Integrons in the Intestinal Microbiota as Reservoirs for Transmission of Antibiotic Resistance Genes
The human intestinal microbiota plays a major beneficial role in immune development and resistance to pathogens. The use of antibiotics, however, can cause the spread of antibiotic resistance genes within the resident intestinal microbiota. Important vectors for this are integrons. This review there...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-03-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-0817/3/2/238 |
| _version_ | 1828349052683550720 |
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| author | Anuradha Ravi Ekaterina Avershina Jane Ludvigsen Trine M. L'Abée-Lund Knut Rudi |
| author_facet | Anuradha Ravi Ekaterina Avershina Jane Ludvigsen Trine M. L'Abée-Lund Knut Rudi |
| author_sort | Anuradha Ravi |
| collection | DOAJ |
| description | The human intestinal microbiota plays a major beneficial role in immune development and resistance to pathogens. The use of antibiotics, however, can cause the spread of antibiotic resistance genes within the resident intestinal microbiota. Important vectors for this are integrons. This review therefore focuses on the integrons in non-pathogenic bacteria as a potential source for the development and persistence of multidrug resistance. Integrons are a group of genetic elements which are assembly platforms that can capture specific gene cassettes and express them. Integrons in pathogenic bacteria have been extensively investigated, while integrons in the intestinal microbiota have not yet gained much attention. Knowledge of the integrons residing in the microbiota, however, can potentially aid in controlling the spread of antibiotic resistance genes to pathogens. |
| first_indexed | 2024-04-14T01:03:49Z |
| format | Article |
| id | doaj.art-ef1432c2192343a9a0c1c6a6176e205e |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-14T01:03:49Z |
| publishDate | 2014-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-ef1432c2192343a9a0c1c6a6176e205e2022-12-22T02:21:18ZengMDPI AGPathogens2076-08172014-03-013223824810.3390/pathogens3020238pathogens3020238Integrons in the Intestinal Microbiota as Reservoirs for Transmission of Antibiotic Resistance GenesAnuradha Ravi0Ekaterina Avershina1Jane Ludvigsen2Trine M. L'Abée-Lund3Knut Rudi4Norwegian University of Life Sciences, Chemistry, Biotechnology and Food science department (IKBM), Campus Ås, Ås 1432, NorwayNorwegian University of Life Sciences, Chemistry, Biotechnology and Food science department (IKBM), Campus Ås, Ås 1432, NorwayNorwegian University of Life Sciences, Chemistry, Biotechnology and Food science department (IKBM), Campus Ås, Ås 1432, NorwayNorwegian University of Life Sciences, Department of Food Safety and Infection Biology, Campus Adamstuen, Oslo 0454, NorwayNorwegian University of Life Sciences, Chemistry, Biotechnology and Food science department (IKBM), Campus Ås, Ås 1432, NorwayThe human intestinal microbiota plays a major beneficial role in immune development and resistance to pathogens. The use of antibiotics, however, can cause the spread of antibiotic resistance genes within the resident intestinal microbiota. Important vectors for this are integrons. This review therefore focuses on the integrons in non-pathogenic bacteria as a potential source for the development and persistence of multidrug resistance. Integrons are a group of genetic elements which are assembly platforms that can capture specific gene cassettes and express them. Integrons in pathogenic bacteria have been extensively investigated, while integrons in the intestinal microbiota have not yet gained much attention. Knowledge of the integrons residing in the microbiota, however, can potentially aid in controlling the spread of antibiotic resistance genes to pathogens.http://www.mdpi.com/2076-0817/3/2/238microbiotaantibiotic resistance genesintegronscommensal flora |
| spellingShingle | Anuradha Ravi Ekaterina Avershina Jane Ludvigsen Trine M. L'Abée-Lund Knut Rudi Integrons in the Intestinal Microbiota as Reservoirs for Transmission of Antibiotic Resistance Genes Pathogens microbiota antibiotic resistance genes integrons commensal flora |
| title | Integrons in the Intestinal Microbiota as Reservoirs for Transmission of Antibiotic Resistance Genes |
| title_full | Integrons in the Intestinal Microbiota as Reservoirs for Transmission of Antibiotic Resistance Genes |
| title_fullStr | Integrons in the Intestinal Microbiota as Reservoirs for Transmission of Antibiotic Resistance Genes |
| title_full_unstemmed | Integrons in the Intestinal Microbiota as Reservoirs for Transmission of Antibiotic Resistance Genes |
| title_short | Integrons in the Intestinal Microbiota as Reservoirs for Transmission of Antibiotic Resistance Genes |
| title_sort | integrons in the intestinal microbiota as reservoirs for transmission of antibiotic resistance genes |
| topic | microbiota antibiotic resistance genes integrons commensal flora |
| url | http://www.mdpi.com/2076-0817/3/2/238 |
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