothaneorisofluraneinhalationontheelectrocardiographicandhemodynamicvariablesindogs AT yoshionunoi invivoanalysisofconcentrationdependenteffectsofhalothaneorisofluraneinhalationontheelectrocardiographicandhemodynamicvariablesindogs AT hirokoizuminakaseko invivoanalysisofconcentrationdependenteffectsofhalothaneorisofluraneinhalationontheelectrocardiographicandhemodynamicvariablesindogs AT yasukiakie invivoanalysisofconcentrationdependenteffectsofhalothaneorisofluraneinhalationontheelectrocardiographicandhemodynamicvariablesindogs AT yoshinoritakei invivoanalysisofconcentrationdependenteffectsofhalothaneorisofluraneinhalationontheelectrocardiographicandhemodynamicvariablesindogs AT akiomatsumoto invivoanalysisofconcentrationdependenteffectsofhalothaneorisofluraneinhalationontheelectrocardiographicandhemodynamicvariablesindogs AT atsushisugiyama invivoanalysisofconcentrationdependenteffectsofhalothaneorisofluraneinhalationontheelectrocardiographicandhemodynamicvariablesindogs |